SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  86
PHE A  84
PHE A  66
LEU A  24
VAL A  11
 None
 1.47A 1q23D-3laoA:
undetectable
1q23E-3laoA:
undetectable		 1q23D-3laoA:
21.19
1q23E-3laoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 11 TYR A  86
PHE A  84
PHE A  66
LEU A  24
VAL A  11
 None
 1.48A 1q23G-3laoA:
undetectable		 1q23G-3laoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  24
VAL A 107
GLY A 117
ALA A 116
LEU A  38
 None
None
None
GOL  A 262 (-2.8A)
None
 0.97A 1r9oA-3laoA:
undetectable		 1r9oA-3laoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  38
TRP A  94
ALA A 116
GLY A  69
 None
None
GOL  A 262 (-2.8A)
None
 0.85A 2wq5A-3laoA:
undetectable		 2wq5A-3laoA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A  33
PHE A  66
ALA A  61
LEU A  41
 None
 0.99A 3t3zA-3laoA:
undetectable		 3t3zA-3laoA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A  33
PHE A  66
ALA A  61
LEU A  41
 None
 0.98A 3t3zB-3laoA:
undetectable		 3t3zB-3laoA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 5 PHE A  33
PHE A  66
ALA A  61
LEU A  41
 None
 1.00A 3t3zC-3laoA:
undetectable		 3t3zC-3laoA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 167
PHE A  33
LEU A  59
LEU A  24
LEU A 122
 None
 1.35A 4j03A-3laoA:
undetectable		 4j03A-3laoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  68
ASP A  34
PHE A  66
LEU A  41
LEU A  59
 None
 0.81A 4m2xA-3laoA:
undetectable		 4m2xA-3laoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 180
TYR A 166
GLU A 177
 None
 0.35A 4zzbE-3laoA:
undetectable		 4zzbE-3laoA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 137
ILE A 167
PHE A 173
ALA A 163
 None
 0.98A 5msdA-3laoA:
undetectable		 5msdA-3laoA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		3 / 3 THR A  67
PRO A  93
ARG A 101
 None
 0.77A 5nd7B-3laoA:
undetectable		 5nd7B-3laoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 10 PHE A  33
GLY A   9
ALA A  39
LEU A  38
PHE A 220
 None
 1.42A 5zjiA-3laoA:
undetectable
5zjiJ-3laoA:
undetectable		 5zjiA-3laoA:
17.14
5zjiJ-3laoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3lao ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 154
ILE A 118
LEU A 122
ALA A 178
LEU A 184
 None
 1.38A 5zwrB-3laoA:
undetectable		 5zwrB-3laoA:
23.19