SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ldg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		5 / 12 ASP A 200
LEU A 287
GLY A 280
ALA A 183
ILE A 187
 None
 0.87A 1pbkA-3ldgA:
undetectable		 1pbkA-3ldgA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		4 / 8 PHE A 295
LEU A 304
GLY A 261
ASP A 200
 None
 0.99A 1rmtC-3ldgA:
2.2		 1rmtC-3ldgA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		5 / 12 LEU A 292
ILE A 341
PHE A 348
GLN A 339
PHE A 331
 SAH  A 385 (-3.8A)
None
None
None
None
 1.14A 1xomA-3ldgA:
undetectable		 1xomA-3ldgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		5 / 12 LEU A 292
ILE A 341
PHE A 348
GLN A 339
PHE A 331
 SAH  A 385 (-3.8A)
None
None
None
None
 1.17A 1xomB-3ldgA:
undetectable		 1xomB-3ldgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		5 / 10 PHE A 295
LEU A 304
GLY A 261
ASP A 200
THR A 330
 None
 1.30A 2b82A-3ldgA:
undetectable		 2b82A-3ldgA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		5 / 12 THR A 202
GLY A 204
ASP A 263
GLN A 293
ASN A 307
 SAH  A 385 (-3.9A)
SAH  A 385 (-3.4A)
SAH  A 385 (-2.8A)
SAH  A 385 (-3.1A)
SAH  A 385 (-4.3A)
 0.73A 3eeyJ-3ldgA:
11.1		 3eeyJ-3ldgA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		4 / 7 PHE A 331
GLY A 328
PHE A 352
PHE A 340
 None
 1.07A 3ko0D-3ldgA:
undetectable
3ko0E-3ldgA:
undetectable		 3ko0D-3ldgA:
15.06
3ko0E-3ldgA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		3 / 3 ASP A 248
ARG A 244
ALA A 247
 None
 0.72A 3mbgC-3ldgA:
undetectable		 3mbgC-3ldgA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		3 / 3 TYR A 363
ASP A 370
ASP A 347
 None
 0.81A 3ou6B-3ldgA:
8.1		 3ou6B-3ldgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		4 / 7 ILE A 341
PHE A 348
GLN A 339
PHE A 331
 None
 1.17A 3tvxB-3ldgA:
undetectable		 3tvxB-3ldgA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		8 / 12 ILE A 178
GLY A 204
SER A 205
THR A 207
ASP A 265
ASN A 307
PRO A 309
LEU A 323
 SAH  A 385 (-4.2A)
SAH  A 385 (-3.4A)
SAH  A 385 (-2.6A)
SAH  A 385 (-3.5A)
None
SAH  A 385 (-4.3A)
SAH  A 385 (-4.2A)
None
 0.53A 3v8vA-3ldgA:
40.8		 3v8vA-3ldgA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		6 / 12 PRO A 177
GLY A 204
SER A 205
THR A 207
ASP A 265
LEU A 315
 SAH  A 385 (-4.5A)
SAH  A 385 (-3.4A)
SAH  A 385 (-2.6A)
SAH  A 385 (-3.5A)
None
None
 1.39A 3v8vA-3ldgA:
40.8		 3v8vA-3ldgA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		6 / 12 PRO A 177
ILE A 178
GLY A 204
SER A 205
THR A 207
ASP A 265
 SAH  A 385 (-4.5A)
SAH  A 385 (-4.2A)
SAH  A 385 (-3.4A)
SAH  A 385 (-2.6A)
SAH  A 385 (-3.5A)
None
 1.19A 3v8vA-3ldgA:
40.8		 3v8vA-3ldgA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		6 / 11 GLY A 204
ASP A 263
ASP A 265
ASN A 307
PRO A 309
LEU A 323
 SAH  A 385 (-3.4A)
SAH  A 385 (-2.8A)
None
SAH  A 385 (-4.3A)
SAH  A 385 (-4.2A)
None
 0.46A 3v8vB-3ldgA:
37.2		 3v8vB-3ldgA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		4 / 5 PHE A 198
GLY A 206
ILE A 259
VAL A 285
 None
 0.84A 3wrkA-3ldgA:
undetectable		 3wrkA-3ldgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		5 / 9 LEU A 257
ASP A 200
VAL A 285
LEU A 287
ILE A 259
 None
 1.38A 3wsjA-3ldgA:
undetectable		 3wsjA-3ldgA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		5 / 11 ASP A 200
GLY A 204
ASP A 263
ASN A 307
PRO A 309
 None
SAH  A 385 (-3.4A)
SAH  A 385 (-2.8A)
SAH  A 385 (-4.3A)
SAH  A 385 (-4.2A)
 0.66A 4dcmA-3ldgA:
10.7		 4dcmA-3ldgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		5 / 10 ALA A 118
ILE A 114
ILE A 111
LEU A 148
ILE A 146
 None
 1.16A 4dtaA-3ldgA:
undetectable		 4dtaA-3ldgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		4 / 7 GLU A 278
TYR A 169
ARG A 170
GLY A 206
 None
None
SAH  A 385 ( 4.8A)
None
 1.04A 4fgzA-3ldgA:
9.6		 4fgzA-3ldgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		4 / 8 LEU A 287
ASN A 275
ALA A 276
VAL A 279
 None
 0.86A 4zbqA-3ldgA:
undetectable		 4zbqA-3ldgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		4 / 4 LEU A 123
LEU A  89
GLY A  90
GLU A 137
 None
 1.21A 5hhjA-3ldgA:
undetectable		 5hhjA-3ldgA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		5 / 10 ALA A 213
ILE A 186
ILE A 305
VAL A 303
PHE A 198
 None
 1.14A 5nukA-3ldgA:
undetectable		 5nukA-3ldgA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472
(Streptococcus
mutans) 		3 / 3 ARG A 154
LYS A  60
ARG A 167
 None
 1.23A 6c06D-3ldgA:
undetectable		 6c06D-3ldgA:
undetectable