SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lcr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 8 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.89A 1v54C-3lcrA:
undetectable
1v54J-3lcrA:
undetectable		 1v54C-3lcrA:
20.45
1v54J-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 8 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.84A 1v54P-3lcrA:
undetectable
1v54W-3lcrA:
undetectable		 1v54P-3lcrA:
20.45
1v54W-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		5 / 12 PRO A  46
VAL A 141
ILE A  61
VAL A 116
LEU A 145
 None
 1.32A 1z9hA-3lcrA:
undetectable		 1z9hA-3lcrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		5 / 12 PRO A  46
VAL A 141
ILE A  61
VAL A 116
LEU A 145
 None
 1.31A 1z9hB-3lcrA:
undetectable		 1z9hB-3lcrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		5 / 12 PRO A  46
VAL A 141
ILE A  61
VAL A 116
LEU A 145
 None
 1.31A 1z9hC-3lcrA:
undetectable		 1z9hC-3lcrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 8 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.90A 2dyrC-3lcrA:
undetectable
2dyrJ-3lcrA:
undetectable		 2dyrC-3lcrA:
20.45
2dyrJ-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 8 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.88A 2dyrP-3lcrA:
undetectable
2dyrW-3lcrA:
undetectable		 2dyrP-3lcrA:
20.45
2dyrW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
GLN A 227
LEU A 178
PHE A 182
 None
 1.04A 2dysP-3lcrA:
undetectable
2dysW-3lcrA:
undetectable		 2dysP-3lcrA:
20.45
2dysW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
GLN A 227
LEU A 178
PHE A 182
 None
 1.00A 2eijP-3lcrA:
undetectable
2eijW-3lcrA:
undetectable		 2eijP-3lcrA:
20.45
2eijW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.86A 2eikC-3lcrA:
undetectable
2eikJ-3lcrA:
undetectable		 2eikC-3lcrA:
20.45
2eikJ-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 8 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.84A 2eikP-3lcrA:
undetectable
2eikW-3lcrA:
undetectable		 2eikP-3lcrA:
20.45
2eikW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 8 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.86A 2eilC-3lcrA:
undetectable
2eilJ-3lcrA:
undetectable		 2eilC-3lcrA:
20.45
2eilJ-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.96A 2eimP-3lcrA:
undetectable
2eimW-3lcrA:
undetectable		 2eimP-3lcrA:
20.45
2eimW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
GLN A 227
LEU A 178
PHE A 182
 None
 1.03A 2einC-3lcrA:
undetectable
2einJ-3lcrA:
undetectable		 2einC-3lcrA:
20.45
2einJ-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 6 LEU A 229
GLN A 227
LEU A 178
PHE A 182
 None
 0.99A 2einP-3lcrA:
undetectable
2einW-3lcrA:
undetectable		 2einP-3lcrA:
20.45
2einW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 6 LEU A 229
GLN A 227
LEU A 178
PHE A 182
 None
 1.03A 2zxwP-3lcrA:
undetectable
2zxwW-3lcrA:
undetectable		 2zxwP-3lcrA:
20.45
2zxwW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 6 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.88A 3abkP-3lcrA:
undetectable
3abkW-3lcrA:
undetectable		 3abkP-3lcrA:
20.45
3abkW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.90A 3ag2P-3lcrA:
undetectable
3ag2W-3lcrA:
undetectable		 3ag2P-3lcrA:
20.45
3ag2W-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 8 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.88A 3ag4C-3lcrA:
undetectable
3ag4J-3lcrA:
undetectable		 3ag4C-3lcrA:
20.45
3ag4J-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.89A 3ag4P-3lcrA:
undetectable
3ag4W-3lcrA:
undetectable		 3ag4P-3lcrA:
20.45
3ag4W-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.93A 3asnC-3lcrA:
undetectable
3asnJ-3lcrA:
undetectable		 3asnC-3lcrA:
20.45
3asnJ-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.87A 3asnP-3lcrA:
undetectable
3asnW-3lcrA:
undetectable		 3asnP-3lcrA:
20.45
3asnW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.86A 3asoP-3lcrA:
undetectable
3asoW-3lcrA:
undetectable		 3asoP-3lcrA:
20.45
