SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ldd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 PHE A  54
ILE A  31
LEU A  50
LEU A  79
 None
 0.80A 1eupA-3lddA:
undetectable		 1eupA-3lddA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		4 / 9 PHE A  87
ALA A  88
VAL A  91
GLU A  92
 None
 0.83A 2vufA-3lddA:
3.7		 2vufA-3lddA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ILE A  57
LEU A  28
ILE A  31
PHE A  54
THR A  86
 None
 0.90A 2w9sA-3lddA:
undetectable		 2w9sA-3lddA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ILE A  57
LEU A  28
ILE A  31
PHE A  54
THR A  86
 None
 0.92A 2w9sB-3lddA:
undetectable		 2w9sB-3lddA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ILE A  57
LEU A  28
ILE A  31
PHE A  54
THR A  86
 None
 0.81A 2w9sD-3lddA:
undetectable		 2w9sD-3lddA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ILE A  57
LEU A  28
ILE A  31
PHE A  54
THR A  86
 None
 0.79A 2w9sF-3lddA:
undetectable		 2w9sF-3lddA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A  83
ILE A  84
ILE A  57
LEU A  26
VAL A  30
 None
 0.94A 4azvA-3lddA:
undetectable		 4azvA-3lddA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 GLY A  83
VAL A  30
PRO A  67
GLU A  42
GLY A  37
 None
 1.36A 4fimA-3lddA:
undetectable		 4fimA-3lddA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ldd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 LEU A  71
ILE A  41
TYR A  33
 None
 0.61A 5uunB-3lddA:
undetectable		 5uunB-3lddA:
16.85