SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ldz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1
(Homo
sapiens) 		4 / 7 TRP A 115
SER A  86
CYH A  85
ILE A 128
 None
 1.14A 2xz5A-3ldzA:
undetectable
2xz5B-3ldzA:
undetectable		 2xz5A-3ldzA:
17.94
2xz5B-3ldzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1
(Homo
sapiens) 		3 / 3 CYH A  46
ASN A   7
LYS A  35
 None
 1.44A 4k50A-3ldzA:
undetectable		 4k50A-3ldzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1
(Homo
sapiens) 		4 / 8 LEU A 111
GLY A  70
ALA A  71
SER A  74
 None
 0.65A 5f1aA-3ldzA:
undetectable		 5f1aA-3ldzA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1
(Homo
sapiens) 		4 / 7 LEU A 111
GLY A  70
ALA A  71
SER A  74
 None
 0.56A 5f1aB-3ldzA:
undetectable		 5f1aB-3ldzA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1
(Homo
sapiens) 		4 / 5 CYH A  46
CYH A  72
LEU A  68
ASP A  12
 None
 1.36A 5mafA-3ldzA:
undetectable		 5mafA-3ldzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1
(Homo
sapiens) 		5 / 9 ILE A  29
ALA A  71
GLY A  70
LEU A  69
GLY A  77
 None
 1.04A 6nm4B-3ldzA:
undetectable		 6nm4B-3ldzA:
20.21