SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3let'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		3 / 3 GLU A 139
ALA A 141
SER A  96
 None
 0.60A 1errB-3letA:
undetectable		 1errB-3letA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		4 / 4 SER A 311
LEU A 167
TYR A 298
GLY A 314
 None
 1.50A 1liiA-3letA:
undetectable		 1liiA-3letA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		3 / 3 PHE A 104
LEU A 137
MET A 142
 None
 0.62A 1mx1D-3letA:
3.3		 1mx1D-3letA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 345
HIS A 321
GLY A 343
HIS A 339
GLY A 213
 None
 1.07A 1zz1C-3letA:
undetectable		 1zz1C-3letA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		5 / 11 LEU A 137
GLY A 176
ALA A 182
LEU A 116
SER A  96
 None
 1.15A 2bxgA-3letA:
undetectable		 2bxgA-3letA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		5 / 11 LEU A 137
GLY A 177
ALA A 182
LEU A 116
SER A  96
 None
 1.22A 2bxgA-3letA:
undetectable		 2bxgA-3letA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		4 / 7 GLY A 178
GLY A 177
ALA A 180
ALA A 181
 None
 0.65A 2ha4B-3letA:
2.8		 2ha4B-3letA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		5 / 12 LEU A 318
ILE A 345
GLY A 343
ALA A 342
LEU A 214
 None
 1.04A 3n8zB-3letA:
undetectable		 3n8zB-3letA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		5 / 11 ASN A 185
ARG A 189
GLN A 183
ALA A 138
GLY A 176
 None
 1.30A 5cp3A-3letA:
undetectable
5cp3H-3letA:
undetectable		 5cp3A-3letA:
21.14
5cp3H-3letA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		4 / 7 GLY A 152
LYS A 156
ALA A 157
ASP A 161
 None
 0.91A 5mvsA-3letA:
2.0		 5mvsA-3letA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS
(Vibrio
parahaemolyticus) 		4 / 8 GLY A 152
LYS A 156
ALA A 157
ASP A 161
 None
 0.95A 5mvsB-3letA:
undetectable		 5mvsB-3letA:
21.18