SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL B 105
GLY B 126
LEU A  54
 None
 1.34A 1fkpA-3lf4A:
undetectable		 1fkpA-3lf4A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL B 105
GLY B 126
LEU A  54
 None
 1.39A 1lw0A-3lf4A:
undetectable		 1lw0A-3lf4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL B 105
GLY B 126
LEU A  54
 None
 1.38A 1lwcA-3lf4A:
undetectable		 1lwcA-3lf4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.) 		5 / 9 LEU A  61
VAL A  22
VAL B 105
GLY B 126
LEU A  54
 None
 1.37A 1vrtA-3lf4A:
undetectable		 1vrtA-3lf4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.) 		3 / 3 LEU A  54
PHE A  27
ARG B  95
 None
None
0YG  B  67 ( 3.0A)
 0.82A 1xdkB-3lf4A:
undetectable		 1xdkB-3lf4A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.) 		4 / 5 VAL B 122
ILE A  29
MET B 136
ARG B  70
 None
None
None
0YG  B  67 ( 4.0A)
 1.45A 3oezA-3lf4B:
undetectable		 3oezA-3lf4B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL B 105
GLY B 126
LEU A  54
 None
 1.40A 3qipA-3lf4A:
undetectable		 3qipA-3lf4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.;
Discosoma
sp.) 		5 / 12 PHE A  56
GLN B 213
LEU A  46
VAL A  48
ILE A  29
 None
LEN  A  66 (-4.5A)
None
None
None
 1.20A 4k38B-3lf4A:
undetectable		 4k38B-3lf4A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL B 105
GLY B 126
LEU A  54
 None
 1.37A 5hbmA-3lf4A:
undetectable		 5hbmA-3lf4A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102
FLUORESCENT TIMER
PRECURSOR BLUE102
(Discosoma
sp.;
Discosoma
sp.) 		4 / 9 PHE A  65
VAL A  16
HIS A  17
SER B  86
 None
 0.94A 6c2mD-3lf4A:
undetectable		 6c2mD-3lf4A:
22.35