SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 273
LEU A 320
PRO A 264
GLY A 352
ILE A 353
 None
 1.23A 1kglA-3lcaA:
undetectable		 1kglA-3lcaA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 273
PHE A 276
ASN A 379
ILE A 353
LEU A 302
 None
 1.03A 1z11A-3lcaA:
undetectable		 1z11A-3lcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 273
PHE A 276
ASN A 379
ILE A 353
LEU A 302
 None
 0.97A 1z11C-3lcaA:
undetectable		 1z11C-3lcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 273
PHE A 276
ASN A 379
ILE A 353
LEU A 302
 None
 1.03A 1z11D-3lcaA:
undetectable		 1z11D-3lcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 364
THR A 387
PHE A 401
PHE A 276
LEU A 346
 None
 1.17A 2nyrA-3lcaA:
undetectable		 2nyrA-3lcaA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 155
TYR A 126
PHE A 163
ILE A 167
 None
 0.95A 3jz0B-3lcaA:
3.0		 3jz0B-3lcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 355
PHE A 272
PHE A 273
 None
 0.72A 3lk0D-3lcaA:
undetectable		 3lk0D-3lcaA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 368
SER A 371
ALA A 345
LEU A 384
 None
 1.08A 3ravA-3lcaA:
2.2		 3ravA-3lcaA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 368
SER A 371
ALA A 345
LEU A 384
 None
 1.08A 3rd0A-3lcaA:
undetectable		 3rd0A-3lcaA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 273
PHE A 276
ASN A 379
ILE A 353
LEU A 302
 None
 0.99A 3t3rA-3lcaA:
undetectable		 3t3rA-3lcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 273
PHE A 276
PHE A 354
ASN A 379
LEU A 302
 None
 1.35A 3t3sA-3lcaA:
undetectable		 3t3sA-3lcaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 273
PHE A 276
ASN A 379
LEU A 302
 None
 0.93A 4ejgC-3lcaA:
undetectable		 4ejgC-3lcaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 273
PHE A 276
ASN A 379
LEU A 320
 None
 0.82A 4ejgC-3lcaA:
undetectable		 4ejgC-3lcaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 382
TYR A 306
TYR A 350
PHE A 383
 None
 1.12A 4g10A-3lcaA:
undetectable		 4g10A-3lcaA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 438
GLY A 419
GLN A 420
ALA A 453
PHE A 435
 None
None
GOL  A   1 (-3.2A)
None
None
 1.04A 4r29A-3lcaA:
undetectable		 4r29A-3lcaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 438
GLY A 419
GLN A 420
ALA A 453
PHE A 435
 None
None
GOL  A   1 (-3.2A)
None
None
 1.03A 4r29D-3lcaA:
undetectable		 4r29D-3lcaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 342
LEU A 346
LEU A 298
LEU A 302
 None
 0.63A 4wg0B-3lcaA:
undetectable
4wg0C-3lcaA:
undetectable		 4wg0B-3lcaA:
4.32
4wg0C-3lcaA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 298
LEU A 302
GLU A 342
LEU A 346
 None
 0.67A 4wg0L-3lcaA:
undetectable
4wg0M-3lcaA:
undetectable		 4wg0L-3lcaA:
4.32
4wg0M-3lcaA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 382
PHE A 356
LEU A 357
ILE A 353
PHE A 276
 None
 0.89A 5b8iC-3lcaA:
undetectable		 5b8iC-3lcaA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lca PROTEIN TOM71
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 395
ILE A 382
HIS A 417
 None
 0.68A 5z12B-3lcaA:
undetectable		 5z12B-3lcaA:
9.98