SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lcv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERE_E_ESTE600_1 (ESTROGEN RECEPTOR)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 8	ALA B 168 GLU B 167 LEU B 76 LEU B 95	None	0.91A	1ereE-3lcvB: undetectable	1ereE-3lcvB: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERE_F_ESTF600_1 (ESTROGEN RECEPTOR)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 8	ALA B 168 GLU B 167 LEU B 76 LEU B 95	None	0.90A	1ereF-3lcvB: undetectable	1ereF-3lcvB: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GAH_A_ACRA497_2 (GLUCOAMYLASE-471)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	ALA B 168 TRP B 143 ARG B 92 LEU B 79	None	1.12A	1gahA-3lcvB: undetectable	1gahA-3lcvB: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_A_AG2A7005_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	ASP B 182 LEU B 183 ILE B 60 ARG B 33	SAM B 301 (-3.1A) SAM B 301 (-4.0A) SAM B 301 (-4.2A) SAM B 301 ( 4.7A)	1.06A	1mt1A-3lcvB: undetectable 1mt1F-3lcvB: undetectable	1mt1A-3lcvB: 10.99 1mt1F-3lcvB: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_L_AG2L7014_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 7	ASP B 182 LEU B 183 ILE B 60 ARG B 33	SAM B 301 (-3.1A) SAM B 301 (-4.0A) SAM B 301 (-4.2A) SAM B 301 ( 4.7A)	1.03A	1n13I-3lcvB: undetectable 1n13L-3lcvB: undetectable	1n13I-3lcvB: 10.99 1n13L-3lcvB: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T88_B_CAMB2422_0 (CYTOCHROME P450-CAM)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 5	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.20A	1t88B-3lcvB: undetectable	1t88B-3lcvB: 19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UYU_B_CAMB1416_0 (CYTOCHROME P450-CAM)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 8	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.16A	1uyuB-3lcvB: undetectable	1uyuB-3lcvB: 19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KOT_A_ANWA99_0 (PROTEIN S100-A13)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 7	VAL B 26 THR B 25 THR B 18 LYS B 54	None	1.26A	2kotA-3lcvB: undetectable	2kotA-3lcvB: 13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M56_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 5	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.21A	2m56A-3lcvB: undetectable	2m56A-3lcvB: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQC_A_AG2A671_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 7	ILE B 60 ARG B 33 ASP B 182 LEU B 183	SAM B 301 (-4.2A) SAM B 301 ( 4.7A) SAM B 301 (-3.1A) SAM B 301 (-4.0A)	1.05A	2qqcB-3lcvB: undetectable 2qqcC-3lcvB: undetectable	2qqcB-3lcvB: 17.79 2qqcC-3lcvB: 11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQC_A_AG2A672_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 7	ASP B 182 LEU B 183 ILE B 60 ARG B 33	SAM B 301 (-3.1A) SAM B 301 (-4.0A) SAM B 301 (-4.2A) SAM B 301 ( 4.7A)	1.07A	2qqcA-3lcvB: undetectable 2qqcF-3lcvB: undetectable	2qqcA-3lcvB: 11.07 2qqcF-3lcvB: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQC_I_AG2I671_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 7	ASP B 182 LEU B 183 ILE B 60 ARG B 33	SAM B 301 (-3.1A) SAM B 301 (-4.0A) SAM B 301 (-4.2A) SAM B 301 ( 4.7A)	1.07A	2qqcG-3lcvB: undetectable 2qqcJ-3lcvB: undetectable	2qqcG-3lcvB: 11.07 