SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ld1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		3 / 3 TRP A 137
ARG A  41
PHE A  25
 None
 1.36A 1zeaH-3ld1A:
undetectable
1zeaL-3ld1A:
undetectable		 1zeaH-3ld1A:
20.56
1zeaL-3ld1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		4 / 8 VAL A 146
SER A 147
GLU A  17
ALA A 142
 None
 0.98A 2v32A-3ld1A:
undetectable
2v32B-3ld1A:
undetectable		 2v32A-3ld1A:
22.01
2v32B-3ld1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		5 / 12 LEU A 173
LEU A 225
VAL A 220
GLU A 248
PHE A 264
 None
 1.18A 2weyA-3ld1A:
undetectable		 2weyA-3ld1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		5 / 12 ARG A 152
ILE A 191
ILE A 202
PHE A 209
LEU A 235
 None
 1.16A 2ya7C-3ld1A:
undetectable		 2ya7C-3ld1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		3 / 3 ALA A  99
ARG A 103
LYS A 107
 None
 0.76A 3kp5B-3ld1A:
undetectable		 3kp5B-3ld1A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		3 / 3 PHE A 286
CYH A 331
HIS A 329
 None
 0.99A 3u9fF-3ld1A:
undetectable		 3u9fF-3ld1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		3 / 3 PHE A 286
CYH A 331
HIS A 329
 None
 0.98A 3u9fG-3ld1A:
undetectable		 3u9fG-3ld1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		3 / 3 PHE A 286
CYH A 331
HIS A 329
 None
 0.97A 3u9fL-3ld1A:
undetectable		 3u9fL-3ld1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		3 / 3 PHE A 286
CYH A 331
HIS A 329
 None
 1.03A 3u9fS-3ld1A:
undetectable		 3u9fS-3ld1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		5 / 12 PHE A 185
VAL A 158
ILE A 216
ILE A 202
VAL A 227
 None
 1.16A 4a97B-3ld1A:
undetectable
4a97C-3ld1A:
undetectable		 4a97B-3ld1A:
21.88
4a97C-3ld1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		5 / 11 GLY A 347
GLU A 287
PHE A 349
LEU A 351
ALA A 292
 None
 1.21A 4wnuA-3ld1A:
undetectable		 4wnuA-3ld1A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 3ld1 REPLICASE
POLYPROTEIN 1A
(Avian
coronavirus) 		4 / 5 ASP A  45
VAL A  11
PHE A  54
GLY A  51
 None
 1.20A 4xp6A-3ld1A:
undetectable		 4xp6A-3ld1A:
23.61