SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		6 / 12 LEU A 206
GLY A  75
TYR A  76
TYR A  77
ILE A  88
TYR A  91
 None
 1.11A 1p91B-3lg5A:
undetectable		 1p91B-3lg5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 8 PHE A 165
TYR A  91
TRP A  94
ASP A  99
 None
None
None
MG  A 701 (-2.5A)
 0.91A 1rmtD-3lg5A:
undetectable		 1rmtD-3lg5A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.30A 1v54A-3lg5A:
2.0
1v54C-3lg5A:
undetectable		 1v54A-3lg5A:
21.62
1v54C-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.31A 1v54N-3lg5A:
1.1
1v54P-3lg5A:
1.6		 1v54N-3lg5A:
21.62
1v54P-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.31A 1v55A-3lg5A:
1.1
1v55C-3lg5A:
undetectable		 1v55A-3lg5A:
21.62
1v55C-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 ASP A 103
ARG A 104
ASP A 252
 None
 0.89A 1vptA-3lg5A:
undetectable		 1vptA-3lg5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 THR A 156
GLU A 208
HIS A 164
 None
None
SO4  A 705 (-3.9A)
 0.81A 1xwfA-3lg5A:
undetectable		 1xwfA-3lg5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 THR A 156
GLU A 208
HIS A 164
 None
None
SO4  A 705 (-3.9A)
 0.84A 1xwfB-3lg5A:
undetectable		 1xwfB-3lg5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 THR A 156
GLU A 208
HIS A 164
 None
None
SO4  A 705 (-3.9A)
 0.83A 1xwfC-3lg5A:
undetectable		 1xwfC-3lg5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 THR A 156
GLU A 208
HIS A 164
 None
None
SO4  A 705 (-3.9A)
 0.83A 1xwfD-3lg5A:
undetectable		 1xwfD-3lg5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.31A 2dyrA-3lg5A:
undetectable
2dyrC-3lg5A:
undetectable		 2dyrA-3lg5A:
21.62
2dyrC-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.30A 2dyrN-3lg5A:
undetectable
2dyrP-3lg5A:
1.6		 2dyrN-3lg5A:
21.62
2dyrP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.31A 2eijN-3lg5A:
undetectable
2eijP-3lg5A:
undetectable		 2eijN-3lg5A:
21.62
2eijP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.32A 2eikA-3lg5A:
undetectable
2eikC-3lg5A:
undetectable		 2eikA-3lg5A:
21.62
2eikC-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.30A 2eikN-3lg5A:
undetectable
2eikP-3lg5A:
undetectable		 2eikN-3lg5A:
21.62
2eikP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.31A 2eilA-3lg5A:
1.5
2eilC-3lg5A:
undetectable		 2eilA-3lg5A:
21.62
2eilC-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.30A 2eilN-3lg5A:
1.1
2eilP-3lg5A:
undetectable		 2eilN-3lg5A:
21.62
2eilP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 6 ASP A 205
PHE A 161
THR A 167
TRP A 201
 None
 1.45A 2q6oB-3lg5A:
undetectable		 2q6oB-3lg5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 ALA A 124
ILE A 169
PHE A 165
TYR A 150
THR A 123
 None
 1.22A 2w9sD-3lg5A:
undetectable		 2w9sD-3lg5A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 ALA A 124
ILE A 169
PHE A 165
TYR A 150
THR A 123
 None
 1.20A 2w9sF-3lg5A:
undetectable		 2w9sF-3lg5A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 SER A 343
HIS A 333
ASP A 241
 None
 0.80A 2wa2B-3lg5A:
undetectable		 2wa2B-3lg5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.30A 2y69A-3lg5A:
undetectable
2y69C-3lg5A:
undetectable		 2y69A-3lg5A:
21.62
2y69C-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 GLU A 175
ARG A 194
GLU A 253
TYR A 172
 MG  A 700 ( 3.9A)
POP  A 703 (-2.8A)
MG  A 700 ( 4.9A)
None
 0.97A 2zt7A-3lg5A:
undetectable		 2zt7A-3lg5A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.29A 3abkA-3lg5A:
1.7