2qqcJ-3lcvB: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQC_I_AG2I672_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 7	ASP B 182 LEU B 183 ILE B 60 ARG B 33	SAM B 301 (-3.1A) SAM B 301 (-4.0A) SAM B 301 (-4.2A) SAM B 301 ( 4.7A)	1.07A	2qqcI-3lcvB: undetectable 2qqcL-3lcvB: undetectable	2qqcI-3lcvB: 11.07 2qqcL-3lcvB: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YQZ_A_SAMA301_1 (HYPOTHETICAL PROTEIN TTHA0223)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 5	GLU B 185 ARG B 32 ASP B 186 ASP B 189	None	1.37A	2yqzA-3lcvB: 11.5	2yqzA-3lcvB: 26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YQZ_B_SAMB401_1 (HYPOTHETICAL PROTEIN TTHA0223)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 5	GLU B 185 ARG B 32 ASP B 186 ASP B 189	None	1.38A	2yqzB-3lcvB: 11.8	2yqzB-3lcvB: 26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJ8_C_SPMC500_1 (DIAMINE ACETYLTRANSFERASE 1)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	ASP B 156 LEU B 183 ASP B 131 LEU B 129	SAM B 301 (-2.9A) SAM B 301 (-4.0A) None None	1.01A	3bj8C-3lcvB: undetectable 3bj8D-3lcvB: undetectable	3bj8C-3lcvB: 20.35 3bj8D-3lcvB: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FWG_A_CAMA420_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.10A	3fwgA-3lcvB: undetectable	3fwgA-3lcvB: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FZG_A_SAMA300_0 (16S RRNA METHYLASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	8 / 12	HIS B 102 SER B 104 THR B 105 GLY B 135 ILE B 157 LEU B 198 LYS B 199 GLN B 207	SAM B 301 (-4.3A) SAM B 301 (-3.0A) SAM B 301 (-3.8A) SAM B 301 ( 4.1A) SAM B 301 (-4.2A) SAM B 301 (-4.1A) SAM B 301 (-4.9A) SAM B 301 (-3.3A)	0.58A	3fzgA-3lcvB: 19.9	3fzgA-3lcvB: 25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FZG_A_SAMA300_0 (16S RRNA METHYLASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	6 / 12	HIS B 102 SER B 104 THR B 105 ILE B 60 LEU B 198 LYS B 199	SAM B 301 (-4.3A) SAM B 301 (-3.0A) SAM B 301 (-3.8A) SAM B 301 (-4.2A) SAM B 301 (-4.1A) SAM B 301 (-4.9A)	1.45A	3fzgA-3lcvB: 19.9	3fzgA-3lcvB: 25.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3LCV_B_SAMB301_0 (SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	6 / 12	ARG B 33 ALA B 133 ILE B 157 ASP B 182 LEU B 183 LEU B 196	SAM B 301 ( 4.7A) SAM B 301 (-3.4A) SAM B 301 (-4.2A) SAM B 301 (-3.1A) SAM B 301 (-4.0A) None	1.15A	3lcvB-3lcvB: 46.2	3lcvB-3lcvB: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3LCV_B_SAMB301_0 (SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	12 / 12	ARG B 33 TYR B 61 PHE B 64 HIS B 102 SER B 104 THR B 105 ALA B 133 ILE B 157 ASP B 182 LEU B 183 LEU B 198 LYS B 199	SAM B 301 ( 4.7A) SAM B 301 (-4.9A) SAM B 301 (-3.7A) SAM B 301 (-4.3A) SAM B 301 (-3.0A) SAM B 301 (-3.8A) SAM B 301 (-3.4A) SAM B 301 (-4.2A) SAM B 301 (-3.1A) SAM B 301 (-4.0A) SAM B 301 (-4.1A) SAM B 301 (-4.9A)	0.01A	3lcvB-3lcvB: 46.2	3lcvB-3lcvB: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3LCV_B_SAMB301_1 (SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	3 / 3	ARG B 108 ASP B 156 GLN B 207	SAM B 301 (-3.0A) SAM B 301 (-2.9A) SAM B 301 (-3.3A)	0.01A	3lcvB-3lcvB: 46.2	3lcvB-3lcvB: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LTW_A_HLZA302_1 (ARYLAMINE N-ACETYLTRANSFERASE NAT)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	LEU B 198 GLU B 267 