SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3le2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		3 / 3 ASP A 216
ASP A 242
LYS A 253
 None
None
SO4  A 392 ( 4.8A)
 0.98A 1lqtB-3le2A:
undetectable		 1lqtB-3le2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		3 / 3 ASP A 216
ASP A 242
LYS A 253
 None
None
SO4  A 392 ( 4.8A)
 0.99A 1lquB-3le2A:
undetectable		 1lquB-3le2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		5 / 12 GLY A  48
VAL A  41
ILE A 100
ALA A 120
ILE A  44
 None
 0.90A 1rl8A-3le2A:
undetectable		 1rl8A-3le2A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		4 / 8 LEU A 307
PHE A 127
LEU A 154
SER A 289
 None
 0.91A 1wrlC-3le2A:
undetectable
1wrlD-3le2A:
undetectable		 1wrlC-3le2A:
13.37
1wrlD-3le2A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		4 / 8 VAL A 291
VAL A  21
LEU A 292
HIS A 327
 None
 0.67A 2ddwA-3le2A:
undetectable		 2ddwA-3le2A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		4 / 5 ILE A  45
PHE A  60
VAL A 371
PHE A 286
 None
 1.28A 2ygnA-3le2A:
undetectable		 2ygnA-3le2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		4 / 5 ILE A 277
PHE A 275
ASP A 361
GLU A 274
 None
 1.03A 3kp6A-3le2A:
undetectable
3kp6B-3le2A:
undetectable		 3kp6A-3le2A:
18.11
3kp6B-3le2A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		4 / 5 VAL A  13
PHE A  33
ILE A  38
PHE A 286
 None
 0.97A 3owxB-3le2A:
undetectable		 3owxB-3le2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		5 / 9 VAL A 372
PHE A 282
ILE A  32
GLY A 384
PHE A 280
 None
 1.29A 3t3rB-3le2A:
undetectable		 3t3rB-3le2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		5 / 9 VAL A 372
PHE A 282
ILE A  32
GLY A 384
PHE A 280
 None
 1.33A 3t3rC-3le2A:
undetectable		 3t3rC-3le2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		5 / 10 VAL A 372
PHE A 282
ILE A  32
GLY A 384
PHE A 280
 None
 1.21A 3t3rD-3le2A:
undetectable		 3t3rD-3le2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		4 / 8 VAL A 372
ILE A  32
PHE A 382
ILE A 331
 None
 0.77A 3warA-3le2A:
undetectable		 3warA-3le2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		5 / 12 PHE A 382
PHE A  33
LEU A 292
GLN A  10
ALA A  36
 None
 1.39A 4a83A-3le2A:
undetectable		 4a83A-3le2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		3 / 3 LYS A 107
PRO A 108
SER A 109
 None
 0.31A 4k50I-3le2A:
undetectable		 4k50I-3le2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		5 / 9 LEU A 261
ASN A 375
VAL A 371
VAL A 380
LEU A 381
 None
ACT  A 393 ( 4.9A)
None
None
None
 1.09A 4qd3A-3le2A:
undetectable		 4qd3A-3le2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 3le2 SERPIN-ZX
(Arabidopsis
thaliana) 		5 / 9 PHE A 326
ALA A 168
PHE A 167
VAL A 134
SER A 158
 None
 1.48A 4z69A-3le2A:
undetectable		 4z69A-3le2A:
20.47