3abkC-3lg5A:
undetectable		 3abkA-3lg5A:
21.62
3abkC-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.30A 3abkN-3lg5A:
0.8
3abkP-3lg5A:
undetectable		 3abkN-3lg5A:
21.62
3abkP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.33A 3abmN-3lg5A:
undetectable
3abmP-3lg5A:
undetectable		 3abmN-3lg5A:
21.62
3abmP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.29A 3ag2A-3lg5A:
undetectable
3ag2C-3lg5A:
undetectable		 3ag2A-3lg5A:
21.62
3ag2C-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.31A 3ag2N-3lg5A:
undetectable
3ag2P-3lg5A:
undetectable		 3ag2N-3lg5A:
21.62
3ag2P-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.32A 3ag3N-3lg5A:
undetectable
3ag3P-3lg5A:
undetectable		 3ag3N-3lg5A:
21.62
3ag3P-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.30A 3ag4A-3lg5A:
1.0
3ag4C-3lg5A:
undetectable		 3ag4A-3lg5A:
21.62
3ag4C-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.32A 3ag4N-3lg5A:
1.1
3ag4P-3lg5A:
undetectable		 3ag4N-3lg5A:
21.62
3ag4P-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 139
GLY A 141
ALA A 143
SER A 145
LEU A 149
 None
 0.94A 3hs6A-3lg5A:
undetectable		 3hs6A-3lg5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 11 GLU A 248
LEU A 245
SER A 244
ILE A 249
ASP A  99
 MG  A 702 ( 2.6A)
None
MG  A 702 ( 2.3A)
None
MG  A 701 (-2.5A)
 1.40A 3ko0E-3lg5A:
undetectable
3ko0F-3lg5A:
undetectable
3ko0G-3lg5A:
undetectable
3ko0H-3lg5A:
undetectable		 3ko0E-3lg5A:
12.34
3ko0F-3lg5A:
12.34
3ko0G-3lg5A:
12.34
3ko0H-3lg5A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 SER A 327
SER A 328
HIS A 334
 None
 0.55A 3mzeA-3lg5A:
undetectable		 3mzeA-3lg5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 5 ARG A 179
ASP A  99
ASP A 100
ARG A 104
 None
MG  A 701 (-2.5A)
None
None
 1.42A 3naiA-3lg5A:
0.7		 3naiA-3lg5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 5 HIS A 102
THR A 180
GLU A 253
ASP A 241
 None
None
MG  A 700 ( 4.9A)
None
 1.21A 3tm4A-3lg5A:
undetectable		 3tm4A-3lg5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 5 HIS A 102
THR A 180
GLU A 253
ASP A 241
 None
None
MG  A 700 ( 4.9A)
None
 1.20A 3tm4B-3lg5A:
undetectable		 3tm4B-3lg5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		6 / 12 PHE A 332
SER A  92
ILE A  88
TYR A  77
LEU A  85
LEU A  34
 None
BTM  A 704 (-3.6A)
None
None
None
None
 1.44A 3vn2A-3lg5A:
undetectable		 3vn2A-3lg5A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 264
GLU A 189
ASN A 178
 None
 0.95A 4bupB-3lg5A:
undetectable		 4bupB-3lg5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 193
ALA A 171
GLU A 175
ILE A 202
HIS A 164
 None
None
MG  A 700 ( 3.9A)
None
SO4  A 705 (-3.9A)
 1.23A 4j24D-3lg5A:
undetectable		 4j24D-3lg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 SER A 145
TYR A  91
PRO A 128
 None
 0.95A 4kbeB-3lg5A:
undetectable		 4kbeB-3lg5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 GLU A 234
ARG A 195
HIS A 200
 None
 0.83A 4kf9A-3lg5A:
undetectable		 4kf9A-3lg5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 207
VAL A 319
ALA A 228
SER A 232
LEU A 231
 None
 1.49A 4m11D-3lg5A:
undetectable		 4m11D-3lg5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 LEU A  54
VAL A 139
GLY A 141
ALA A 143
SER A 145
 None
 0.94A 4rrxA-3lg5A:
0.6		 4rrxA-3lg5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 LEU A  54
VAL A 139
GLY A 141
ALA A 143
SER A 145
 None
 0.94A 4rrxB-3lg5A:
0.6		 4rrxB-3lg5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 140
