SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		5 / 12 PHE A 141
GLY A 143
SER A 148
LEU A 117
LEU A  95
 HEM  A 200 ( 4.9A)
None
HEM  A 200 ( 4.1A)
IMD  A 502 (-4.2A)
None
 1.29A 1fm6X-3lahA:
undetectable		 1fm6X-3lahA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		5 / 12 THR A  12
GLY A 147
GLY A 143
PHE A 152
ASN A  74
 None
None
None
None
IMD  A 501 ( 4.6A)
 1.06A 1nv8A-3lahA:
2.5		 1nv8A-3lahA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 8 LEU A  26
GLU A  32
THR A  38
ILE A  10
 None
 1.06A 1qvtA-3lahA:
undetectable		 1qvtA-3lahA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		3 / 3 ASP A  45
ARG A 135
ASP A  42
 None
HEM  A 200 (-3.6A)
None
 0.66A 1vptA-3lahA:
undetectable		 1vptA-3lahA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		5 / 11 LEU A 172
ARG A 163
ARG A 171
GLY A 168
LYS A 166
 None
 1.10A 2bxmA-3lahA:
undetectable		 2bxmA-3lahA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 5 SER A 148
MET A  98
PHE A  94
ILE A  75
 HEM  A 200 ( 4.1A)
HEM  A 200 ( 3.5A)
HEM  A 200 (-4.7A)
None
 1.45A 3g59A-3lahA:
0.0		 3g59A-3lahA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 8 TYR A  17
ILE A  51
VAL A  70
ILE A  10
 None
 0.78A 3p4wC-3lahA:
undetectable		 3p4wC-3lahA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		3 / 3 ASP A  45
ARG A 135
ASP A  42
 None
HEM  A 200 (-3.6A)
None
 0.69A 4fzvA-3lahA:
undetectable		 4fzvA-3lahA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		5 / 10 TYR A 140
VAL A  48
ILE A  51
LEU A  16
LEU A  13
 IMD  A 501 (-4.4A)
None
None
None
None
 1.44A 4jq4B-3lahA:
undetectable		 4jq4B-3lahA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 5 PHE A 178
PRO A 181
VAL A 182
ALA A 126
 None
 0.85A 4w5oA-3lahA:
undetectable		 4w5oA-3lahA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 5 PHE A 178
PRO A 181
VAL A 182
ALA A 126
 None
 0.90A 4z4cA-3lahA:
undetectable		 4z4cA-3lahA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 5 PHE A 178
PRO A 181
VAL A 182
ALA A 126
 None
 0.88A 4z4dA-3lahA:
undetectable		 4z4dA-3lahA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 5 PHE A 178
PRO A 181
VAL A 182
ALA A 126
 None
 0.86A 4z4eA-3lahA:
undetectable		 4z4eA-3lahA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 6 PHE A 178
PRO A 181
VAL A 182
ALA A 126
 None
 0.85A 5t7bA-3lahA:
undetectable		 5t7bA-3lahA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		3 / 3 ASP A  45
ARG A 135
ASP A  42
 None
HEM  A 200 (-3.6A)
None
 0.84A 5zvgA-3lahA:
undetectable		 5zvgA-3lahA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		3 / 3 ASP A  45
ARG A 135
ASP A  42
 None
HEM  A 200 (-3.6A)
None
 0.82A 5zvgB-3lahA:
undetectable		 5zvgB-3lahA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Caldanaerobacter
subterraneus) 		3 / 3 ARG A  68
PHE A 141
GLY A 143
 None
HEM  A 200 ( 4.9A)
None
 0.80A 6fgdA-3lahA:
undetectable		 6fgdA-3lahA:
19.56