SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lg0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 4 HIS A 250
LEU A 389
LEU A 310
LEU A 100
 None
 1.14A 1a4lD-3lg0A:
undetectable		 1a4lD-3lg0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 198
ILE A 140
ILE A 209
ALA A 206
ASN A 145
 None
 1.25A 1jtxA-3lg0A:
undetectable		 1jtxA-3lg0A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 11 LEU A 260
PHE A 101
GLY A 238
LEU A 389
LEU A 264
 None
 1.05A 1mx1A-3lg0A:
undetectable		 1mx1A-3lg0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 8 VAL A 340
ASP A 411
ASP A 412
LEU A 330
 None
 1.16A 1pk2A-3lg0A:
undetectable		 1pk2A-3lg0A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 ALA A 300
ALA A 299
LEU A 298
ILE A  80
LEU A  90
 None
 0.89A 2aclG-3lg0A:
undetectable		 2aclG-3lg0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 ARG A 241
VAL A 383
THR A 375
 None
 0.81A 2nmzA-3lg0A:
undetectable		 2nmzA-3lg0A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 LEU A 122
THR A 118
LEU A 259
ASP A 256
 None
 1.09A 2wm3A-3lg0A:
3.1		 2wm3A-3lg0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 11 THR A 386
THR A 382
LEU A 349
GLY A 204
VAL A 378
 None
 1.16A 3lxiB-3lg0A:
undetectable		 3lxiB-3lg0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 11 GLY A 345
LEU A 385
LEU A 348
LEU A 330
LEU A 327
 None
 0.86A 3ndvA-3lg0A:
undetectable
3ndvB-3lg0A:
undetectable		 3ndvA-3lg0A:
21.03
3ndvB-3lg0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 11 LEU A 330
LEU A 327
GLY A 345
LEU A 385
LEU A 348
 None
 0.87A 3ndvA-3lg0A:
undetectable
3ndvB-3lg0A:
undetectable		 3ndvA-3lg0A:
21.03
3ndvB-3lg0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 11 GLY A 345
LEU A 385
LEU A 348
LEU A 330
LEU A 327
 None
 0.85A 3ndvC-3lg0A:
undetectable
3ndvD-3lg0A:
undetectable		 3ndvC-3lg0A:
21.03
3ndvD-3lg0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 11 LEU A 330
LEU A 327
GLY A 345
LEU A 385
LEU A 348
 None
 0.87A 3ndvC-3lg0A:
undetectable
3ndvD-3lg0A:
undetectable		 3ndvC-3lg0A:
21.03
3ndvD-3lg0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 8 LEU A 389
THR A 386
VAL A 202
GLY A 347
 None
 0.86A 4eq4B-3lg0A:
undetectable		 4eq4B-3lg0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		6 / 12 LEU A 307
PHE A 101
ASN A  59
GLY A 240
THR A 237
ALA A 232
 None
 1.48A 4nkxB-3lg0A:
undetectable		 4nkxB-3lg0A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 ILE A 133
ASP A 191
ARG A 124
 None
 0.75A 4pstA-3lg0A:
undetectable		 4pstA-3lg0A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		4 / 7 GLU A 200
ARG A 344
GLY A 207
GLY A 204
 None
 0.89A 4rdxA-3lg0A:
undetectable		 4rdxA-3lg0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 11 ASN A  59
LEU A 310
LEU A 307
LEU A 245
GLU A 234
 None
 1.11A 4wg0H-3lg0A:
undetectable
4wg0I-3lg0A:
undetectable
4wg0J-3lg0A:
undetectable		 4wg0H-3lg0A:
2.43
4wg0I-3lg0A:
2.43
4wg0J-3lg0A:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3lg0 ORNITHINE
AMINOTRANSFERASE
(Plasmodium
falciparum) 		5 / 10 LEU A 246
GLU A 234
LEU A 259
PHE A 230
THR A 248
 None
 1.28A 4zmeB-3lg0A:
undetectable		 4zmeB-3lg0A:
20.42