SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		4 / 6 ALA A 297
LYS A 300
ASP A 304
ALA A 305
 None
 0.27A 1iwhA-3lg3A:
undetectable		 1iwhA-3lg3A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		4 / 5 ARG A 218
LEU A 314
ASP A 285
LEU A 229
 None
 1.28A 1n13B-3lg3A:
undetectable
1n13C-3lg3A:
undetectable		 1n13B-3lg3A:
13.75
1n13C-3lg3A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		4 / 4 HIS A 185
VAL A 156
THR A 352
LEU A  70
 None
 1.16A 1oq5A-3lg3A:
undetectable		 1oq5A-3lg3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		5 / 11 TYR A 283
SER A  29
ILE A 211
VAL A 215
ALA A 216
 None
 1.03A 1uduA-3lg3A:
undetectable		 1uduA-3lg3A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		5 / 10 TYR A 280
ALA A 281
ALA A 232
ALA A 284
TYR A 283
 None
 1.33A 2r2vC-3lg3A:
undetectable
2r2vF-3lg3A:
undetectable
2r2vG-3lg3A:
undetectable		 2r2vC-3lg3A:
6.62
2r2vF-3lg3A:
6.62
2r2vG-3lg3A:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		5 / 10 ALA A 284
LEU A  54
LEU A  58
LEU A 286
LEU A 229
 None
 1.09A 2xn6A-3lg3A:
undetectable
2xn6B-3lg3A:
undetectable		 2xn6A-3lg3A:
20.65
2xn6B-3lg3A:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		5 / 12 LEU A 230
ALA A 210
ALA A 284
VAL A 287
PHE A 302
 None
 1.13A 3b0wB-3lg3A:
undetectable		 3b0wB-3lg3A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		4 / 4 THR A 396
VAL A 404
GLY A  76
THR A  74
 None
 1.03A 3cflA-3lg3A:
undetectable		 3cflA-3lg3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		3 / 3 ASP A 222
ARG A 218
ASP A  32
 None
 0.79A 4fp9C-3lg3A:
undetectable		 4fp9C-3lg3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		3 / 3 ASP A 222
ARG A 218
ASP A  32
 None
 0.81A 4fp9F-3lg3A:
undetectable		 4fp9F-3lg3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		3 / 3 SER A 104
ALA A 100
VAL A  96
 None
 0.54A 4o2bA-3lg3A:
undetectable		 4o2bA-3lg3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		5 / 11 ARG A   5
SER A  29
ASP A  32
LEU A  36
LEU A  12
 None
 1.48A 4or0A-3lg3A:
undetectable		 4or0A-3lg3A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		3 / 3 MET A 199
ASP A 257
PHE A 264
 None
 1.03A 4xeyA-3lg3A:
undetectable		 4xeyA-3lg3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		3 / 3 MET A 199
ASP A 257
PHE A 264
 None
 1.01A 4xeyB-3lg3A:
undetectable		 4xeyB-3lg3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		5 / 8 ALA A 100
VAL A 121
ALA A  97
GLY A  93
MET A  91
 None
 1.39A 4zjzA-3lg3A:
undetectable		 4zjzA-3lg3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		5 / 12 GLY A 183
LEU A 230
LYS A  53
LEU A  54
ALA A 221
 None
 0.84A 5bw4B-3lg3A:
undetectable		 5bw4B-3lg3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		5 / 12 LEU A 172
GLY A 164
ASP A 188
THR A 234
VAL A 184
 None
 1.35A 5d0yA-3lg3A:
undetectable		 5d0yA-3lg3A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		3 / 3 GLU A 160
TRP A  94
ASN A 101
 None
 1.10A 5dv4A-3lg3A:
undetectable		 5dv4A-3lg3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		4 / 6 PHE A 129
ARG A 130
ALA A  78
GLN A 134
 None
 0.85A 6b89B-3lg3A:
undetectable		 6b89B-3lg3A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		4 / 6 PHE A 129
ARG A 131
ALA A  82
GLN A 134
 None
 0.90A 6b89B-3lg3A:
undetectable		 6b89B-3lg3A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3lg3 ISOCITRATE LYASE
(Yersinia
pestis) 		4 / 6 TYR A 280
ASP A 247
GLN A 212
ALA A 236
 None
 1.23A 6djzB-3lg3A:
undetectable		 6djzB-3lg3A:
19.31