SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		5 / 11 ILE A 168
ILE A  66
ILE A 121
PRO A 117
ILE A  77
 None
 1.07A 1dyrA-3lacA:
undetectable		 1dyrA-3lacA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		5 / 9 ILE A  79
GLY A 163
ILE A  65
ILE A 193
ILE A 166
 None
 0.95A 1hshB-3lacA:
undetectable		 1hshB-3lacA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		5 / 12 LEU A  53
ALA A  61
VAL A  42
MET A 161
HIS A 157
 None
 1.34A 1kt4A-3lacA:
undetectable		 1kt4A-3lacA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		5 / 11 LEU A  53
ALA A  61
VAL A  42
MET A 161
HIS A 157
 None
 1.34A 1kt6A-3lacA:
undetectable		 1kt6A-3lacA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		5 / 11 LEU A  53
ALA A  61
VAL A  42
MET A 161
HIS A 157
 None
 1.32A 1kt7A-3lacA:
undetectable		 1kt7A-3lacA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		4 / 6 PRO A  11
GLN A  41
LYS A  25
VAL A  23
 PEG  A 217 (-4.2A)
PEG  A 217 (-2.8A)
None
None
 1.48A 1l2iB-3lacA:
undetectable		 1l2iB-3lacA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		5 / 12 GLY A  72
GLY A  73
GLY A 192
ASP A  76
LEU A 125
 None
 0.95A 4fp9A-3lacA:
undetectable		 4fp9A-3lacA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		5 / 12 GLY A  72
GLY A  73
GLY A 192
ASP A  76
LEU A 125
 None
 0.95A 4fp9C-3lacA:
undetectable		 4fp9C-3lacA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		5 / 12 GLY A  72
GLY A  73
GLY A 192
ASP A  76
LEU A 125
 None
 0.95A 4fp9F-3lacA:
undetectable		 4fp9F-3lacA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		5 / 8 LEU A  53
ALA A  61
VAL A  42
MET A 161
HIS A 157
 None
 1.30A 5nu7A-3lacA:
undetectable		 5nu7A-3lacA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Bacillus
anthracis) 		4 / 7 ILE A 193
VAL A 197
ILE A  37
THR A   3
 None
 0.90A 6cduF-3lacA:
undetectable
6cduG-3lacA:
undetectable		 6cduF-3lacA:
22.56
6cduG-3lacA:
22.56