SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		5 / 12 ALA A  76
LEU A 140
ALA A 139
VAL A  30
ILE A  31
 None
 0.96A 1fm6U-3lb5A:
undetectable		 1fm6U-3lb5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		4 / 8 VAL A  88
THR A  87
VAL A  77
ILE A  73
 None
 0.96A 2qbmA-3lb5A:
undetectable		 2qbmA-3lb5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		5 / 12 ALA A  76
LEU A 140
ALA A 139
VAL A  30
ILE A  31
 None
 0.93A 3h0aA-3lb5A:
undetectable		 3h0aA-3lb5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		5 / 11 PRO A  41
ASN A 132
VAL A  24
ALA A  32
ILE A  73
 None
 1.40A 3n23A-3lb5A:
undetectable		 3n23A-3lb5A:
10.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		7 / 10 ILE A  10
PHE A  11
ASP A  35
ILE A  36
LEU A  45
HIS A 104
HIS A 106
 UNL  A 141 ( 4.9A)
None
UNL  A 141 ( 4.2A)
UNL  A 141 ( 4.0A)
None
None
None
 0.63A 3o1cA-3lb5A:
14.8		 3o1cA-3lb5A:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		7 / 10 ILE A  10
PHE A  11
ASP A  35
ILE A  36
LEU A  45
HIS A 104
HIS A 106
 UNL  A 141 ( 4.9A)
None
UNL  A 141 ( 4.2A)
UNL  A 141 ( 4.0A)
None
None
None
 0.61A 3o1xA-3lb5A:
14.7		 3o1xA-3lb5A:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		6 / 12 ILE A  73
ALA A  76
LEU A 140
ALA A 139
VAL A  30
ILE A  31
 None
 1.43A 3oapA-3lb5A:
undetectable		 3oapA-3lb5A:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		7 / 10 ILE A  10
PHE A  11
ASP A  35
ILE A  36
LEU A  45
HIS A 104
HIS A 106
 UNL  A 141 ( 4.9A)
None
UNL  A 141 ( 4.2A)
UNL  A 141 ( 4.0A)
None
None
None
 0.64A 3qgzA-3lb5A:
14.8		 3qgzA-3lb5A:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		7 / 12 ILE A  10
PHE A  11
ASP A  35
LEU A  45
VAL A 100
HIS A 104
HIS A 106
 UNL  A 141 ( 4.9A)
None
UNL  A 141 ( 4.2A)
None
None
None
None
 0.47A 5km9B-3lb5A:
14.9		 5km9B-3lb5A:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION
(Bartonella
henselae) 		8 / 12 PHE A  11
ASP A  35
ILE A  36
LEU A  45
THR A  99
VAL A 100
HIS A 104
HIS A 106
 None
UNL  A 141 ( 4.2A)
UNL  A 141 ( 4.0A)
None
None
None
None
None
 0.48A 5uvmB-3lb5A:
15.2		 5uvmB-3lb5A:
32.75