SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3lae UPF0053 PROTEIN
HI0107
(Haemophilus
influenzae) 		5 / 12 ILE A  55
LEU A  16
VAL A  75
ALA A  73
ILE A  10
 None
 1.04A 1epbA-3laeA:
undetectable		 1epbA-3laeA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3lae UPF0053 PROTEIN
HI0107
(Haemophilus
influenzae) 		5 / 9 ILE A  46
ILE A  62
ASP A  48
GLU A  49
THR A  51
 None
 1.27A 2dtjA-3laeA:
undetectable
2dtjB-3laeA:
undetectable		 2dtjA-3laeA:
17.95
2dtjB-3laeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3lae UPF0053 PROTEIN
HI0107
(Haemophilus
influenzae) 		5 / 9 ILE A  46
ILE A  62
ASP A  48
GLY A  66
THR A  51
 None
None
None
EDO  A  81 (-3.7A)
None
 1.03A 2dtjA-3laeA:
undetectable
2dtjB-3laeA:
undetectable		 2dtjA-3laeA:
17.95
2dtjB-3laeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3lae UPF0053 PROTEIN
HI0107
(Haemophilus
influenzae) 		4 / 8 ASN A  20
ARG A  17
ASP A  56
ILE A  55
 None
PO4  A  79 (-4.0A)
None
None
 0.94A 4k0bA-3laeA:
undetectable		 4k0bA-3laeA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3lae UPF0053 PROTEIN
HI0107
(Haemophilus
influenzae) 		4 / 8 ASN A  20
ARG A  17
ASP A  56
ILE A  55
 None
PO4  A  79 (-4.0A)
None
None
 0.96A 4l7iA-3laeA:
undetectable		 4l7iA-3laeA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3lae UPF0053 PROTEIN
HI0107
(Haemophilus
influenzae) 		5 / 12 ILE A  62
LEU A  58
GLY A  12
ILE A  46
LEU A  40
 None
None
EDO  A  80 ( 4.8A)
None
None
 1.05A 6dwnC-3laeA:
undetectable		 6dwnC-3laeA:
17.86