SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 LEU A 106
VAL A 298
LEU A 299
LEU A 132
LEU A 125
 None
 1.02A 1mx1A-3lftA:
2.4		 1mx1A-3lftA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A 137
GLY A 292
VAL A 289
GLY A 288
VAL A 115
 None
 1.16A 3f8wA-3lftA:
undetectable		 3f8wA-3lftA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A 137
GLY A 292
VAL A 289
GLY A 288
VAL A 115
 None
 1.17A 3f8wC-3lftA:
undetectable		 3f8wC-3lftA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 287
THR A 291
ASP A 163
ASN A 244
GLY A 116
 None
None
TRP  A   1 (-2.5A)
TRP  A   1 (-3.3A)
None
 1.33A 3g1uA-3lftA:
undetectable		 3g1uA-3lftA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 VAL A 235
ILE A 264
VAL A 240
GLY A 185
 None
 0.78A 3hjoB-3lftA:
undetectable		 3hjoB-3lftA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 ILE A 282
PRO A 166
SER A 317
LYS A 316
GLY A 315
 None
 1.33A 3ik6B-3lftA:
3.1
3ik6E-3lftA:
2.6		 3ik6B-3lftA:
24.92
3ik6E-3lftA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ILE A 282
PRO A 166
SER A 317
LYS A 316
GLY A 315
 None
 1.34A 3iluB-3lftA:
undetectable
3iluE-3lftA:
3.6		 3iluB-3lftA:
24.92
3iluE-3lftA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 5 ILE A 282
PRO A 166
SER A 317
LYS A 316
GLY A 315
 None
 1.32A 3tkdB-3lftA:
undetectable		 3tkdB-3lftA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 5 ILE A 282
PRO A 166
SER A 317
LYS A 316
GLY A 315
 None
 1.30A 3tkdA-3lftA:
3.5		 3tkdA-3lftA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 ASP A 112
VAL A 114
GLY A 110
ALA A 108
THR A 129
 None
 1.21A 3ucjA-3lftA:
undetectable		 3ucjA-3lftA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 ASP A 112
VAL A 114
GLY A 110
ALA A 108
THR A 129
 None
 1.20A 3ucjB-3lftA:
3.6		 3ucjB-3lftA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 THR A 119
ASN A 194
ASP A 141
ILE A 143
 TRP  A   1 (-3.7A)
TRP  A   1 (-3.5A)
None
None
 1.49A 3w9tB-3lftA:
undetectable		 3w9tB-3lftA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 LEU A  66
SER A  63
ASP A 163
ASP A 141
 None
TRP  A   1 (-3.4A)
TRP  A   1 (-2.5A)
None
 1.31A 4qtuD-3lftA:
3.9		 4qtuD-3lftA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 VAL A 228
THR A 221
ASN A 222
ILE A 246
ASP A 243
 None
 1.47A 4xe0A-3lftA:
undetectable		 4xe0A-3lftA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LEU A  56
PHE A  89
ILE A 117
 None
 0.72A 5dzk1-3lftA:
undetectable
5dzkF-3lftA:
undetectable
5dzkM-3lftA:
undetectable		 5dzk1-3lftA:
12.50
5dzkF-3lftA:
22.22
5dzkM-3lftA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A 117
GLY A  70
ILE A 242
ALA A 268
ASP A  65
 None
None
TRP  A   1 (-4.3A)
TRP  A   1 ( 3.9A)
None
 1.07A 5e72A-3lftA:
undetectable		 5e72A-3lftA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A 122
THR A 119
ALA A 118
ALA A 121
GLY A 160
 None
TRP  A   1 (-3.7A)
TRP  A   1 (-3.4A)
None
None
 1.10A 5l5zK-3lftA:
undetectable
5l5zL-3lftA:
undetectable		 5l5zK-3lftA:
20.13
5l5zL-3lftA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A 122
THR A 119
ALA A 118
ALA A 121
GLY A 160
 None
TRP  A   1 (-3.7A)
TRP  A   1 (-3.4A)
None
None
 1.10A 5l5zY-3lftA:
undetectable
5l5zZ-3lftA:
undetectable		 5l5zY-3lftA:
20.13
5l5zZ-3lftA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 LEU A  56
VAL A 115
LEU A  64
ILE A  71
 None
 1.00A 5v0vA-3lftA:
undetectable		 5v0vA-3lftA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A 128
SER A 127
VAL A  99
SER A 103
GLY A 116
 None
 1.04A 6bklA-3lftA:
undetectable
6bklB-3lftA:
undetectable
6bklC-3lftA:
undetectable
6bklD-3lftA:
undetectable		 6bklA-3lftA:
7.54
6bklB-3lftA:
7.54
6bklC-3lftA:
7.54
6bklD-3lftA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3lft UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 260
SER A 259
ALA A 225
 None
 0.62A 6dwnC-3lftA:
undetectable		 6dwnC-3lftA:
15.49