SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 8 ALA A 136
LEU A 151
LEU A 150
LEU A 104
 None
 0.89A 1ereE-3lezA:
undetectable		 1ereE-3lezA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 8 ALA A 136
LEU A 151
LEU A 150
LEU A 104
 None
 0.89A 1ereF-3lezA:
undetectable		 1ereF-3lezA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A  85
LYS A  88
ASN A 145
LYS A 247
GLY A 249
ARG A 256
 EPE  A 305 (-3.4A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 (-3.7A)
 0.31A 1ghmA-3lezA:
39.6		 1ghmA-3lezA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A  85
SER A 143
ASN A 145
LYS A 247
GLY A 249
ARG A 256
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 (-3.7A)
 0.59A 1ghmA-3lezA:
39.6		 1ghmA-3lezA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
LYS A  88
ASN A 145
GLU A 179
THR A 229
LYS A 247
GLY A 249
ALA A 250
 EPE  A 305 (-3.4A)
None
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
 0.38A 1i2wA-3lezA:
44.1		 1i2wA-3lezA:
55.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
SER A 143
ASN A 145
THR A 229
LYS A 247
GLY A 249
ALA A 250
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
 0.61A 1i2wA-3lezA:
44.1		 1i2wA-3lezA:
55.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 5 TYR A 118
LEU A 182
THR A 248
ARG A 256
 EPE  A 305 (-3.3A)
None
EPE  A 305 (-3.6A)
EPE  A 305 (-3.7A)
 0.34A 1i2wA-3lezA:
44.1		 1i2wA-3lezA:
55.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		9 / 12 SER A  85
LYS A  88
SER A 143
ASN A 145
GLU A 179
THR A 229
GLY A 249
ALA A 250
ARG A 256
 EPE  A 305 (-3.4A)
None
EPE  A 305 (-2.5A)
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
 0.56A 1i2wB-3lezA:
44.1		 1i2wB-3lezA:
55.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 ALA A  64
ILE A 262
GLY A 260
ILE A 259
ALA A 294
 None
 0.80A 1sguB-3lezA:
undetectable		 1sguB-3lezA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		3 / 3 GLU A 106
GLU A 134
LEU A 151
 None
 0.74A 1v8bA-3lezA:
undetectable		 1v8bA-3lezA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		9 / 12 SER A  85
LYS A  88
ASN A 145
GLU A 179
ASN A 183
THR A 229
LYS A 247
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
None
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.48A 1ymxA-3lezA:
41.6		 1ymxA-3lezA:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
LYS A  88
SER A 143
ASN A 145
GLU A 179
LYS A 247
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 (-2.5A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.63A 1ymxA-3lezA:
41.6		 1ymxA-3lezA:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
LYS A  88
ASN A 145
GLU A 179
ASN A 183
LYS A 247
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
None
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.46A 1ymxB-3lezA:
41.6		 1ymxB-3lezA:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
SER A 143
ASN A 145
GLU A 179
ASN A 183
LYS A 247
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.62A 1ymxB-3lezA:
41.6		 1ymxB-3lezA:
43.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 ALA A  64
GLY A 260
ILE A 259
ALA A 294
VAL A 298
 None
 0.97A 2b7zB-3lezA:
undetectable		 2b7zB-3lezA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 ALA A  64
ILE A 262
GLY A 260
ILE A 259
ALA A 294
 None
 0.81A 2b7zB-3lezA:
undetectable		 2b7zB-3lezA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 11 ALA A 139
LEU A 104
LEU A 132
LEU A 151
ARG A 216
 None
None
None
None
CA  A   3 ( 4.8A)
 0.99A 2ceoA-3lezA:
undetectable		 2ceoA-3lezA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 10 ALA A 139
LEU A 104
LEU A 132
LEU A 151
ARG A 216
 None
None
None
None
CA  A   3 ( 4.8A)
 1.00A 2ceoB-3lezA:
undetectable		 2ceoB-3lezA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 ALA A  64
ILE A 262
GLY A 260
ILE A 259
ALA A 294
 None
 0.83A 2nmzA-3lezA:
undetectable		 2nmzA-3lezA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 10 ALA A 139
LEU A 104
LEU A 132
LEU A 151
ARG A 216
 None
None
None
None
CA  A   3 ( 4.8A)
 1.10A 2xn6A-3lezA:
undetectable
2xn6B-3lezA:
undetectable		 2xn6A-3lezA:
20.17
2xn6B-3lezA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 10 ALA A 139
LEU A 104
LEU A 132
LEU A 151
ARG A 216
 None
None
None
None
CA  A   3 ( 4.8A)
 1.08A 2xn7A-3lezA:
undetectable
2xn7B-3lezA:
undetectable		 2xn7A-3lezA:
20.17
2xn7B-3lezA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 10 ALA A  64
ILE A 262
GLY A 260
ILE A 259
ALA A 294
 None
 0.80A 3ekwA-3lezA:
undetectable		 3ekwA-3lezA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 LEU A 151
ALA A  94
GLY A 157
LEU A  90
ARG A 166
 None
None
CL  A  20 ( 4.3A)
None
None
 1.30A 3gyqA-3lezA:
undetectable
3gyqB-3lezA:
undetectable		 3gyqA-3lezA:
22.30
3gyqB-3lezA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 LYS A  88
TYR A 118
ASN A 145
ASN A 183
THR A 229
LYS A 247
GLY A 249
GLY A 251
 None
EPE  A 305 (-3.3A)
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.60A 3hlwA-3lezA:
41.6		 3hlwA-3lezA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 TYR A 118
SER A 143
ASN A 145
THR A 229
LYS A 247
GLY A 249
GLY A 251
 EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.66A 3hlwA-3lezA:
41.6		 3hlwA-3lezA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 TYR A 118
ASN A 145
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.3A)
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.56A 3hlwB-3lezA:
41.5		 3hlwB-3lezA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 TYR A 118
SER A 143
ASN A 145
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.64A 3hlwB-3lezA:
41.5		 3hlwB-3lezA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 LYS A  88
ASN A 145
ASN A 183
LYS A 247
THR A 248
GLY A 249
GLY A 251
 None
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.37A 3huoA-3lezA:
41.5		 3huoA-3lezA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 LYS A  88
ASN A 145
ASN A 183
LYS A 247
GLY A 249
GLY A 251
 None
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.37A 3huoB-3lezA:
41.6		 3huoB-3lezA:
43.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 10 THR A 146
GLY A 148
LEU A 150
LEU A 151
ILE A 135
 None
 1.14A 3kvrA-3lezA:
undetectable		 3kvrA-3lezA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 7 TYR A 206
LEU A 165
ASP A 170
SER A 194
 None
 1.37A 3lslA-3lezA:
undetectable
3lslD-3lezA:
undetectable		 3lslA-3lezA:
22.18
3lslD-3lezA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 7 SER A 194
TYR A 206
LEU A 165
ASP A 170
 None
 1.34A 3lslA-3lezA:
undetectable
3lslD-3lezA:
undetectable		 3lslA-3lezA:
22.18
3lslD-3lezA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A  85
LYS A  88
ASN A 145
THR A 248
GLY A 249
ARG A 256
 EPE  A 305 (-3.4A)
None
None
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
EPE  A 305 (-3.7A)
 0.98A 3mzeA-3lezA:
20.5		 3mzeA-3lezA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 5 ARG A 166
ASP A 176
ASP A 192
ARG A  80
 None
CA  A   1 ( 2.8A)
None
None
 1.41A 3naiA-3lezA:
undetectable		 3naiA-3lezA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 9 THR A 146
GLY A 148
LEU A 150
LEU A 151
ILE A 135
 None
 1.15A 3nbqA-3lezA:
undetectable		 3nbqA-3lezA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
SER A 143
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.42A 3ny4A-3lezA:
40.2		 3ny4A-3lezA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 8 LEU A 208
ARG A 217
THR A 221
TRP A 263
 None
 0.76A 3ny4A-3lezA:
40.2		 3ny4A-3lezA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 8 LEU A 208
ARG A 217
TRP A 263
PRO A 270
 None
 0.70A 3ny4A-3lezA:
40.2		 3ny4A-3lezA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 LYS A  88
ASN A 145
ASN A 183
LYS A 247
GLY A 249
GLY A 251
 None
