SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 LEU A 223
PHE A 188
VAL A 190
VAL A 281
 None
 0.76A 1epbB-3lfvA:
undetectable		 1epbB-3lfvA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 11 VAL A 279
GLY A 280
LEU A 189
GLY A 311
GLU A 321
 None
 1.18A 1iolA-3lfvA:
undetectable		 1iolA-3lfvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 ILE A 371
GLY A 500
ILE A 350
VAL A 464
PHE A 380
 None
 1.14A 1sg9A-3lfvA:
undetectable		 1sg9A-3lfvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 LEU A 155
LEU A 152
GLN A 148
LEU A 179
LEU A 174
 None
 1.25A 1zucB-3lfvA:
undetectable		 1zucB-3lfvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 10 GLU A 374
ILE A 503
GLY A 500
CYH A 499
LEU A 492
 None
 1.48A 3adsA-3lfvA:
undetectable		 3adsA-3lfvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 GLN A 490
LEU A 492
GLU A 489
LEU A 452
 None
 0.77A 3h5gA-3lfvA:
undetectable
3h5gC-3lfvA:
undetectable		 3h5gA-3lfvA:
6.52
3h5gC-3lfvA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 PHE A 498
GLN A 504
PHE A 124
 None
 0.81A 3rv5A-3lfvA:
undetectable		 3rv5A-3lfvA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ARG A 432
PHE A 433
PRO A 434
 None
 0.54A 3zoaB-3lfvA:
undetectable		 3zoaB-3lfvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 PHE A 361
ASP A 335
LEU A 336
HIS A  93
 None
 1.32A 4paeA-3lfvA:
undetectable		 4paeA-3lfvA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 GLU A 348
CYH A 367
LEU A 492
ILE A 354
 None
 0.94A 4xumA-3lfvA:
undetectable		 4xumA-3lfvA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 PHE A 341
LEU A 333
ALA A 337
ILE A 465
ILE A 497
 None
 1.20A 5hbsA-3lfvA:
undetectable		 5hbsA-3lfvA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 ASP A 107
ASN A 330
ASN A 487
GLN A 490
 None
 1.20A 5l6eA-3lfvA:
undetectable		 5l6eA-3lfvA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 HIS A  93
SER A  96
LYS A 100
 None
 1.37A 5os7A-3lfvA:
undetectable		 5os7A-3lfvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 10 PRO A 270
ILE A 266
VAL A 233
LEU A 236
ASP A 248
 None
 1.26A 5tixB-3lfvA:
undetectable		 5tixB-3lfvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 HIS A  93
SER A  96
LYS A 100
 None
 1.37A 6gmdB-3lfvA:
undetectable		 6gmdB-3lfvA:
21.68