3asoW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		5 / 12 ILE A 158
ALA A 129
LEU A 275
LEU A  82
VAL A 223
 None
 1.15A 3ix9A-3lcrA:
undetectable		 3ix9A-3lcrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		5 / 12 ILE A 158
ALA A 129
LEU A 275
LEU A  82
VAL A 223
 None
 1.13A 3ix9B-3lcrA:
undetectable		 3ix9B-3lcrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 6 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.81A 3wg7C-3lcrA:
undetectable
3wg7J-3lcrA:
undetectable		 3wg7C-3lcrA:
20.45
3wg7J-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 6 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.87A 3wg7P-3lcrA:
undetectable
3wg7W-3lcrA:
undetectable		 3wg7P-3lcrA:
20.45
3wg7W-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.84A 3x2qC-3lcrA:
undetectable
3x2qJ-3lcrA:
undetectable		 3x2qC-3lcrA:
20.45
3x2qJ-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.86A 3x2qP-3lcrA:
undetectable
3x2qW-3lcrA:
undetectable		 3x2qP-3lcrA:
20.45
3x2qW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		3 / 3 PRO A  65
TYR A  75
GLY A  71
 None
 0.56A 4g2zA-3lcrA:
undetectable		 4g2zA-3lcrA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		3 / 3 LEU A  32
ARG A  33
MET A  68
 None
 0.98A 4m11C-3lcrA:
undetectable		 4m11C-3lcrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 6 LEU A  11
ASN A 179
LEU A  19
GLU A  18
 None
 1.13A 4nc3A-3lcrA:
undetectable		 4nc3A-3lcrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		5 / 12 ARG A 224
SER A 132
GLY A 135
ALA A 243
TYR A 222
 None
FMT  A3613 (-3.0A)
None
None
None
 1.18A 4r29C-3lcrA:
undetectable		 4r29C-3lcrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 8 PHE A   6
SER A 195
ALA A  22
LEU A  25
 None
 1.03A 4rkuA-3lcrA:
undetectable
4rkuJ-3lcrA:
undetectable		 4rkuA-3lcrA:
18.18
4rkuJ-3lcrA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		5 / 7 LEU A 229
GLN A 227
PHE A 174
LEU A 178
PHE A 182
 None
 1.38A 5b1aC-3lcrA:
undetectable
5b1aJ-3lcrA:
undetectable		 5b1aC-3lcrA:
20.45
5b1aJ-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.84A 5b1aP-3lcrA:
undetectable
5b1aW-3lcrA:
undetectable		 5b1aP-3lcrA:
20.45
5b1aW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.91A 5b1bP-3lcrA:
undetectable
5b1bW-3lcrA:
undetectable		 5b1bP-3lcrA:
20.45
5b1bW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.89A 5b3sC-3lcrA:
undetectable
5b3sJ-3lcrA:
undetectable		 5b3sC-3lcrA:
20.45
5b3sJ-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.88A 5iy5C-3lcrA:
undetectable
5iy5J-3lcrA:
undetectable		 5iy5C-3lcrA:
20.86
5iy5J-3lcrA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 VAL A  67
HIS A 131
ILE A 259
THR A  69
 FMT  A3613 (-4.6A)
None
None
DMS  A3092 (-3.8A)
 1.06A 5vkqA-3lcrA:
undetectable
5vkqD-3lcrA:
undetectable		 5vkqA-3lcrA:
11.03
5vkqD-3lcrA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 5 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.89A 5x19C-3lcrA:
undetectable
5x19J-3lcrA:
undetectable		 5x19C-3lcrA:
20.45
5x19J-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.90A 5x1fP-3lcrA:
undetectable
5x1fW-3lcrA:
undetectable		 5x1fP-3lcrA:
20.45
5x1fW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 5 MET A 245
TYR A 139
GLY A 135
GLY A 130
 None
 1.12A 5x7pA-3lcrA:
1.7		 5x7pA-3lcrA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		5 / 7 LEU A 229
GLN A 227
PHE A 174
LEU A 178
PHE A 182
 None
 1.40A 5z84C-3lcrA:
undetectable
5z84J-3lcrA:
undetectable		 5z84C-3lcrA:
20.45
5z84J-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.96A 5z85C-3lcrA:
undetectable
5z85J-3lcrA:
undetectable		 5z85C-3lcrA:
20.45
5z85J-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 7 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.95A 5zcqC-3lcrA:
undetectable
5zcqJ-3lcrA:
undetectable		 5zcqC-3lcrA:
20.45
5zcqJ-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS
(Streptomyces
sp.
CK4412) 		4 / 5 ILE A  61
SER A  89
ALA A 119
LEU A 145
 None
 0.93A 6dwnA-3lcrA:
undetectable		 6dwnA-3lcrA:
11.67