PRO B 229 ARG B 108	SAM B 301 (-4.1A) None None SAM B 301 (-3.0A)	1.31A	3ltwA-3lcvB: undetectable	3ltwA-3lcvB: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU7_C_SAMC300_1 (SAM-DEPENDENT METHYLTRANSFERASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	3 / 3	GLY B 135 ASP B 156 ASP B 182	SAM B 301 ( 4.1A) SAM B 301 (-2.9A) SAM B 301 (-3.1A)	0.38A	3ou7C-3lcvB: 11.8	3ou7C-3lcvB: 23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRH_E_CAME503_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.12A	3wrhE-3lcvB: undetectable	3wrhE-3lcvB: 19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRJ_E_CAME503_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.12A	3wrjE-3lcvB: undetectable	3wrjE-3lcvB: 19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WXO_A_NIZA802_1 (CATALASE-PEROXIDASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 8	LEU B 198 ASN B 266 GLY B 265 ILE B 264	SAM B 301 (-4.1A) None None None	0.86A	3wxoA-3lcvB: undetectable	3wxoA-3lcvB: 17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DX7_B_DM2B1104_1 (ACRIFLAVINE RESISTANCE PROTEIN B)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 8	SER B 247 GLN B 251 ILE B 224 VAL B 219	None	0.95A	4dx7B-3lcvB: undetectable	4dx7B-3lcvB: 13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EK1_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.05A	4ek1A-3lcvB: undetectable	4ek1A-3lcvB: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G3R_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.13A	4g3rA-3lcvB: undetectable	4g3rA-3lcvB: 19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IFX_A_ACTA404_0 (THIAMINE BIOSYNTHESIS LIPOPROTEIN APBE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 5	SER B 155 ARG B 130 LEU B 132 ASP B 131	None	1.46A	4ifxA-3lcvB: undetectable	4ifxA-3lcvB: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IG1_A_ACTA504_0 (FAD:PROTEIN FMN TRANSFERASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 5	SER B 155 ARG B 130 LEU B 132 ASP B 131	None	1.44A	4ig1A-3lcvB: undetectable	4ig1A-3lcvB: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JX1_E_CAME502_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 5	PHE B 115 TYR B 116 PHE B 120 ILE B 269	None	0.95A	4jx1E-3lcvB: undetectable	4jx1E-3lcvB: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L49_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 5	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.18A	4l49A-3lcvB: undetectable	4l49A-3lcvB: 19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4C_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 6	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.12A	4l4cA-3lcvB: undetectable	4l4cA-3lcvB: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4E_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 8	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.11A	4l4eA-3lcvB: undetectable	4l4eA-3lcvB: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4F_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 8	PHE B 115 TYR B 116 LEU B 196 VAL B 225	None	1.11A	4l4fA-3lcvB: undetectable	4l4fA-3lcvB: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 5	ILE B 17 PHE B 64 SER B 20 ASP B 158	None SAM B 301 (-3.7A) None None	1.38A	4rzvB-3lcvB: 0.4	4rzvB-3lcvB: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CVT_B_ACTB200_0 (N5-CARBOXYAMINOIMIDA ZOLE RIBONUCLEOTIDE MUTASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	3 / 3	ASN B 71 ALA B 73 ARG B 77	None	0.27A	5cvtB-3lcvB: undetectable	5cvtB-3lcvB: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E72_A_SAMA400_1 (N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 4	ASP B 131 GLY B 135 ASP B 156 ASP B 182	None SAM B 301 ( 4.1A) SAM B 301 (-2.9A) SAM B 301 (-3.1A)	0.81A	5e72A-3lcvB: 9.5	5e72A-3lcvB: 23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G5G_C_ACTC1740_0 (PUTATIVE XANTHINE DEHYDROGENASE YAGS FAD-BINDING SUBUNIT)	3lcv	SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM (Micromonospora zionensis)	4 / 4	VAL B 215 GLU B 214 GLY B 212 LEU B 204	None	1.23A	5g5gC-3lcvB: undetectable	5g5gC-3lcvB: 17.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERE_E_ESTE600_1","ESTROGEN RECEPTOR","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ALA B 168;GLU B 167;LEU B  76;LEU B  95","None","0.91A","1ereE-3lcvB:undetectable","1ereE-3lcvB:19.74"],["1ERE_F_ESTF600_1","ESTROGEN RECEPTOR","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ALA B 168;GLU B 167;LEU B  76;LEU B  95","None","0.90A","1ereF-3lcvB:undetectable","1ereF-3lcvB:19.74"],["1GAH_A_ACRA497_2","GLUCOAMYLASE-471","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ALA B 168;TRP B 143;ARG B  92;LEU B  79","None","1.12A","1gahA-3lcvB:undetectable","1gahA-3lcvB:19.67"],["1MT1_A_AG2A7005_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ASP B 182;LEU B 183;ILE B  60;ARG B  33","SAM B 301 (-3.1A);SAM B 301 (-4.0A);SAM B 301 (-4.2A);SAM B 301 ( 4.7A)","1.06A","1mt1A-3lcvB:undetectable;1mt1F-3lcvB:undetectable","1mt1A-3lcvB:10.99;1mt1F-3lcvB:17.79"],["1N13_L_AG2L7014_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ASP B 182;LEU B 183;ILE B  60;ARG B  33","SAM B 301 (-3.1A);SAM B 301 (-4.0A);SAM B 301 (-4.2A);SAM B 301 ( 4.7A)","1.03A","1n13I-3lcvB:undetectable;1n13L-3lcvB:undetectable","1n13I-3lcvB:10.99;1n13L-3lcvB:17.79"],["1T88_B_CAMB2422_0","CYTOCHROME P450-CAM","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.20A","1t88B-3lcvB:undetectable","1t88B-3lcvB:19.91"],["1UYU_B_CAMB1416_0","CYTOCHROME P450-CAM","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.16A","1uyuB-3lcvB:undetectable","1uyuB-3lcvB:19.91"],["2KOT_A_ANWA99_0","PROTEIN S100-A13","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"VAL B  26;THR B  25;THR B  18;LYS B  54","None","1.26A","2kotA-3lcvB:undetectable","2kotA-3lcvB:13.77"],["2M56_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.21A","2m56A-3lcvB:undetectable","2m56A-3lcvB:21.93"],["2QQC_A_AG2A671_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC)","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ILE B  60;ARG B  33;ASP B 182;LEU B 183","SAM B 301 (-4.2A);SAM B 301 ( 4.7A);SAM B 301 (-3.1A);SAM B 301 (-4.0A)","1.05A","2qqcB-3lcvB:undetectable;2qqcC-3lcvB:undetectable","2qqcB-3lcvB:17.79;2qqcC-3lcvB:11.07"],["2QQC_A_AG2A672_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC)","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ASP B 182;LEU B 183;ILE B  60;ARG B  33","SAM B 301 (-3.1A);SAM B 301 (-4.0A);SAM B 301 (-4.2A);SAM B 301 ( 