SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3leo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RU9_H_BEZH601_0 (IMMUNOGLOBULIN IGG2A, HEAVY CHAIN IMMUNOGLOBULIN IGG2A, LIGHT CHAIN)	3leo	LEUKOTRIENE C4 SYNTHASE (Homo sapiens)	5 / 9	ALA A 10 LEU A 14 GLY A 15 PHE A 63 GLY A 83	PAM A 215 (-3.7A) PAM A 215 (-3.9A) None None None	1.34A	1ru9H-3leoA: undetectable 1ru9L-3leoA: undetectable	1ru9H-3leoA: 21.33 1ru9L-3leoA: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RUA_H_BEZH601_0 (IMMUNOGLOBULIN IGG2A, HEAVY CHAIN IMMUNOGLOBULIN IGG2A, LIGHT CHAIN)	3leo	LEUKOTRIENE C4 SYNTHASE (Homo sapiens)	5 / 10	ALA A 10 LEU A 14 GLY A 15 PHE A 63 GLY A 83	PAM A 215 (-3.7A) PAM A 215 (-3.9A) None None None	1.35A	1ruaH-3leoA: undetectable 1ruaL-3leoA: undetectable	1ruaH-3leoA: 21.33 1ruaL-3leoA: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZN7_A_DESA601_1 (ESTROGEN RECEPTOR)	3leo	LEUKOTRIENE C4 SYNTHASE (Homo sapiens)	5 / 12	LEU A 81 ALA A 79 LEU A 8 LEU A 7 LEU A 118	PAM A 215 ( 4.5A) None None PAM A 215 ( 4.1A) None	1.13A	4zn7A-3leoA: undetectable	4zn7A-3leoA: 21.69

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RU9_H_BEZH601_0","IMMUNOGLOBULIN IGG2A, HEAVY CHAIN;IMMUNOGLOBULIN IGG2A, LIGHT CHAIN","3leo","LEUKOTRIENE C4 SYNTHASE","Homo sapiens",5,"ALA A  10;LEU A  14;GLY A  15;PHE A  63;GLY A  83","PAM A 215 (-3.7A);PAM A 215 (-3.9A);None;None;None","1.34A","1ru9H-3leoA:undetectable;1ru9L-3leoA:undetectable","1ru9H-3leoA:21.33;1ru9L-3leoA:16.44"],["1RUA_H_BEZH601_0","IMMUNOGLOBULIN IGG2A, HEAVY CHAIN;IMMUNOGLOBULIN IGG2A, LIGHT CHAIN","3leo","LEUKOTRIENE C4 SYNTHASE","Homo sapiens",5,"ALA A  10;LEU A  14;GLY A  15;PHE A  63;GLY A  83","PAM A 215 (-3.7A);PAM A 215 (-3.9A);None;None;None","1.35A","1ruaH-3leoA:undetectable;1ruaL-3leoA:undetectable","1ruaH-3leoA:21.33;1ruaL-3leoA:16.44"],["4ZN7_A_DESA601_1","ESTROGEN RECEPTOR","3leo","LEUKOTRIENE C4 SYNTHASE","Homo sapiens",5,"LEU A  81;ALA A  79;LEU A   8;LEU A   7;LEU A 118","PAM A 215 ( 4.5A);None;None;PAM A 215 ( 4.1A);None","1.13A","4zn7A-3leoA:undetectable","4zn7A-3leoA:21.69"]]