SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 6 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.22A 1errB-3ladA:
undetectable		 1errB-3ladA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 ALA A 227
LEU A 216
THR A 232
ILE A 238
LEU A 240
 None
 0.95A 1rg7A-3ladA:
undetectable		 1rg7A-3ladA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 239
GLY A 187
ALA A 188
GLY A 196
ILE A 238
 None
 0.80A 1rl8B-3ladA:
undetectable		 1rl8B-3ladA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 5 GLU A  33
ARG A  99
LYS A  94
ASP A  95
 FAD  A 480 (-2.8A)
None
None
None
 1.44A 1rr8C-3ladA:
undetectable		 1rr8C-3ladA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 5 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
None
FAD  A 480 (-4.7A)
FAD  A 480 ( 4.1A)
 1.14A 1vidA-3ladA:
undetectable		 1vidA-3ladA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 6 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
None
FAD  A 480 (-4.7A)
FAD  A 480 ( 4.1A)
 1.17A 2cl5B-3ladA:
undetectable		 2cl5B-3ladA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 ILE A 340
ALA A 337
THR A  29
VAL A   6
VAL A  17
 None
 1.11A 2g78A-3ladA:
undetectable		 2g78A-3ladA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 239
GLY A 187
ALA A 188
GLY A 196
ILE A 238
 None
 0.94A 2nmyB-3ladA:
undetectable		 2nmyB-3ladA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 5 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.29A 2qxsA-3ladA:
undetectable		 2qxsA-3ladA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 5 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.27A 2qxsB-3ladA:
undetectable		 2qxsB-3ladA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		3 / 3 GLU A 455
HIS A 470
GLU A 459
 None
 0.78A 2x45B-3ladA:
undetectable		 2x45B-3ladA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		3 / 3 GLU A 455
HIS A 470
GLU A 459
 None
 0.83A 2x45C-3ladA:
undetectable		 2x45C-3ladA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 6 ARG A 278
ILE A  54
LEU A 101
TYR A  16
 FAD  A 480 (-3.9A)
None
None
None
 1.07A 2ya7D-3ladA:
undetectable		 2ya7D-3ladA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 11 VAL A 206
LEU A 183
GLY A 184
ILE A 186
LYS A 153
 None
 1.34A 3bjwE-3ladA:
undetectable		 3bjwE-3ladA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 239
GLY A 187
ALA A 188
GLY A 196
ILE A 238
 None
 0.77A 3cywA-3ladA:
undetectable		 3cywA-3ladA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 11 GLY A 187
ALA A 188
GLY A 196
LEU A 183
ILE A 238
 None
 0.93A 3em4A-3ladA:
undetectable		 3em4A-3ladA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 239
GLY A 187
ALA A 188
GLY A 196
ILE A 238
 None
 0.88A 3lzsA-3ladA:
undetectable		 3lzsA-3ladA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 239
GLY A 187
ALA A 188
GLY A 196
ILE A 238
 None
 0.95A 3lzsB-3ladA:
undetectable		 3lzsB-3ladA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 9 LEU A 239
GLY A 187
ALA A 188
GLY A 196
ILE A 238
 None
 0.94A 3nujB-3ladA:
undetectable		 3nujB-3ladA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 7 ALA A 315
VAL A 310
VAL A 313
LEU A 148
 None
 0.73A 3o14A-3ladA:
undetectable		 3o14A-3ladA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 ILE A   7
ALA A  19
LEU A 116
ILE A   9
THR A  29
 None
None
None
FAD  A 480 ( 4.9A)
None
 1.23A 3ql3A-3ladA:
undetectable		 3ql3A-3ladA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 5 ALA A 242
GLU A 262
GLU A 264
ALA A 261
 None
 1.35A 3r9tC-3ladA:
undetectable		 3r9tC-3ladA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 ILE A 186
GLY A 184
THR A 247
VAL A 249
ILE A 167
 None
 1.01A 3tkgC-3ladA:
undetectable		 3tkgC-3ladA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 8 ALA A 337