4.7A)","1.07A","2qqcA-3lcvB:undetectable;2qqcF-3lcvB:undetectable","2qqcA-3lcvB:11.07;2qqcF-3lcvB:17.79"],["2QQC_I_AG2I671_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC)","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ASP B 182;LEU B 183;ILE B  60;ARG B  33","SAM B 301 (-3.1A);SAM B 301 (-4.0A);SAM B 301 (-4.2A);SAM B 301 ( 4.7A)","1.07A","2qqcG-3lcvB:undetectable;2qqcJ-3lcvB:undetectable","2qqcG-3lcvB:11.07;2qqcJ-3lcvB:17.79"],["2QQC_I_AG2I672_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC)","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ASP B 182;LEU B 183;ILE B  60;ARG B  33","SAM B 301 (-3.1A);SAM B 301 (-4.0A);SAM B 301 (-4.2A);SAM B 301 ( 4.7A)","1.07A","2qqcI-3lcvB:undetectable;2qqcL-3lcvB:undetectable","2qqcI-3lcvB:11.07;2qqcL-3lcvB:17.79"],["2YQZ_A_SAMA301_1","HYPOTHETICAL PROTEIN TTHA0223","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"GLU B 185;ARG B  32;ASP B 186;ASP B 189","None","1.37A","2yqzA-3lcvB:11.5","2yqzA-3lcvB:26.42"],["2YQZ_B_SAMB401_1","HYPOTHETICAL PROTEIN TTHA0223","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"GLU B 185;ARG B  32;ASP B 186;ASP B 189","None","1.38A","2yqzB-3lcvB:11.8","2yqzB-3lcvB:26.42"],["3BJ8_C_SPMC500_1","DIAMINE ACETYLTRANSFERASE 1;DIAMINE ACETYLTRANSFERASE 1","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ASP B 156;LEU B 183;ASP B 131;LEU B 129","SAM B 301 (-2.9A);SAM B 301 (-4.0A);None;None","1.01A","3bj8C-3lcvB:undetectable;3bj8D-3lcvB:undetectable","3bj8C-3lcvB:20.35;3bj8D-3lcvB:20.35"],["3FWG_A_CAMA420_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.10A","3fwgA-3lcvB:undetectable","3fwgA-3lcvB:21.88"],["3FZG_A_SAMA300_0","16S RRNA METHYLASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",8,"HIS B 102;SER B 104;THR B 105;GLY B 135;ILE B 157;LEU B 198;LYS B 199;GLN B 207","SAM B 301 (-4.3A);SAM B 301 (-3.0A);SAM B 301 (-3.8A);SAM B 301 ( 4.1A);SAM B 301 (-4.2A);SAM B 301 (-4.1A);SAM B 301 (-4.9A);SAM B 301 (-3.3A)","0.58A","3fzgA-3lcvB:19.9","3fzgA-3lcvB:25.09"],["3FZG_A_SAMA300_0","16S RRNA METHYLASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",6,"HIS B 102;SER B 104;THR B 105;ILE B  60;LEU B 198;LYS B 199","SAM B 301 (-4.3A);SAM B 301 (-3.0A);SAM B 301 (-3.8A);SAM B 301 (-4.2A);SAM B 301 (-4.1A);SAM B 301 (-4.9A)","1.45A","3fzgA-3lcvB:19.9","3fzgA-3lcvB:25.09"],["3LCV_B_SAMB301_0","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",6,"ARG B  33;ALA B 133;ILE B 157;ASP B 182;LEU B 183;LEU B 196","SAM B 301 ( 4.7A);SAM B 301 (-3.4A);SAM B 301 (-4.2A);SAM B 301 (-3.1A);SAM B 301 (-4.0A);None","1.15A","3lcvB-3lcvB:46.2","3lcvB-3lcvB:100.00"],["3LCV_B_SAMB301_0","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",12,"ARG B  33;TYR B  61;PHE B  64;HIS B 102;SER B 104;THR B 105;ALA B 133;ILE B 157;ASP B 182;LEU B 183;LEU B 198;LYS B 199","SAM B 301 ( 4.7A);SAM B 301 (-4.9A);SAM B 301 (-3.7A);SAM B 301 (-4.3A);SAM B 301 (-3.0A);SAM B 301 (-3.8A);SAM B 301 (-3.4A);SAM B 301 (-4.2A);SAM B 301 (-3.1A);SAM B 301 (-4.0A);SAM B 301 (-4.1A);SAM B 301 (-4.9A)","0.01A","3lcvB-3lcvB:46.2","3lcvB-3lcvB:100.00"],["3LCV_B_SAMB301_1","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",3,"ARG B 108;ASP B 156;GLN B 207","SAM B 301 (-3.0A);SAM B 301 (-2.9A);SAM B 301 (-3.3A)","0.01A","3lcvB-3lcvB:46.2","3lcvB-3lcvB:100.00"],["3LTW_A_HLZA302_1","ARYLAMINE N-ACETYLTRANSFERASE NAT","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"LEU B 