SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3las'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		5 / 8 CYH A  38
ASP A  40
HIS A  91
CYH A  94
GLY A  95
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 (-2.3A)
ZN  A 167 ( 4.8A)
 0.37A 1ekjA-3lasA:
14.0
1ekjB-3lasA:
14.2		 1ekjA-3lasA:
24.32
1ekjB-3lasA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		5 / 8 CYH A  38
ASP A  40
HIS A  91
CYH A  94
GLY A  95
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 (-2.3A)
ZN  A 167 ( 4.8A)
 0.80A 1ekjA-3lasA:
14.0
1ekjB-3lasA:
14.2		 1ekjA-3lasA:
24.32
1ekjB-3lasA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		5 / 8 CYH A  38
ASP A  40
HIS A  91
CYH A  94
GLY A  95
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 (-2.3A)
ZN  A 167 ( 4.8A)
 0.39A 1ekjA-3lasA:
14.0
1ekjB-3lasA:
14.2		 1ekjA-3lasA:
24.32
1ekjB-3lasA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		4 / 7 CYH A  38
ASP A  40
HIS A  91
GLY A  95
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 ( 4.8A)
 0.36A 1ekjE-3lasA:
13.0
1ekjF-3lasA:
7.5		 1ekjE-3lasA:
24.32
1ekjF-3lasA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		4 / 7 CYH A  38
ASP A  40
HIS A  91
GLY A  95
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 ( 4.8A)
 0.77A 1ekjE-3lasA:
13.0
1ekjF-3lasA:
7.5		 1ekjE-3lasA:
24.32
1ekjF-3lasA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		5 / 8 CYH A  38
ASP A  40
HIS A  91
CYH A  94
GLY A  95
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 (-2.3A)
ZN  A 167 ( 4.8A)
 0.39A 1ekjG-3lasA:
14.4
1ekjH-3lasA:
9.4		 1ekjG-3lasA:
24.32
1ekjH-3lasA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		5 / 8 CYH A  38
ASP A  40
HIS A  91
CYH A  94
GLY A  95
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 (-2.3A)
ZN  A 167 ( 4.8A)
 0.79A 1ekjG-3lasA:
14.4
1ekjH-3lasA:
9.4		 1ekjG-3lasA:
24.32
1ekjH-3lasA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		4 / 6 CYH A  38
ASP A  40
HIS A  91
CYH A  94
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 (-2.3A)
 0.28A 1ekjG-3lasA:
14.4
1ekjH-3lasA:
10.1		 1ekjG-3lasA:
24.32
1ekjH-3lasA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		4 / 7 PHE A 124
ARG A  65
HIS A  90
VAL A 165
 None
 1.29A 1wu8A-3lasA:
undetectable
1wu8C-3lasA:
undetectable		 1wu8A-3lasA:
23.74
1wu8C-3lasA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		4 / 7 VAL A 131
SER A 130
LEU A  89
HIS A  91
 None
None
None
ZN  A 167 (-3.2A)
 0.94A 2f78A-3lasA:
undetectable		 2f78A-3lasA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		4 / 7 VAL A 131
SER A 130
LEU A  89
HIS A  91
 None
None
None
ZN  A 167 (-3.2A)
 0.89A 2f78B-3lasA:
undetectable		 2f78B-3lasA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		4 / 6 VAL A 131
SER A 130
LEU A  89
HIS A  91
 None
None
None
ZN  A 167 (-3.2A)
 0.95A 2f8dA-3lasA:
undetectable		 2f8dA-3lasA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		5 / 12 GLY A 152
ALA A 153
LEU A 137
LEU A 138
LEU A 122
 None
 0.84A 2nyuA-3lasA:
4.1		 2nyuA-3lasA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		6 / 10 CYH A  38
ASP A  40
HIS A  91
CYH A  94
GLY A  95
ALA A  96
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 (-2.3A)
ZN  A 167 ( 4.8A)
None
 0.89A 3ucjA-3lasA:
14.2		 3ucjA-3lasA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		6 / 10 CYH A  38
ASP A  40
HIS A  91
CYH A  94
GLY A  95
ALA A  96
 ZN  A 167 (-2.2A)
None
ZN  A 167 (-3.2A)
ZN  A 167 (-2.3A)
ZN  A 167 ( 4.8A)
None
 0.88A 3ucjB-3lasA:
14.6		 3ucjB-3lasA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3las PUTATIVE CARBONIC
ANHYDRASE
(Streptococcus
mutans) 		5 / 9 VAL A 131
LEU A  74
LEU A  89
LEU A  59
ILE A  35
 None
 1.33A 4ubsA-3lasA:
undetectable		 4ubsA-3lasA:
19.90