SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ld8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 3ld8 ANTIBODY FAB
FRAGMENT LIGHT CHAIN
(Cricetulus
migratorius) 		4 / 7 VAL B 169
SER B 180
ASN B 143
ASP B 173
 None
 1.33A 1hwiC-3ld8B:
undetectable		 1hwiC-3ld8B:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 3ld8 ANTIBODY FAB
FRAGMENT LIGHT CHAIN
(Cricetulus
migratorius) 		4 / 7 VAL B 169
SER B 180
ASN B 143
ASP B 173
 None
 1.33A 1hwiD-3ld8B:
undetectable		 1hwiD-3ld8B:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 6 LEU A 160
PHE A 294
TYR A 313
VAL A 297
 None
None
SO4  A 352 ( 3.8A)
None
 1.23A 1ibgH-3ld8A:
undetectable		 1ibgH-3ld8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 8 LYS A 100
THR A 193
SER A 135
GLU A 103
 SO4  A 343 ( 4.7A)
None
SO4  A 343 ( 4.9A)
None
 1.31A 1xr2B-3ld8A:
undetectable		 1xr2B-3ld8A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 7 ILE A 233
ARG A 181
SER A 128
TYR A 240
 None
 1.18A 2hc4A-3ld8A:
undetectable		 2hc4A-3ld8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 7 THR A 124
ASP A 126
SER A 182
LEU A  87
 None
 1.05A 2hdnE-3ld8A:
undetectable
2hdnF-3ld8A:
undetectable
2hdnH-3ld8A:
undetectable		 2hdnE-3ld8A:
8.94
2hdnF-3ld8A:
22.41
2hdnH-3ld8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 6 ARG A 169
THR A 193
ALA A 289
PRO A 190
 None
 1.33A 2ql8A-3ld8A:
undetectable
2ql8B-3ld8A:
undetectable		 2ql8A-3ld8A:
18.73
2ql8B-3ld8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		5 / 10 THR A 184
HIS A 187
ASP A 189
LYS A 204
HIS A 273
 None
FE  A 601 (-3.9A)
FE  A 601 (-3.3A)
None
FE  A 601 (-3.7A)
 0.74A 3kcxA-3ld8A:
16.2		 3kcxA-3ld8A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		5 / 10 TYR A 131
THR A 184
HIS A 187
ASP A 189
HIS A 273
 None
None
FE  A 601 (-3.9A)
FE  A 601 (-3.3A)
FE  A 601 (-3.7A)
 1.24A 3kcxA-3ld8A:
16.2		 3kcxA-3ld8A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		3 / 3 PRO A 171
SER A 135
ASN A 287
 None
SO4  A 343 ( 4.9A)
None
 0.86A 3lslG-3ld8A:
undetectable		 3lslG-3ld8A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		5 / 11 VAL A  71
PHE A 156
PHE A 288
GLY A 269
ASN A 293
 None
 1.25A 3owxA-3ld8A:
undetectable
3owxB-3ld8A:
undetectable		 3owxA-3ld8A:
24.64
3owxB-3ld8A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		3 / 3 TYR A 137
TYR A 150
GLU A 166
 None
None
SO4  A 344 (-4.1A)
 0.95A 3pfgA-3ld8A:
undetectable		 3pfgA-3ld8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		5 / 12 PHE A  99
GLU A 139
GLY A 138
PHE A 175
ASP A 149
 None
 1.24A 3ps9A-3ld8A:
undetectable		 3ps9A-3ld8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 5 THR A 281
GLY A 178
PRO A 180
ASN A 277
 None
 1.05A 3u8qA-3ld8A:
undetectable		 3u8qA-3ld8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 8 VAL A 302
TRP A 298
PHE A 294
PRO A 170
 None
 1.49A 3v35A-3ld8A:
undetectable		 3v35A-3ld8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 7 GLY A 192
ASP A 189
GLY A 269
HIS A 273
 None
FE  A 601 (-3.3A)
None
FE  A 601 (-3.7A)
 0.92A 4c5nA-3ld8A:
undetectable		 4c5nA-3ld8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		5 / 12 GLY A 269
ASN A 293
VAL A  71
PHE A 156
PHE A 288
 None
 1.23A 4fglA-3ld8A:
undetectable
4fglB-3ld8A:
undetectable		 4fglA-3ld8A:
24.28
4fglB-3ld8A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 8 GLU A 122
GLU A 119
TYR A 120
GLY A 178
 None
GOL  A 339 (-4.3A)
None
None
 0.82A 4fgzA-3ld8A:
undetectable
4fgzB-3ld8A:
undetectable		 4fgzA-3ld8A:
21.84
4fgzB-3ld8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 7 TYR A 117
GLN A 286
THR A 264
THR A  86
 None
 1.07A 4mbsA-3ld8A:
undetectable		 4mbsA-3ld8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		3 / 3 TYR A 117
GLY A 178
PRO A 179
 None
 0.66A 4qwpA-3ld8A:
undetectable		 4qwpA-3ld8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ld8 ANTIBODY FAB
FRAGMENT LIGHT CHAIN
BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Cricetulus
migratorius;
Homo
sapiens) 		4 / 8 ARG A  65
LEU B  29
LEU B  38
MET B   4
 None
 0.99A 4xtaB-3ld8A:
undetectable		 4xtaB-3ld8A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 7 SER A 290
SER A 194
PHE A 266
GLU A  64
 None
 1.46A 4xzkA-3ld8A:
undetectable		 4xzkA-3ld8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		5 / 11 VAL A  71
PHE A 156
PHE A 288
GLY A 269
ASN A 293
 None
 1.29A 4zvmA-3ld8A:
undetectable
4zvmB-3ld8A:
undetectable		 4zvmA-3ld8A:
24.13
4zvmB-3ld8A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ld8 ANTIBODY FAB
FRAGMENT LIGHT CHAIN
(Cricetulus
migratorius) 		4 / 6 ASP B 149
LYS B 205
HIS B 204
ILE B 150
 None
 1.15A 5a06A-3ld8B:
undetectable		 5a06A-3ld8B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ld8 ANTIBODY FAB
FRAGMENT LIGHT CHAIN
(Cricetulus
migratorius) 		4 / 5 ASP B 149
LYS B 205
HIS B 204
ILE B 150
 None
 1.20A 5a06B-3ld8B:
undetectable		 5a06B-3ld8B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ld8 ANTIBODY FAB
FRAGMENT LIGHT CHAIN
(Cricetulus
migratorius) 		4 / 5 ASP B 149
LYS B 205
HIS B 204
ILE B 150
 None
 1.20A 5a06D-3ld8B:
undetectable		 5a06D-3ld8B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ld8 ANTIBODY FAB
FRAGMENT LIGHT CHAIN
(Cricetulus
migratorius) 		4 / 5 ASP B 149
LYS B 205
HIS B 204
ILE B 150
 None
 1.20A 5a06F-3ld8B:
undetectable		 5a06F-3ld8B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		3 / 3 LYS A  21
ASP A  25
ARG A  17
 None
 0.95A 5jwaA-3ld8A:
undetectable
5jwaH-3ld8A:
undetectable		 5jwaA-3ld8A:
19.49
5jwaH-3ld8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens) 		4 / 8 PHE A  35
PRO A  39
ALA A  41
PRO A 129
 None
 0.79A 5m0oC-3ld8A:
undetectable		 5m0oC-3ld8A:
19.87