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.36A 3q07A-3lezA:
41.7		 3q07A-3lezA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A 143
ASN A 145
ASN A 183
LYS A 247
GLY A 249
GLY A 251
 EPE  A 305 (-2.5A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.58A 3q07A-3lezA:
41.7		 3q07A-3lezA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 LYS A  88
SER A 143
ASN A 145
ASN A 183
LYS A 247
GLY A 249
GLY A 251
 None
EPE  A 305 (-2.5A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.58A 3q07B-3lezA:
41.7		 3q07B-3lezA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		9 / 12 SER A  85
TYR A 118
SER A 143
ASN A 145
LYS A 247
THR A 248
GLY A 249
ALA A 250
ARG A 256
 EPE  A 305 (-3.4A)
EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
 0.47A 3sh8A-3lezA:
42.5		 3sh8A-3lezA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
LYS A  88
ASN A 145
LYS A 247
GLY A 249
ALA A 250
ARG A 256
TYR A 286
 EPE  A 305 (-3.4A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
None
 0.32A 3sh8B-3lezA:
42.1		 3sh8B-3lezA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
SER A 143
ASN A 145
LYS A 247
GLY A 249
ALA A 250
ARG A 256
TYR A 286
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
None
 0.53A 3sh8B-3lezA:
42.1		 3sh8B-3lezA:
56.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 ALA A  64
ASP A  66
ILE A 262
GLY A 260
ILE A 259
VAL A 298
 None
 1.29A 3so9B-3lezA:
undetectable		 3so9B-3lezA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 10 ALA A  64
ASP A  66
ILE A 262
GLY A 260
ILE A 259
ALA A 294
VAL A 298
 None
 1.22A 3t3cB-3lezA:
undetectable		 3t3cB-3lezA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 5 LEU A 165
ALA A  91
MET A 199
THR A 202
 None
 1.33A 3vasB-3lezA:
undetectable		 3vasB-3lezA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 LYS A  88
ASN A 145
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
 None
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
 0.38A 4euzA-3lezA:
40.5		 4euzA-3lezA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A 143
ASN A 145
THR A 229
LYS A 247
THR A 248
GLY A 249
 EPE  A 305 (-2.5A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
 0.66A 4euzA-3lezA:
40.5		 4euzA-3lezA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 10 TYR A 118
SER A 143
ASN A 145
LYS A 247
THR A 248
GLY A 249
ALA A 250
ARG A 256
 EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
 0.36A 4fh2A-3lezA:
35.1		 4fh2A-3lezA:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		10 / 12 SER A  85
TYR A 118
SER A 143
ASN A 145
ASN A 183
LYS A 247
THR A 248
GLY A 249
ALA A 250
ARG A 256
 EPE  A 305 (-3.4A)
EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
 0.50A 4n9kA-3lezA:
44.0		 4n9kA-3lezA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		10 / 12 SER A  85
SER A 143
ASN A 145
ASN A 183
LYS A 247
THR A 248
GLY A 249
ALA A 250
ARG A 256
TYR A 286
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
None
 0.45A 4n9kB-3lezA:
44.1		 4n9kB-3lezA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		9 / 12 TYR A 118
SER A 143
ASN A 145
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.37A 4pm5A-3lezA:
41.4		 4pm5A-3lezA:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		10 / 12 LYS A  88
TYR A 118
SER A 143
ASN A 145
ASN A 183
THR A 229
LYS A 247
GLY A 249
ALA A 250
GLY A 251
 None
EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
None
 0.42A 4pm7A-3lezA:
41.4		 4pm7A-3lezA:
43.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		10 / 12 TYR A 118
SER A 143
ASN A 145
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
ALA A 250
GLY A 251
 EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
None
 0.37A 4pm9A-3lezA:
41.4		 4pm9A-3lezA:
44.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.13A 4qvpH-3lezA:
undetectable
4qvpI-3lezA:
undetectable		 4qvpH-3lezA:
24.65
