SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 174
ALA A 320
THR A 181
SER A 179
 None
 0.90A 1c9sT-3ldaA:
undetectable
1c9sU-3ldaA:
undetectable		 1c9sT-3ldaA:
11.75
1c9sU-3ldaA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 174
ALA A 320
THR A 181
SER A 179
 None
 0.90A 1gtfL-3ldaA:
undetectable
1gtfM-3ldaA:
undetectable		 1gtfL-3ldaA:
11.75
1gtfM-3ldaA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 135
ASN A 134
SER A 125
GLY A  90
ILE A  91
 None
 1.01A 1q8jB-3ldaA:
3.0		 1q8jB-3ldaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 360
LEU A 183
VAL A 323
CYH A 370
LEU A 303
 None
 1.38A 2hc4A-3ldaA:
undetectable		 2hc4A-3ldaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 THR A 355
VAL A 323
ALA A 320
GLN A 311
 None
 1.16A 2ij7C-3ldaA:
undetectable		 2ij7C-3ldaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 176
VAL A 175
CYH A 159
 None
 1.04A 3fbxA-3ldaA:
undetectable		 3fbxA-3ldaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 218
ARG A 312
ILE A 277
THR A 220
 None
 1.28A 3ia4C-3ldaA:
undetectable		 3ia4C-3ldaA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 285
GLN A 258
VAL A 279
ILE A 180
SER A 353
 None
 1.40A 4b3aA-3ldaA:
undetectable		 4b3aA-3ldaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 9 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.08A 4c9kA-3ldaA:
undetectable		 4c9kA-3ldaA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 9 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.08A 4c9kB-3ldaA:
undetectable		 4c9kB-3ldaA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 8 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.08A 4c9nA-3ldaA:
undetectable		 4c9nA-3ldaA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.07A 4c9oA-3ldaA:
undetectable		 4c9oA-3ldaA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.07A 4c9oB-3ldaA:
undetectable		 4c9oB-3ldaA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 5 THR A 223
GLN A 326
GLU A 221
THR A 220
 None
CL  A1081 ( 4.8A)
None
None
 1.34A 4eahA-3ldaA:
2.1
4eahE-3ldaA:
2.1
4eahG-3ldaA:
1.4		 4eahA-3ldaA:
23.19
4eahE-3ldaA:
23.19
4eahG-3ldaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  96
HIS A 105
ILE A  83
ALA A 266
 None
 0.85A 4eyzA-3ldaA:
undetectable		 4eyzA-3ldaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  96
HIS A 105
ILE A  83
ALA A 266
 None
 0.85A 4eyzB-3ldaA:
undetectable		 4eyzB-3ldaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  96
HIS A 105
SER A 102
ALA A 266
 None
 1.01A 4eyzB-3ldaA:
undetectable		 4eyzB-3ldaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 394
ASN A 166
CYH A 383
ASP A 168
 None
 1.19A 4feuF-3ldaA:
undetectable		 4feuF-3ldaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 394
ASN A 166
CYH A 383
ASP A 168
 None
 1.20A 4fewD-3ldaA:
undetectable		 4fewD-3ldaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 394
ASN A 166
CYH A 383
ASP A 168
 None
 1.21A 4fewF-3ldaA:
undetectable		 4fewF-3ldaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 394
ASN A 166
CYH A 383
ASP A 168
 None
 1.18A 4gkhD-3ldaA:
undetectable		 4gkhD-3ldaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 154
GLY A 174
GLY A 173
GLY A 172
LEU A 167
 None
 0.91A 4htfA-3ldaA:
4.1		 4htfA-3ldaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 154
GLY A 174
GLY A 173
GLY A 172
VAL A 322
 None
 0.81A 4htfA-3ldaA:
4.1		 4htfA-3ldaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 154
GLY A 174
GLY A 173
GLY A 172
LEU A 167
 None
 0.95A 4htfB-3ldaA:
4.1		 4htfB-3ldaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 154
GLY A 174
GLY A 173
GLY A 172
VAL A 322
 None
 0.83A 4htfB-3ldaA:
4.1		 4htfB-3ldaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 167
THR A 201
THR A 197
LEU A 198
LEU A 194
 None
 1.00A 4z90F-3ldaA:
undetectable
4z90G-3ldaA:
undetectable
4z90H-3ldaA:
undetectable
4z90I-3ldaA:
undetectable
4z90J-3ldaA:
undetectable		 4z90F-3ldaA:
22.75
4z90G-3ldaA:
22.75
4z90H-3ldaA:
22.75
4z90I-3ldaA:
22.75
4z90J-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 194
LEU A 167
THR A 201
THR A 197
LEU A 198
 None
 0.99A 4z91A-3ldaA:
1.6
4z91B-3ldaA:
undetectable
4z91C-3ldaA:
undetectable
4z91D-3ldaA:
1.6
4z91E-3ldaA:
undetectable		 4z91A-3ldaA:
22.75
4z91B-3ldaA:
22.75
4z91C-3ldaA:
22.75
4z91D-3ldaA:
22.75
4z91E-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 10 THR A 197
LEU A 198
LEU A 194
LEU A 167
THR A 201
 None
 0.98A 4z91A-3ldaA:
1.6
4z91B-3ldaA:
undetectable
4z91C-3ldaA:
undetectable
4z91D-3ldaA:
1.6
4z91E-3ldaA:
undetectable		 4z91A-3ldaA:
22.75
4z91B-3ldaA:
22.75
4z91C-3ldaA:
22.75
4z91D-3ldaA:
22.75
4z91E-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 10 THR A 201
THR A 197
LEU A 198
LEU A 194
LEU A 167
 None
 0.98A 4z91A-3ldaA:
1.6
4z91B-3ldaA:
undetectable
4z91C-3ldaA:
undetectable
4z91D-3ldaA:
1.6
4z91E-3ldaA:
undetectable		 4z91A-3ldaA:
22.75
4z91B-3ldaA:
22.75
4z91C-3ldaA:
22.75
4z91D-3ldaA:
22.75
4z91E-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 10 THR A 201
THR A 197
LEU A 198
LEU A 194
LEU A 167
 None
 1.02A 4z91A-3ldaA:
1.6
4z91B-3ldaA:
undetectable
4z91C-3ldaA:
undetectable
4z91D-3ldaA:
1.6
4z91E-3ldaA:
undetectable		 4z91A-3ldaA:
22.75
4z91B-3ldaA:
22.75
4z91C-3ldaA:
22.75
4z91D-3ldaA:
22.75
4z91E-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 167
THR A 201
THR A 197
LEU A 198
 None
 0.94A 4z91F-3ldaA:
undetectable
4z91G-3ldaA:
undetectable
4z91H-3ldaA:
undetectable
4z91I-3ldaA:
undetectable
4z91J-3ldaA:
undetectable		 4z91F-3ldaA:
22.75
4z91G-3ldaA:
22.75
4z91H-3ldaA:
22.75
4z91I-3ldaA:
22.75
4z91J-3ldaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3lda DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 212
GLY A 391
ASP A 390
GLY A 163
 None
 0.86A 5cdnA-3ldaA:
undetectable
5cdnB-3ldaA:
undetectable		 5cdnA-3ldaA:
21.72
5cdnB-3ldaA:
19.75