SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3laq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3laq UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Mus
musculus) 		4 / 4 ILE U 211
MET U 217
VAL U 127
GLY U 238
 None
 1.21A 1e06B-3laqU:
undetectable		 1e06B-3laqU:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 3laq UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		5 / 10 TRP A  75
GLY A  98
ALA A  63
TYR A  59
TYR A 102
 None
 1.42A 1jglH-3laqA:
undetectable
1jglL-3laqA:
undetectable		 1jglH-3laqA:
21.11
1jglL-3laqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3laq UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Mus
musculus;
Mus
musculus) 		5 / 11 GLU U 125
LEU U 180
LEU U 129
TYR A  25
THR U 154
 None
 1.17A 1jomA-3laqU:
undetectable		 1jomA-3laqU:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3laq UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Mus
musculus) 		3 / 3 TYR U 141
ARG U 214
GLN U 183
 None
 0.89A 1tw4A-3laqU:
undetectable		 1tw4A-3laqU:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3laq UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Mus
musculus) 		4 / 6 TYR A  85
TRP A 113
TYR A 115
GLN A 125
 None
 1.12A 2pgzD-3laqA:
undetectable
2pgzE-3laqA:
undetectable		 2pgzD-3laqA:
15.45
2pgzE-3laqA:
15.45