4qvpI-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.13A 4qvpV-3lezA:
undetectable
4qvpW-3lezA:
undetectable		 4qvpV-3lezA:
24.65
4qvpW-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 11 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.17A 4qvvV-3lezA:
undetectable		 4qvvV-3lezA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 11 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.17A 4qw0H-3lezA:
undetectable
4qw0I-3lezA:
undetectable		 4qw0H-3lezA:
24.65
4qw0I-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 11 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.17A 4qw0V-3lezA:
undetectable
4qw0W-3lezA:
undetectable		 4qw0V-3lezA:
24.65
4qw0W-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.13A 4qw1H-3lezA:
undetectable
4qw1I-3lezA:
undetectable		 4qw1H-3lezA:
24.65
4qw1I-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.13A 4qw1V-3lezA:
undetectable
4qw1W-3lezA:
undetectable		 4qw1V-3lezA:
24.65
4qw1W-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 8 ALA A  64
LEU A  49
ALA A 294
LEU A  60
ALA A 274
 None
 0.86A 4z90A-3lezA:
undetectable
4z90B-3lezA:
undetectable
4z90C-3lezA:
undetectable
4z90D-3lezA:
undetectable
4z90E-3lezA:
undetectable		 4z90A-3lezA:
20.86
4z90B-3lezA:
20.86
4z90C-3lezA:
20.86
4z90D-3lezA:
20.86
4z90E-3lezA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 7 LEU A  60
ALA A 274
ALA A  64
LEU A  49
ALA A 294
 None
 0.90A 4z90F-3lezA:
undetectable
4z90G-3lezA:
undetectable
4z90H-3lezA:
undetectable
4z90J-3lezA:
undetectable		 4z90F-3lezA:
20.86
4z90G-3lezA:
20.86
4z90H-3lezA:
20.86
4z90J-3lezA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 7 ASP A 258
ILE A 234
GLY A 245
THR A 248
 None
None
None
EPE  A 305 (-3.6A)
 1.11A 4zxiA-3lezA:
undetectable		 4zxiA-3lezA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.15A 5cz7V-3lezA:
undetectable
5cz7W-3lezA:
undetectable		 5cz7V-3lezA:
24.65
5cz7W-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		3 / 3 ASP A 246
ASN A 257
PHE A  87
 None
 0.69A 5dsgB-3lezA:
undetectable		 5dsgB-3lezA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 8 ILE A 262
ALA A 294
THR A 295
VAL A 298
 None
 0.82A 5ecnD-3lezA:
undetectable		 5ecnD-3lezA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 11 THR A  86
PRO A  89
ALA A 139
ILE A 140
PRO A 120
 None
 1.26A 5ewjA-3lezA:
undetectable
5ewjB-3lezA:
undetectable		 5ewjA-3lezA:
22.44
5ewjB-3lezA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 THR A  86
PRO A  89
ALA A 139
ILE A 140
PRO A 120
 None
 1.27A 5ewjC-3lezA:
undetectable
5ewjD-3lezA:
undetectable		 5ewjC-3lezA:
22.44
5ewjD-3lezA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		9 / 12 SER A  85
SER A 143
ASN A 145
ASN A 183
LYS A 247
GLY A 249
ALA A 250
ARG A 256
TYR A 286
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
None
 0.52A 5ghyA-3lezA:
44.1		 5ghyA-3lezA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		9 / 12 SER A  85
SER A 143
ASN A 145
ASN A 183
LYS A 247
GLY A 249
ALA A 250
ARG A 256
TYR A 286
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
None
 0.50A 5ghyB-3lezA:
44.0		 5ghyB-3lezA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		10 / 11 SER A  85
TYR A 118
SER A 143
ASN A 145
ASN A 183
LYS A 247
THR A 248
GLY A 249
ALA A 250
ARG A 256
 EPE  A 305 (-3.4A)
EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
EPE  A 305 (-3.7A)
 0.47A 5ghzA-3lezA:
44.2		 5ghzA-3lezA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		9 / 10 SER A  85
TYR A 118
SER A 143
ASN A 145
ASN A 183
LYS A 247
THR A 248
GLY A 249
ARG A 256
 EPE  A 305 (-3.4A)
EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
EPE  A 305 (-3.7A)
 0.51A 5ghzB-3lezA:
44.1		 5ghzB-3lezA:
56.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.17A 5l5fH-3lezA:
undetectable
5l5fI-3lezA:
undetectable		 5l5fH-3lezA:
24.65