LYS A  21
SER A  22
GLU A 338
 None
 0.85A 3u9hA-3ladA:
undetectable		 3u9hA-3ladA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 8 ALA A 337
LYS A  21
SER A  22
GLU A 338
 None
 0.78A 3u9hB-3ladA:
undetectable		 3u9hB-3ladA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		3 / 3 SER A 152
ASP A 169
ASP A 175
 None
 0.87A 3uj7A-3ladA:
2.5		 3uj7A-3ladA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 8 ALA A 337
LYS A  21
SER A  22
GLU A 338
 None
 0.79A 4bjcA-3ladA:
undetectable		 4bjcA-3ladA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		3 / 3 TYR A 314
HIS A 343
ARG A 339
 None
 0.93A 4htfA-3ladA:
2.8		 4htfA-3ladA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 SER A  56
GLY A 172
ASP A 175
GLY A  52
LYS A  94
 FAD  A 480 (-3.3A)
None
None
FAD  A 480 (-3.3A)
None
 1.30A 4pevB-3ladA:
undetectable		 4pevB-3ladA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 GLY A  12
ALA A  11
ILE A 109
ILE A  20
VAL A 114
 FAD  A 480 (-3.1A)
None
None
None
None
 0.90A 4xdrA-3ladA:
undetectable		 4xdrA-3ladA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 7 LEU A 174
PRO A  55
LEU A 195
GLU A 194
 None
 0.98A 4z4fA-3ladA:
undetectable		 4z4fA-3ladA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		3 / 3 LYS A  65
ARG A 201
HIS A  67
 None
 1.26A 4zbrA-3ladA:
2.8		 4zbrA-3ladA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 5 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
None
FAD  A 480 (-4.7A)
FAD  A 480 ( 4.1A)
 1.17A 5fhrA-3ladA:
undetectable		 5fhrA-3ladA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 GLY A 184
LEU A 183
VAL A  51
GLY A 196
LEU A 209
 None
 1.07A 5hg0A-3ladA:
undetectable		 5hg0A-3ladA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 GLY A 184
LEU A 183
VAL A  51
GLY A 196
LEU A 209
 None
 1.05A 5hg0B-3ladA:
undetectable		 5hg0B-3ladA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 10 ALA A  18
GLU A 332
ALA A  11
GLY A  12
ALA A 149
 None
None
None
FAD  A 480 (-3.1A)
FAD  A 480 (-4.6A)
 1.19A 5lf3H-3ladA:
undetectable
5lf3I-3ladA:
undetectable		 5lf3H-3ladA:
19.79
5lf3I-3ladA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 10 ALA A  18
GLU A 332
ALA A  11
GLY A  12
ALA A 149
 None
None
None
FAD  A 480 (-3.1A)
FAD  A 480 (-4.6A)
 1.20A 5lf3V-3ladA:
2.3
5lf3W-3ladA:
undetectable		 5lf3V-3ladA:
19.79
5lf3W-3ladA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 10 LEU A 148
ILE A   9
GLY A  10
GLY A  15
VAL A   6
 None
FAD  A 480 ( 4.9A)
FAD  A 480 (-3.2A)
None
None
 0.99A 5o96C-3ladA:
undetectable
5o96D-3ladA:
undetectable		 5o96C-3ladA:
20.08
5o96D-3ladA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 7 LEU A 174
PRO A  55
LEU A 195
GLU A 194
 None
 1.02A 5t7bA-3ladA:
undetectable		 5t7bA-3ladA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 ALA A 468
GLY A 430
ALA A 433
VAL A 404
THR A 438
 None
 0.94A 5w4zA-3ladA:
undetectable		 5w4zA-3ladA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 ALA A 468
GLY A 430
ALA A 433
VAL A 404
THR A 438
 None
 0.95A 5w4zB-3ladA:
undetectable		 5w4zB-3ladA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 6 GLY A 203
SER A  63
VAL A 179
TRP A 199
 None
 1.00A 5ysiA-3ladA:
undetectable		 5ysiA-3ladA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		4 / 5 VAL A   6
THR A  29
VAL A 319
LEU A 285
 None
None
None
FAD  A 480 (-4.8A)
 1.01A 6bqgA-3ladA:
2.6		 6bqgA-3ladA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 239
GLY A 187
ALA A 188
GLY A 196
ILE A 238
 None
 0.87A 6dh6B-3ladA:
undetectable		 6dh6B-3ladA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3lad DIHYDROLIPOAMIDE
DEHYDROGENASE
(Azotobacter
vinelandii) 		5 / 11 VAL A   6
THR A  29
VAL A 310
ALA A  19
VAL A 129
 None
 1.35A 6dryA-3ladA:
2.3		 6dryA-3ladA:
23.40