SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		5 / 11 LEU A  92
GLY A 142
GLY A  87
ILE A 149
LEU A   4
 None
 1.14A 1p91A-3lcmA:
undetectable		 1p91A-3lcmA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		4 / 4 VAL A  61
ASP A  69
LEU A   4
ARG A  98
 None
 1.36A 2ziaA-3lcmA:
3.0		 2ziaA-3lcmA:
17.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		4 / 5 ARG A  55
TYR A 106
TYR A 108
LEU A 113
 NAP  A 198 ( 4.1A)
NAP  A 198 (-4.2A)
NAP  A 198 (-4.4A)
None
 0.18A 4f8yA-3lcmA:
35.5
4f8yB-3lcmA:
33.2		 4f8yA-3lcmA:
100.00
4f8yB-3lcmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		4 / 6 ARG A  55
TYR A 106
TYR A 108
LEU A 113
 NAP  A 198 ( 4.1A)
NAP  A 198 (-4.2A)
NAP  A 198 (-4.4A)
None
 0.43A 4f8yA-3lcmA:
35.5
4f8yB-3lcmA:
33.2		 4f8yA-3lcmA:
100.00
4f8yB-3lcmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		4 / 7 ARG A  55
TYR A 106
TYR A 108
LEU A 113
 NAP  A 198 ( 4.1A)
NAP  A 198 (-4.2A)
NAP  A 198 (-4.4A)
None
 0.34A 4f8yC-3lcmA:
34.7
4f8yD-3lcmA:
32.9		 4f8yC-3lcmA:
100.00
4f8yD-3lcmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		4 / 5 ARG A  55
TYR A 106
TYR A 108
LEU A 113
 NAP  A 198 ( 4.1A)
NAP  A 198 (-4.2A)
NAP  A 198 (-4.4A)
None
 0.42A 4f8yC-3lcmA:
34.7
4f8yD-3lcmA:
32.9		 4f8yC-3lcmA:
100.00
4f8yD-3lcmA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		4 / 8 ILE A 166
ILE A 125
MET A  88
GLY A  87
 None
 0.83A 4hdlA-3lcmA:
undetectable		 4hdlA-3lcmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		5 / 12 LEU A  27
VAL A  23
ILE A   5
ILE A   3
ALA A  74
 None
 1.00A 4ltwA-3lcmA:
undetectable		 4ltwA-3lcmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		4 / 6 ASP A  97
PRO A 152
TYR A 106
LEU A 113
 None
None
NAP  A 198 (-4.2A)
None
 0.92A 5bmvB-3lcmA:
2.1		 5bmvB-3lcmA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		4 / 7 ILE A  78
ILE A 125
THR A 185
ILE A 184
 None
 0.86A 5murB-3lcmA:
undetectable		 5murB-3lcmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		5 / 10 TYR A  39
TYR A   7
ILE A   5
ILE A   3
ILE A  19
 None
 1.36A 5vkqA-3lcmA:
undetectable
5vkqD-3lcmA:
undetectable		 5vkqA-3lcmA:
7.16
5vkqD-3lcmA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		5 / 10 ILE A  19
TYR A  39
TYR A   7
ILE A   5
ILE A   3
 None
 1.40A 5vkqA-3lcmA:
undetectable
5vkqB-3lcmA:
undetectable		 5vkqA-3lcmA:
7.16
5vkqB-3lcmA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		5 / 9 ILE A  19
TYR A  39
TYR A   7
ILE A   5
ILE A   3
 None
 1.37A 5vkqB-3lcmA:
undetectable
5vkqC-3lcmA:
undetectable		 5vkqB-3lcmA:
7.16
5vkqC-3lcmA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lcm PUTATIVE
OXIDOREDUCTASE
(Streptococcus
mutans) 		5 / 10 ILE A  19
TYR A  39
TYR A   7
ILE A   5
ILE A   3
 None
 1.38A 5vkqC-3lcmA:
undetectable
5vkqD-3lcmA:
undetectable		 5vkqC-3lcmA:
7.16
5vkqD-3lcmA:
7.16