5l5fI-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.17A 5l5fV-3lezA:
undetectable
5l5fW-3lezA:
undetectable		 5l5fV-3lezA:
24.65
5l5fW-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.19A 5l5zH-3lezA:
undetectable
5l5zI-3lezA:
undetectable		 5l5zH-3lezA:
24.65
5l5zI-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		5 / 12 SER A 278
ALA A 250
GLY A 251
ALA A  82
THR A  84
 None
EPE  A 305 ( 4.1A)
None
None
None
 1.18A 5l5zV-3lezA:
undetectable
5l5zW-3lezA:
undetectable		 5l5zV-3lezA:
24.65
5l5zW-3lezA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		4 / 7 LEU A  90
ARG A 217
THR A 221
LEU A 224
 None
 0.95A 5zcpA-3lezA:
undetectable
5zcpJ-3lezA:
undetectable		 5zcpA-3lezA:
18.13
5zcpJ-3lezA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.46A 6b5yB-3lezA:
40.6		 6b5yB-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
SER A 143
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.70A 6b5yB-3lezA:
40.6		 6b5yB-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.50A 6b5yD-3lezA:
40.7		 6b5yD-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
SER A 143
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.73A 6b5yD-3lezA:
40.7		 6b5yD-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
SER A 143
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.60A 6b68B-3lezA:
40.8		 6b68B-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A  85
ASN A 183
THR A 229
LYS A 247
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.41A 6b68D-3lezA:
40.7		 6b68D-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.39A 6b69A-3lezA:
40.7
6b69B-3lezA:
40.7		 6b69A-3lezA:
18.97
6b69B-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
SER A 143
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.65A 6b69A-3lezA:
40.7
6b69B-3lezA:
40.7		 6b69A-3lezA:
18.97
6b69B-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.39A 6b69D-3lezA:
40.6		 6b69D-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A  85
SER A 143
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.63A 6b69D-3lezA:
40.6		 6b69D-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.39A 6b6aB-3lezA:
40.7		 6b6aB-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 SER A  85
SER A 143
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.64A 6b6aB-3lezA:
40.7		 6b6aB-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A  85
ASN A 183
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.27A 6b6aD-3lezA:
40.6		 6b6aD-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A  85
SER A 143
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.61A 6b6aD-3lezA:
40.6		 6b6aD-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A  85
ASN A 183
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.36A 6b6cA-3lezA:
40.4		 6b6cA-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
SER A 143
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.40A 6b6dA-3lezA:
40.2		 6b6dA-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		8 / 12 SER A  85
SER A 143
ASN A 183
THR A 229
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.61A 6b6eA-3lezA:
40.5		 6b6eA-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		6 / 12 SER A  85
ASN A 183
LYS A 247
THR A 248
GLY A 249
GLY A 251
 EPE  A 305 (-3.4A)
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.6A)
EPE  A 305 (-3.4A)
None
 0.38A 6b6fA-3lezA:
40.2		 6b6fA-3lezA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 TYR A 118
ASN A 145
ASN A 183
THR A 229
LYS A 247
GLY A 249
GLY A 251
 EPE  A 305 (-3.3A)
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.47A 6c79A-3lezA:
41.4		 6c79A-3lezA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 3lez BETA-LACTAMASE
(Oceanobacillus
iheyensis) 		7 / 12 TYR A 118
SER A 143
ASN A 145
THR A 229
LYS A 247
GLY A 249
GLY A 251
 EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
None
 0.62A 6c79A-3lezA:
41.4		 6c79A-3lezA:
13.31