SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ldh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		4 / 7 LEU A 112
ASP A 144
THR A 143
TRP A 231
 None
 1.21A 1v55C-3ldhA:
undetectable
1v55N-3ldhA:
undetectable
1v55P-3ldhA:
undetectable		 1v55C-3ldhA:
19.24
1v55N-3ldhA:
21.37
1v55P-3ldhA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		5 / 12 LEU A  66
LEU A  41
GLY A  33
ALA A  35
ALA A 248
 None
 1.16A 2bm9C-3ldhA:
2.5		 2bm9C-3ldhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		4 / 6 ARG A 267
THR A 260
ASN A  22
ASP A  47
 None
 1.02A 2okcA-3ldhA:
4.1		 2okcA-3ldhA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		5 / 12 GLN A 314
VAL A 285
LEU A 322
ILE A 281
THR A 321
 None
 1.33A 3elzA-3ldhA:
undetectable		 3elzA-3ldhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		5 / 11 GLN A 314
VAL A 285
LEU A 322
ILE A 281
THR A 321
 None
 1.39A 3elzB-3ldhA:
undetectable		 3elzB-3ldhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		5 / 12 GLN A 314
VAL A 285
LEU A 322
ILE A 281
THR A 321
 None
 1.33A 3elzC-3ldhA:
undetectable		 3elzC-3ldhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		5 / 12 GLN A 314
VAL A 285
LEU A 322
ILE A 281
THR A 321
 None
 1.35A 3em0B-3ldhA:
undetectable		 3em0B-3ldhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		5 / 11 THR A  25
VAL A  95
ILE A  96
ASN A 126
ILE A 127
 None
 1.26A 3kpcA-3ldhA:
undetectable		 3kpcA-3ldhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		5 / 11 ILE A 281
SER A 288
LEU A 287
LEU A 322
THR A 320
 None
 1.19A 3kw2A-3ldhA:
undetectable		 3kw2A-3ldhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		4 / 7 LEU A  45
LEU A  51
ASP A  36
MET A  34
 None
 0.80A 3rgfA-3ldhA:
undetectable		 3rgfA-3ldhA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		5 / 9 ASP A  53
TYR A  85
ARG A 101
ILE A 119
ILE A 123
 NAD  A 332 (-2.7A)
None
NAD  A 332 (-2.8A)
NAD  A 332 ( 4.1A)
NAD  A 332 ( 4.8A)
 1.38A 4oknB-3ldhA:
39.3		 4oknB-3ldhA:
64.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		5 / 9 ASP A  53
VAL A  54
TYR A  85
ILE A 119
ILE A 123
 NAD  A 332 (-2.7A)
None
None
NAD  A 332 ( 4.1A)
NAD  A 332 ( 4.8A)
 0.74A 4oknB-3ldhA:
39.3		 4oknB-3ldhA:
64.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		4 / 6 MET A 274
ILE A  96
ILE A 127
VAL A  94
 None
 1.02A 4olmA-3ldhA:
undetectable		 4olmA-3ldhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		4 / 8 ASP A 144
THR A 143
TRP A 231
LEU A 112
 None
 1.09A 5b1bA-3ldhA:
undetectable
5b1bC-3ldhA:
undetectable
5b1bP-3ldhA:
undetectable		 5b1bA-3ldhA:
21.37
5b1bC-3ldhA:
19.24
5b1bP-3ldhA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		4 / 6 SER A  88
GLY A  33
ASP A  36
GLY A  28
 None
None
None
NAD  A 332 (-1.8A)
 0.94A 5cdnR-3ldhA:
undetectable
5cdnS-3ldhA:
undetectable		 5cdnR-3ldhA:
20.40
5cdnS-3ldhA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		4 / 6 SER A  88
GLY A  33
ASP A  36
GLY A  28
 None
None
None
NAD  A 332 (-1.8A)
 0.75A 5cdpA-3ldhA:
undetectable
5cdpB-3ldhA:
undetectable		 5cdpA-3ldhA:
20.36
5cdpB-3ldhA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		3 / 3 VAL A 271
LEU A  45
MET A 262
 None
 0.90A 5ikrA-3ldhA:
undetectable		 5ikrA-3ldhA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ldh LACTATE
DEHYDROGENASE
(Squalus
acanthias) 		4 / 7 ASP A 144
THR A 143
TRP A 231
LEU A 112
 None
 1.09A 6nmfA-3ldhA:
undetectable
6nmfC-3ldhA:
undetectable
6nmfP-3ldhA:
undetectable		 6nmfA-3ldhA:
21.37
6nmfC-3ldhA:
19.24
6nmfP-3ldhA:
19.24