SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		4 / 4 LEU A  22
SER A  27
LEU A  37
LEU A  36
 None
 0.99A 1yajA-3lecA:
3.0		 1yajA-3lecA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		4 / 5 LEU A  22
SER A  27
LEU A  37
LEU A  36
 None
 1.04A 1yajD-3lecA:
3.2		 1yajD-3lecA:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		10 / 12 ARG A   8
LEU A   9
GLY A  26
VAL A  50
PRO A  54
GLY A  78
GLY A  95
MET A  96
LEU A 100
ILE A 104
 None
None
None
None
None
None
None
None
SO4  A 229 ( 4.7A)
None
 0.54A 3ku1A-3lecA:
33.0		 3ku1A-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		10 / 12 ARG A   8
LEU A   9
GLY A  26
VAL A  50
PRO A  54
GLY A  78
GLY A  95
MET A  96
LEU A 100
ILE A 104
 None
None
None
None
None
None
None
None
SO4  A 229 ( 4.7A)
None
 0.51A 3ku1C-3lecA:
32.8		 3ku1C-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		6 / 12 GLY A  26
ASP A  28
GLY A  78
MET A  96
LEU A 100
ILE A 104
 None
None
None
None
SO4  A 229 ( 4.7A)
None
 1.23A 3ku1C-3lecA:
32.8		 3ku1C-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		8 / 12 ARG A   8
LEU A   9
GLY A  26
VAL A  50
PRO A  54
GLY A  78
GLY A  95
ILE A 104
 None
 0.51A 3ku1G-3lecA:
32.9		 3ku1G-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		8 / 12 ARG A   8
LEU A   9
GLY A  26
VAL A  50
PRO A  54
GLY A  95
LEU A 100
ILE A 104
 None
None
None
None
None
None
SO4  A 229 ( 4.7A)
None
 0.54A 3ku1G-3lecA:
32.9		 3ku1G-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 GLY A  26
ASP A  28
VAL A  50
GLY A  78
ILE A 104
 None
 0.84A 3ku1G-3lecA:
32.9		 3ku1G-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 12 GLY A  26
ASP A  28
VAL A  50
LEU A 100
ILE A 104
 None
None
None
SO4  A 229 ( 4.7A)
None
 0.84A 3ku1G-3lecA:
32.9		 3ku1G-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		10 / 12 ARG A   8
LEU A   9
GLY A  26
VAL A  50
VAL A  51
PRO A  54
GLY A  78
MET A  96
LEU A 100
ILE A 104
 None
None
None
None
None
None
None
None
SO4  A 229 ( 4.7A)
None
 0.65A 3ku1H-3lecA:
18.4		 3ku1H-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		7 / 12 GLY A  26
ASP A  28
VAL A  50
GLY A  78
MET A  96
LEU A 100
ILE A 104
 None
None
None
None
None
SO4  A 229 ( 4.7A)
None
 0.95A 3ku1H-3lecA:
18.4		 3ku1H-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		6 / 12 GLY A  48
VAL A  50
VAL A  51
PRO A  54
GLY A  78
ILE A 104
 None
 1.42A 3ku1H-3lecA:
18.4		 3ku1H-3lecA:
61.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		5 / 11 GLY A  26
ILE A  46
ASP A  72
VAL A  73
PRO A  33
 None
 1.25A 5hjiA-3lecA:
11.3		 5hjiA-3lecA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN
(Streptococcus
agalactiae) 		4 / 6 PHE A  35
PRO A  33
ALA A  13
THR A  92
 None
 1.16A 5t7bA-3lecA:
undetectable		 5t7bA-3lecA:
13.22