SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3lev RNA POLYMERASE SIGMA
FACTOR
(Thermus
aquaticus) 		4 / 7 GLU A 196
GLU A 144
GLU A 140
ARG A 199
 None
 0.91A 4mi4B-3levA:
undetectable
4mi4C-3levA:
undetectable		 4mi4B-3levA:
21.61
4mi4C-3levA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3lev RNA POLYMERASE SIGMA
FACTOR
(Thermus
aquaticus) 		4 / 8 GLU A 196
GLU A 144
GLU A 140
ARG A 199
 None
 0.92A 4mj8B-3levA:
undetectable
4mj8C-3levA:
undetectable		 4mj8B-3levA:
23.79
4mj8C-3levA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3lev RNA POLYMERASE SIGMA
FACTOR
(Thermus
aquaticus) 		3 / 3 LEU A 131
VAL A 174
ASP A 175
 None
 0.60A 4y8wC-3levA:
3.1		 4y8wC-3levA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3lev RNA POLYMERASE SIGMA
FACTOR
(Thermus
aquaticus) 		5 / 12 TYR A 217
LEU A 209
THR A 255
ILE A 258
ILE A 262
 None
 1.06A 5ifuA-3levA:
undetectable		 5ifuA-3levA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3lev RNA POLYMERASE SIGMA
FACTOR
(Thermus
aquaticus) 		4 / 8 VAL A 210
GLN A 229
GLY A 161
LEU A 162
 None
 0.92A 5w3jB-3levA:
undetectable		 5w3jB-3levA:
16.81