SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.05A 1cqeA-3lfuA:
undetectable		 1cqeA-3lfuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.05A 1cqeB-3lfuA:
undetectable		 1cqeB-3lfuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 7 PHE A 222
PHE A 267
PHE A 271
VAL A 219
 None
 1.00A 1lh6A-3lfuA:
undetectable		 1lh6A-3lfuA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 5 LEU A 559
GLY A 602
ILE A 572
PHE A 632
 None
 0.92A 1xf1A-3lfuA:
undetectable		 1xf1A-3lfuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 6 LEU A 559
GLY A 602
ILE A 572
PHE A 632
 None
 0.86A 1xf1B-3lfuA:
undetectable		 1xf1B-3lfuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.06A 2aylA-3lfuA:
undetectable		 2aylA-3lfuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.06A 2aylB-3lfuA:
undetectable		 2aylB-3lfuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 5 LEU A 512
GLN A 480
THR A 481
HIS A 537
 None
 1.22A 2zj0B-3lfuA:
undetectable		 2zj0B-3lfuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 5 LEU A 512
GLN A 480
THR A 481
HIS A 537
 None
 1.33A 3ce6B-3lfuA:
undetectable		 3ce6B-3lfuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 9 LEU A 304
GLU A 298
TYR A 600
LEU A  28
ASP A 248
 None
 1.48A 3hthB-3lfuA:
0.0		 3hthB-3lfuA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 5 LEU A 512
GLN A 480
THR A 481
HIS A 537
 None
 1.39A 3n58C-3lfuA:
undetectable		 3n58C-3lfuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.01A 3n8wA-3lfuA:
undetectable		 3n8wA-3lfuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.04A 3n8zA-3lfuA:
undetectable		 3n8zA-3lfuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.01A 3n8zB-3lfuA:
undetectable		 3n8zB-3lfuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 10 ILE A 297
TYR A 600
LEU A 308
ILE A 318
ILE A 572
 None
 1.04A 3prsA-3lfuA:
undetectable		 3prsA-3lfuA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 8 LEU A 308
ALA A  31
SER A 285
TYR A 600
 None
SO4  A1000 (-3.3A)
None
None
 0.96A 3rodA-3lfuA:
3.0		 3rodA-3lfuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 8 ARG A 140
GLY A 489
GLY A 502
ASN A 508
 None
 0.68A 3v3nB-3lfuA:
undetectable		 3v3nB-3lfuA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 8 ARG A 140
GLY A 489
GLY A 502
ASN A 508
 None
 0.67A 3v3nC-3lfuA:
undetectable		 3v3nC-3lfuA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		3 / 3 PHE A 111
ASP A 182
ARG A 195
 None
 0.81A 4eahF-3lfuA:
undetectable		 4eahF-3lfuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		3 / 3 PHE A 111
ASP A 182
ARG A 195
 None
 0.81A 4eahG-3lfuA:
undetectable		 4eahG-3lfuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 ILE A 297
ALA A 599
LEU A 636
ILE A 289
ASN A 288
 None
 1.38A 4gh8B-3lfuA:
undetectable		 4gh8B-3lfuA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 7 ASN A 282
SER A 285
VAL A 603
ARG A 605
 None
None
None
SO4  A1000 (-2.8A)
 1.13A 4ijiH-3lfuA:
undetectable		 4ijiH-3lfuA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 6 ASP A 328
ASN A 325
ALA A 615
TYR A 614
 None
 1.09A 4mdaA-3lfuA:
undetectable		 4mdaA-3lfuA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.19A 4rrwB-3lfuA:
undetectable		 4rrwB-3lfuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.19A 4rrzB-3lfuA:
undetectable		 4rrzB-3lfuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 9 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.09A 4rs0A-3lfuA:
undetectable		 4rs0A-3lfuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 9 LEU A 444
ASP A 424
LEU A 450
LEU A 458
ALA A 454
 None
 1.08A 5dqfA-3lfuA:
undetectable		 5dqfA-3lfuA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.13A 5ikrA-3lfuA:
undetectable		 5ikrA-3lfuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lfu DNA HELICASE II
(Escherichia
coli) 		6 / 12 VAL A  38
LEU A  39
ALA A  66
GLY A 247
ALA A  29
LEU A 279
 None
 1.10A 5kirA-3lfuA:
undetectable		 5kirA-3lfuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 7 LEU A 114
ASP A 188
ALA A 190
LEU A 193
 None
 0.89A 5nwvA-3lfuA:
undetectable		 5nwvA-3lfuA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3lfu DNA HELICASE II
(Escherichia
coli) 		5 / 12 TYR A 254
ILE A 253
LEU A 598
ALA A 562
LEU A 353
 None
 1.44A 5zwrB-3lfuA:
undetectable		 5zwrB-3lfuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3lfu DNA HELICASE II
(Escherichia
coli) 		4 / 8 ASP A 270
TYR A 230
GLY A 258
VAL A 261
 None
 1.02A 6giqL-3lfuA:
undetectable
6giqP-3lfuA:
undetectable
6giqT-3lfuA:
undetectable		 6giqL-3lfuA:
22.64
6giqP-3lfuA:
14.72
6giqT-3lfuA:
8.50