SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3le1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		5 / 10 LEU A  77
ALA A  73
LEU A  63
LYS A  45
ALA A  44
 None
 1.37A 1ie4A-3le1A:
undetectable
1ie4C-3le1A:
undetectable		 1ie4A-3le1A:
22.13
1ie4C-3le1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		5 / 10 LYS A  45
ALA A  44
LEU A  77
ALA A  73
LEU A  63
 None
 1.22A 1ie4A-3le1A:
undetectable
1ie4C-3le1A:
undetectable		 1ie4A-3le1A:
22.13
1ie4C-3le1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		5 / 11 LEU A  63
GLU A  82
VAL A  78
ILE A  81
LEU A  53
 None
 0.92A 1mrqA-3le1A:
undetectable		 1mrqA-3le1A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		5 / 11 LEU A  77
ALA A  65
LEU A  63
LYS A  45
ALA A  44
 None
 1.15A 1tz8A-3le1A:
undetectable
1tz8B-3le1A:
undetectable		 1tz8A-3le1A:
24.22
1tz8B-3le1A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		5 / 11 LYS A  45
ALA A  44
LEU A  77
ALA A  65
LEU A  63
 None
 1.14A 1tz8A-3le1A:
undetectable
1tz8B-3le1A:
undetectable		 1tz8A-3le1A:
24.22
1tz8B-3le1A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A  50
LEU A  53
ALA A  19
GLY A  13
SER A  56
 None
 1.31A 2a58A-3le1A:
undetectable
2a58B-3le1A:
undetectable		 2a58A-3le1A:
20.13
2a58B-3le1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A  50
LEU A  53
ALA A  19
GLY A  13
SER A  56
 None
 1.31A 2a58B-3le1A:
undetectable
2a58C-3le1A:
undetectable		 2a58B-3le1A:
20.13
2a58C-3le1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A  50
LEU A  53
ALA A  19
GLY A  13
SER A  56
 None
 1.31A 2a58D-3le1A:
undetectable
2a58E-3le1A:
undetectable		 2a58D-3le1A:
20.13
2a58E-3le1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		3 / 3 SER A  31
GLU A  72
ASP A  68
 None
 0.71A 2zthA-3le1A:
undetectable		 2zthA-3le1A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		3 / 3 SER A  31
GLU A  72
ASP A  68
 None
 0.66A 3bwmA-3le1A:
undetectable		 3bwmA-3le1A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		3 / 3 SER A  31
GLU A  72
ASP A  68
 None
 0.65A 3bwyA-3le1A:
undetectable		 3bwyA-3le1A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		3 / 3 SER A  31
GLU A  72
ASP A  68
 None
 0.72A 4xudA-3le1A:
undetectable		 4xudA-3le1A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		4 / 6 LEU A  80
LEU A  63
PHE A  85
LEU A  14
 None
 1.00A 5gs4A-3le1A:
undetectable		 5gs4A-3le1A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS
(Caldanaerobacter
subterraneus) 		4 / 5 LEU A  80
LEU A  63
PHE A  85
LEU A  14
 None
 0.94A 5gtrA-3le1A:
undetectable		 5gtrA-3le1A:
15.97