SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lfl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		5 / 12 MET A 205
GLU A 154
LEU A 153
ILE A 172
GLY A 165
 None
 1.21A 1g50B-3lflA:
undetectable		 1g50B-3lflA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		4 / 8 GLY A 165
PHE A 180
ILE A 172
SER A 170
 None
 0.99A 2a8tB-3lflA:
undetectable		 2a8tB-3lflA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		4 / 5 LEU A  56
ALA A 235
PHE A 224
ASN A 231
 GSH  A 241 (-3.7A)
None
None
None
 1.36A 3uq6A-3lflA:
undetectable		 3uq6A-3lflA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		4 / 4 LEU A  56
ALA A 235
PHE A 224
ASN A 231
 GSH  A 241 (-3.7A)
None
None
None
 1.39A 3vaqA-3lflA:
undetectable		 3vaqA-3lflA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		4 / 4 LEU A  56
ALA A 235
PHE A 224
ASN A 231
 GSH  A 241 (-3.7A)
None
None
None
 1.38A 3vasA-3lflA:
undetectable		 3vasA-3lflA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		6 / 6 PHE A  34
ARG A  37
LEU A  71
PRO A  73
GLU A  85
SER A  86
 GSH  A 241 (-3.6A)
None
GSH  A 241 (-3.6A)
GSH  A 241 (-4.5A)
GSH  A 241 (-3.0A)
GSH  A 241 (-2.5A)
 0.31A 3vlnA-3lflA:
36.9		 3vlnA-3lflA:
99.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		3 / 3 LYS A  45
ILE A  47
ILE A  24
 None
 0.68A 4y0qA-3lflA:
undetectable		 4y0qA-3lflA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		3 / 3 LEU A 200
VAL A 192
ASP A 193
 None
 0.62A 4y8wC-3lflA:
undetectable		 4y8wC-3lflA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		4 / 6 GLU A  91
LEU A 103
GLN A 113
LYS A 114
 None
 0.89A 5yvnA-3lflA:
36.7		 5yvnA-3lflA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		5 / 6 LEU A 103
GLN A 113
LYS A 114
LEU A 117
LEU A 175
 None
 0.43A 5yvnA-3lflA:
36.7		 5yvnA-3lflA:
99.59