SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ldu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 8 ASP A 289
THR A 291
PRO A 307
LEU A 321
 GTP  A 383 ( 3.8A)
GTP  A 383 ( 4.3A)
GTP  A 383 (-3.7A)
None
 0.89A 1hmyA-3lduA:
6.6		 1hmyA-3lduA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 GLY A 202
ILE A 262
ASP A 263
ASP A 289
ASN A 305
PRO A 307
 GTP  A 383 (-2.6A)
GTP  A 383 (-4.2A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
 0.89A 1qaoA-3lduA:
10.2		 1qaoA-3lduA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		3 / 3 PRO A 199
ASP A 261
ASP A 289
 None
GTP  A 383 (-3.0A)
GTP  A 383 ( 3.8A)
 0.77A 1sqfA-3lduA:
10.6		 1sqfA-3lduA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 7 THR A  41
LEU A   6
VAL A 241
ILE A 237
 None
 0.94A 1t87B-3lduA:
undetectable		 1t87B-3lduA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1302_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 5 SER A 154
LYS A  62
TRP A  83
ALA A  64
 None
 1.29A 1ukbA-3lduA:
0.0		 1ukbA-3lduA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 7 TYR A 186
ARG A  54
TYR A  27
TYR A  39
 None
 0.94A 2ajvH-3lduA:
undetectable
2ajvL-3lduA:
undetectable		 2ajvH-3lduA:
16.33
2ajvL-3lduA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 GLY A 202
ASP A 263
ASP A 289
PRO A 307
LEU A 321
 GTP  A 383 (-2.6A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
None
 0.92A 2hmyB-3lduA:
6.2		 2hmyB-3lduA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 8 GLU A  33
LYS A  62
ILE A   7
GLU A  65
 None
 0.84A 2j9dJ-3lduA:
3.7
2j9dK-3lduA:
3.5
2j9dL-3lduA:
3.1		 2j9dJ-3lduA:
15.32
2j9dK-3lduA:
15.32
2j9dL-3lduA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 8 ILE A  87
LYS A 116
ILE A 119
GLU A 135
 None
 0.88A 2j9dJ-3lduA:
3.7
2j9dK-3lduA:
3.5
2j9dL-3lduA:
3.1		 2j9dJ-3lduA:
15.32
2j9dK-3lduA:
15.32
2j9dL-3lduA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 8 LYS A  62
ILE A   7
GLU A  65
GLU A  33
 None
 0.81A 2j9dJ-3lduA:
3.7
2j9dK-3lduA:
3.5
2j9dL-3lduA:
3.1		 2j9dJ-3lduA:
15.32
2j9dK-3lduA:
15.32
2j9dL-3lduA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 ASP A 198
GLY A 202
ILE A 262
ASP A 263
ASN A 305
LEU A 321
 None
GTP  A 383 (-2.6A)
GTP  A 383 (-4.2A)
None
GTP  A 383 (-4.2A)
None
 0.89A 2nxeA-3lduA:
10.6		 2nxeA-3lduA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 198
GLY A 202
ILE A 262
ASP A 263
ASN A 305
 None
GTP  A 383 (-2.6A)
GTP  A 383 (-4.2A)
None
GTP  A 383 (-4.2A)
 0.83A 2nxeB-3lduA:
7.2		 2nxeB-3lduA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ALA A 290
PRO A 307
PRO A 175
GLY A 202
THR A 205
 GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-4.3A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.58A 2zifA-3lduA:
undetectable		 2zifA-3lduA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 198
ASP A 261
ILE A 262
ASP A 263
LEU A 321
 None
GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
None
None
 0.59A 3cjtC-3lduA:
10.6		 3cjtC-3lduA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ILE A  81
PHE A 145
VAL A 144
VAL A 111
VAL A 115
 None
 1.20A 3iw1A-3lduA:
undetectable		 3iw1A-3lduA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ILE A 206
ASP A 261
ASP A 289
ASN A 305
PRO A 307
 None
GTP  A 383 (-3.0A)
GTP  A 383 ( 3.8A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
 0.88A 3q87B-3lduA:
10.5		 3q87B-3lduA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 MET A 200
GLY A 202
ALA A 290
ASN A 305
PRO A 307
LEU A 321
 GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.7A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.60A 3tm4A-3lduA:
33.1		 3tm4A-3lduA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ALA A 174
GLY A 202
ALA A 290
ASN A 305
LEU A 321
 GTP  A 383 (-4.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.7A)
GTP  A 383 (-4.2A)
None
 0.88A 3tm4B-3lduA:
33.3		 3tm4B-3lduA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 MET A 200
GLY A 202
ALA A 290
ASN A 305
PRO A 307
LEU A 321
 GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.7A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.62A 3tm4B-3lduA:
33.3		 3tm4B-3lduA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		3 / 3 PRO A 189
THR A 188
LEU A 196
 None
 0.80A 3ttrA-3lduA:
undetectable		 3ttrA-3lduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		7 / 12 ILE A 176
MET A 200
GLY A 202
SER A 203
THR A 205
ASN A 305
LEU A 325
 GTP  A 383 (-3.8A)
GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
GTP  A 383 (-4.2A)
None
 1.30A 3v8vA-3lduA:
41.6		 3v8vA-3lduA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		9 / 12 ILE A 176
MET A 200
GLY A 202
SER A 203
THR A 205
ASP A 263
ASN A 305
PRO A 307
LEU A 321
 GTP  A 383 (-3.8A)
GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
None
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.66A 3v8vA-3lduA:
41.6		 3v8vA-3lduA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		8 / 11 MET A 200
GLY A 202
ASP A 261
ASP A 263
ASP A 289
ASN A 305
PRO A 307
LEU A 321
 GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.0A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.61A 3v8vB-3lduA:
37.4		 3v8vB-3lduA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 11 MET A 200
GLY A 202
ASP A 261
ASP A 289
ASN A 305
LEU A 325
 GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.0A)
GTP  A 383 ( 3.8A)
GTP  A 383 (-4.2A)
None
 1.16A 3v8vB-3lduA:
37.4		 3v8vB-3lduA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 11 ASP A 198
GLY A 202
ILE A 206
ASP A 261
ASN A 305
 None
GTP  A 383 (-2.6A)
None
GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
 0.76A 4dcmA-3lduA:
10.5		 4dcmA-3lduA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 11 GLY A 202
ILE A 206
ASP A 261
ASN A 305
PRO A 307
 GTP  A 383 (-2.6A)
None
GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
 0.54A 4dcmA-3lduA:
10.5		 4dcmA-3lduA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 7 ASP A 156
THR A 157
PHE A 143
SER A 154
 None
 1.44A 4o4dA-3lduA:
0.3		 4o4dA-3lduA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 GLY A 202
ASP A 261
ILE A 262
PRO A 307
TYR A 308
 GTP  A 383 (-2.6A)
GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.59A 4rtsA-3lduA:
10.9		 4rtsA-3lduA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 4 ILE A  87
ARG A 231
TYR A 140
GLU A 138
 None
None
FMT  A 384 (-4.9A)
None
 1.22A 4zzbD-3lduA:
undetectable		 4zzbD-3lduA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 5 ILE A  87
ARG A 231
TYR A 140
GLU A 138
 None
None
FMT  A 384 (-4.9A)
None
 1.28A 4zzcE-3lduA:
undetectable		 4zzcE-3lduA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 6 TYR A 338
ILE A 206
ASP A 198
PRO A 199
 None
 0.85A 5cu6A-3lduA:
undetectable		 5cu6A-3lduA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 ILE A 206
ILE A 262
ALA A 290
THR A 304
PRO A 307
LEU A 321
 None
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
GTP  A 383 (-3.7A)
None
 0.52A 5e72A-3lduA:
13.9		 5e72A-3lduA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 4 ASP A 198
GLY A 202
ASP A 261
ASP A 289
 None
GTP  A 383 (-2.6A)
GTP  A 383 (-3.0A)
GTP  A 383 ( 3.8A)
 0.35A 5e72A-3lduA:
13.9		 5e72A-3lduA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 7 PHE A 293
ILE A 302
LEU A 325
GLY A 326
 GOL  A 387 (-4.5A)
None
None
None
 0.86A 5h3aB-3lduA:
undetectable		 5h3aB-3lduA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.57A 5hfjA-3lduA:
2.4		 5hfjA-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ALA A 290
PRO A 307
GLY A 202
SER A 203
THR A 205
 GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
 0.75A 5hfjB-3lduA:
2.0		 5hfjB-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.55A 5hfjC-3lduA:
2.3		 5hfjC-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
SER A 203
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
 0.69A 5hfjD-3lduA:
2.3		 5hfjD-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
GLY A 202
SER A 203
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
 0.45A 5hfjE-3lduA:
2.0		 5hfjE-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
SER A 203
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
 0.74A 5hfjF-3lduA:
2.1		 5hfjF-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.54A 5hfjH-3lduA:
2.1		 5hfjH-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 GLY A 363
ASN A 362
HIS A 163
ALA A 181
SER A   8
 None
 0.93A 5igyA-3lduA:
undetectable		 5igyA-3lduA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 MET A 217
SER A 253
TYR A 282
PHE A 255
ARG A  54
 None
 1.44A 5vsdB-3lduA:
undetectable		 5vsdB-3lduA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 6 LYS A 359
LEU A 360
PHE A  11
LEU A 184
 None
 1.13A 5x19P-3lduA:
undetectable		 5x19P-3lduA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 6 PHE A 293
ILE A 302
LEU A 325
GLY A 326
 GOL  A 387 (-4.5A)
None
None
None
 0.92A 5x5qE-3lduA:
undetectable		 5x5qE-3lduA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 261
ILE A 262
ASP A 263
ASP A 289
ALA A 290
 GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
 0.86A 6bq4A-3lduA:
8.4		 6bq4A-3lduA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 261
ILE A 262
ASP A 263
ASP A 289
ALA A 290
 GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
 0.88A 6bq4B-3lduA:
8.3		 6bq4B-3lduA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 6 ALA A 182
GLY A 204
ILE A 257
PHE A 255
 None
GTP  A 383 ( 4.3A)
None
None
 0.91A 6f8cA-3lduA:
1.1		 6f8cA-3lduA:
12.95