SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3la8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 TYR A 182
GLY A 227
VAL A 225
ALA A 230
SER A 229
 None
 1.40A 1nbhD-3la8A:
undetectable		 1nbhD-3la8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 8 PHE A 258
LEU A  28
LEU A  70
LEU A 266
 None
 1.00A 2bfpA-3la8A:
undetectable		 2bfpA-3la8A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 8 PHE A 258
LEU A  28
LEU A  70
LEU A 266
 None
 1.01A 2bfpD-3la8A:
undetectable		 2bfpD-3la8A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 6 LEU A  78
LEU A  65
PRO A  22
VAL A  19
 None
 1.18A 2dqyC-3la8A:
undetectable		 2dqyC-3la8A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 LEU A 266
GLY A  25
GLN A 106
ALA A  77
LEU A 103
 None
 1.00A 3dh0B-3la8A:
undetectable		 3dh0B-3la8A:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 6 GLY A 115
TYR A 190
GLY A 208
MET A 209
 None
 0.24A 3e9rA-3la8A:
33.4		 3e9rA-3la8A:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 6 GLY A 115
TYR A 190
GLY A 208
MET A 209
 None
 0.21A 3e9rC-3la8A:
33.5		 3e9rC-3la8A:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		8 / 12 SER A  30
TYR A  85
ALA A 113
GLY A 115
TYR A 190
VAL A 207
GLY A 208
MET A 209
 SO4  A 270 (-4.4A)
None
SO4  A 270 (-3.7A)
None
None
None
None
None
 0.53A 3f8wA-3la8A:
34.1		 3f8wA-3la8A:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		7 / 12 HIS A  83
TYR A  85
GLY A 115
TYR A 190
VAL A 207
GLY A 208
MET A 209
 SO4  A 270 (-3.9A)
None
None
None
None
None
None
 0.32A 3f8wB-3la8A:
34.0		 3f8wB-3la8A:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		7 / 12 SER A  30
TYR A  85
GLY A 115
TYR A 190
VAL A 207
GLY A 208
MET A 209
 SO4  A 270 (-4.4A)
None
None
None
None
None
None
 0.55A 3f8wB-3la8A:
34.0		 3f8wB-3la8A:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		8 / 12 HIS A  83
TYR A  85
ALA A 113
GLY A 115
TYR A 190
VAL A 207
GLY A 208
MET A 209
 SO4  A 270 (-3.9A)
None
SO4  A 270 (-3.7A)
None
None
None
None
None
 0.29A 3f8wC-3la8A:
34.2		 3f8wC-3la8A:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		8 / 12 SER A  30
TYR A  85
ALA A 113
GLY A 115
TYR A 190
VAL A 207
GLY A 208
MET A 209
 SO4  A 270 (-4.4A)
None
SO4  A 270 (-3.7A)
None
None
None
None
None
 0.52A 3f8wC-3la8A:
34.2		 3f8wC-3la8A:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 GLU A  23
ARG A  98
PRO A  22
GLY A 104
LEU A 103
 None
 1.04A 3j6pB-3la8A:
undetectable		 3j6pB-3la8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 8 PRO A 138
HIS A 220
ILE A 216
ARG A  98
 None
 1.11A 3sfeB-3la8A:
undetectable
3sfeC-3la8A:
undetectable		 3sfeB-3la8A:
21.73
3sfeC-3la8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 11 PHE A 258
ALA A 230
ALA A 113
THR A 211
LEU A  26
 None
None
SO4  A 270 (-3.7A)
None
None
 1.01A 4j6cA-3la8A:
undetectable		 4j6cA-3la8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		3 / 3 VAL A 219
GLY A 222
LYS A 224
 None
 0.77A 4k50A-3la8A:
undetectable		 4k50A-3la8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		3 / 3 VAL A 219
GLY A 222
LYS A 224
 None
 0.76A 4k50I-3la8A:
undetectable		 4k50I-3la8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 LEU A  26
LEU A 266
ILE A 265
LEU A 269
LEU A 177
 None
 0.97A 4odoA-3la8A:
undetectable		 4odoA-3la8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 LEU A  26
LEU A 266
ILE A 265
LEU A 269
LEU A 177
 None
 1.01A 4odoB-3la8A:
undetectable		 4odoB-3la8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 LEU A  26
LEU A 266
ILE A 265
LEU A 269
LEU A 177
 None
 1.01A 4odoC-3la8A:
undetectable		 4odoC-3la8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 8 ASN A  52
PRO A  51
PHE A  95
PHE A  13
 None
 1.49A 4v2zC-3la8A:
undetectable		 4v2zC-3la8A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 7 MET A  90
HIS A 130
GLY A 184
ASN A 132
 None
 1.20A 5a5zC-3la8A:
undetectable		 5a5zC-3la8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 12 GLU A  23
ARG A  98
PRO A  22
GLY A 104
LEU A 103
 None
 1.09A 5ogcB-3la8A:
4.0		 5ogcB-3la8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_C_9F2C302_1
(BETA-LACTAMASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 10 ARG A  98
THR A  94
ILE A 216
PRO A 213
TYR A  84
 None
 1.50A 6b68C-3la8A:
0.0
6b68D-3la8A:
0.0		 6b68C-3la8A:
12.54
6b68D-3la8A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_A_9F2A302_1
(BETA-LACTAMASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 9 ARG A  98
THR A  94
ILE A 216
PRO A 213
TYR A  84
 None
 1.49A 6b69A-3la8A:
undetectable
6b69B-3la8A:
undetectable		 6b69A-3la8A:
12.54
6b69B-3la8A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_A_9F2A302_1
(BETA-LACTAMASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 9 ARG A  98
THR A  94
ILE A 216
PRO A 213
TYR A  84
 None
 1.47A 6b6aA-3la8A:
0.0
6b6aB-3la8A:
0.0		 6b6aA-3la8A:
12.54
6b6aB-3la8A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_C_9F2C302_1
(BETA-LACTAMASE)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		5 / 9 ARG A  98
THR A  94
ILE A 216
PRO A 213
TYR A  84
 None
 1.45A 6b6aC-3la8A:
undetectable
6b6aD-3la8A:
undetectable		 6b6aC-3la8A:
12.54
6b6aD-3la8A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE
(Streptococcus
mutans) 		4 / 7 ASN A 137
ALA A 136
LYS A  89
LEU A 139
 None
 1.06A 6ci6A-3la8A:
undetectable		 6ci6A-3la8A:
17.05