198;GLU B 267;PRO B 229;ARG B 108","SAM B 301 (-4.1A);None;None;SAM B 301 (-3.0A)","1.31A","3ltwA-3lcvB:undetectable","3ltwA-3lcvB:23.12"],["3OU7_C_SAMC300_1","SAM-DEPENDENT METHYLTRANSFERASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",3,"GLY B 135;ASP B 156;ASP B 182","SAM B 301 ( 4.1A);SAM B 301 (-2.9A);SAM B 301 (-3.1A)","0.38A","3ou7C-3lcvB:11.8","3ou7C-3lcvB:23.37"],["3WRH_E_CAME503_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.12A","3wrhE-3lcvB:undetectable","3wrhE-3lcvB:19.91"],["3WRJ_E_CAME503_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.12A","3wrjE-3lcvB:undetectable","3wrjE-3lcvB:19.91"],["3WXO_A_NIZA802_1","CATALASE-PEROXIDASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"LEU B 198;ASN B 266;GLY B 265;ILE B 264","SAM B 301 (-4.1A);None;None;None","0.86A","3wxoA-3lcvB:undetectable","3wxoA-3lcvB:17.83"],["4DX7_B_DM2B1104_1","ACRIFLAVINE RESISTANCE PROTEIN B","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"SER B 247;GLN B 251;ILE B 224;VAL B 219","None","0.95A","4dx7B-3lcvB:undetectable","4dx7B-3lcvB:13.51"],["4EK1_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.05A","4ek1A-3lcvB:undetectable","4ek1A-3lcvB:21.36"],["4G3R_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.13A","4g3rA-3lcvB:undetectable","4g3rA-3lcvB:19.91"],["4IFX_A_ACTA404_0","THIAMINE BIOSYNTHESIS LIPOPROTEIN APBE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"SER B 155;ARG B 130;LEU B 132;ASP B 131","None","1.46A","4ifxA-3lcvB:undetectable","4ifxA-3lcvB:22.73"],["4IG1_A_ACTA504_0","FAD:PROTEIN FMN TRANSFERASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"SER B 155;ARG B 130;LEU B 132;ASP B 131","None","1.44A","4ig1A-3lcvB:undetectable","4ig1A-3lcvB:22.73"],["4JX1_E_CAME502_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;PHE B 120;ILE B 269","None","0.95A","4jx1E-3lcvB:undetectable","4jx1E-3lcvB:21.36"],["4L49_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.18A","4l49A-3lcvB:undetectable","4l49A-3lcvB:19.91"],["4L4C_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.12A","4l4cA-3lcvB:undetectable","4l4cA-3lcvB:20.14"],["4L4E_A_CAMA503_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.11A","4l4eA-3lcvB:undetectable","4l4eA-3lcvB:20.14"],["4L4F_A_CAMA503_0","CAMPHOR 5-MONOOXYGENASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"PHE B 115;TYR B 116;LEU B 196;VAL B 225","None","1.11A","4l4fA-3lcvB:undetectable","4l4fA-3lcvB:20.14"],["4RZV_B_032B801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ILE B  17;PHE B  64;SER B  20;ASP B 158","None;SAM B 301 (-3.7A);None;None","1.38A","4rzvB-3lcvB:0.4","4rzvB-3lcvB:19.87"],["5CVT_B_ACTB200_0","N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",3,"ASN B  71;ALA B  73;ARG B  77","None","0.27A","5cvtB-3lcvB:undetectable","5cvtB-3lcvB:21.95"],["5E72_A_SAMA400_1","N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"ASP B 131;GLY B 135;ASP B 156;ASP B 182","None;SAM B 301 ( 4.1A);SAM B 301 (-2.9A);SAM B 301 (-3.1A)","0.81A","5e72A-3lcvB:9.5","5e72A-3lcvB:23.86"],["5G5G_C_ACTC1740_0","PUTATIVE XANTHINE DEHYDROGENASE YAGS FAD-BINDING SUBUNIT","3lcv","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","Micromonospora zionensis",4,"VAL B 215;GLU B 214;GLY B 212;LEU B 204","None","1.23A","5g5gC-3lcvB:undetectable","5g5gC-3lcvB:17.03"]]