THR A 137
GLY A 129
PRO A 128
ALA A 124
 None
 1.13A 4ypmA-3lg5A:
undetectable		 4ypmA-3lg5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.31A 5b1aN-3lg5A:
undetectable
5b1aP-3lg5A:
1.6		 5b1aN-3lg5A:
21.62
5b1aP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.33A 5b1bN-3lg5A:
undetectable
5b1bP-3lg5A:
1.6		 5b1bN-3lg5A:
21.62
5b1bP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.31A 5b3sN-3lg5A:
undetectable
5b3sP-3lg5A:
1.6		 5b3sN-3lg5A:
21.62
5b3sP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 4 VAL A 276
GLY A 274
ARG A 277
VAL A 280
 None
 1.34A 5d4nA-3lg5A:
undetectable
5d4nB-3lg5A:
undetectable		 5d4nA-3lg5A:
14.40
5d4nB-3lg5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		7 / 9 ASP A  99
ARG A 194
ASN A 240
SER A 244
GLU A 248
ARG A 338
TYR A 339
 MG  A 701 (-2.5A)
POP  A 703 (-2.8A)
MG  A 702 (-2.6A)
MG  A 702 ( 2.3A)
MG  A 702 ( 2.6A)
POP  A 703 (-4.0A)
POP  A 703 ( 4.4A)
 0.72A 5dz2A-3lg5A:
36.0		 5dz2A-3lg5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		7 / 9 ASP A  99
ARG A 194
ASN A 240
SER A 244
GLU A 248
ARG A 338
TYR A 339
 MG  A 701 (-2.5A)
POP  A 703 (-2.8A)
MG  A 702 (-2.6A)
MG  A 702 ( 2.3A)
MG  A 702 ( 2.6A)
POP  A 703 (-4.0A)
POP  A 703 ( 4.4A)
 0.67A 5dz2B-3lg5A:
35.9		 5dz2B-3lg5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		8 / 10 ASP A  99
ARG A 194
ASN A 240
SER A 244
LYS A 247
GLU A 248
ARG A 338
TYR A 339
 MG  A 701 (-2.5A)
POP  A 703 (-2.8A)
MG  A 702 (-2.6A)
MG  A 702 ( 2.3A)
POP  A 703 (-2.8A)
MG  A 702 ( 2.6A)
POP  A 703 (-4.0A)
POP  A 703 ( 4.4A)
 0.57A 5ermA-3lg5A:
6.1		 5ermA-3lg5A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		8 / 9 ASP A  99
ARG A 194
ASN A 240
SER A 244
LYS A 247
GLU A 248
ARG A 338
TYR A 339
 MG  A 701 (-2.5A)
POP  A 703 (-2.8A)
MG  A 702 (-2.6A)
MG  A 702 ( 2.3A)
POP  A 703 (-2.8A)
MG  A 702 ( 2.6A)
POP  A 703 (-4.0A)
POP  A 703 ( 4.4A)
 0.56A 5ermB-3lg5A:
23.1		 5ermB-3lg5A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 LEU A  54
VAL A 139
GLY A 141
ALA A 143
SER A 145
 None
 0.91A 5ikqA-3lg5A:
undetectable		 5ikqA-3lg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 121
LEU A  54
GLY A 141
ALA A 143
SER A 145
 None
 1.12A 5ikqA-3lg5A:
undetectable		 5ikqA-3lg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.29A 5iy5A-3lg5A:
1.2
5iy5C-3lg5A:
1.6		 5iy5A-3lg5A:
21.62
5iy5C-3lg5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 4 LEU A 206
ARG A 160
ILE A 202
PHE A 161
 None
 1.02A 5kirB-3lg5A:
undetectable		 5kirB-3lg5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 PHE A 297
ASP A 299
LEU A 288
 None
 0.70A 5uhcC-3lg5A:
0.4		 5uhcC-3lg5A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 264
GLU A 189
ASN A 178
 None
 0.91A 5wbvA-3lg5A:
undetectable		 5wbvA-3lg5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 HIS A 264
GLU A 189
ASN A 178
 None
 0.92A 5wbvB-3lg5A:
0.6		 5wbvB-3lg5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.33A 5x1fN-3lg5A:
undetectable
5x1fP-3lg5A:
undetectable		 5x1fN-3lg5A:
21.62
5x1fP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.33A 5zcqN-3lg5A:
undetectable
5zcqP-3lg5A:
1.6		 5zcqN-3lg5A:
21.62
5zcqP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 TYR A 172
LEU A 121
ASP A 136
 None
 0.85A 5zv2B-3lg5A:
undetectable		 5zv2B-3lg5A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 193
ALA A 171
GLU A 175
ILE A 202
HIS A 164
 None
None
MG  A 700 ( 3.9A)
None
SO4  A 705 (-3.9A)
 1.24A 6cbzB-3lg5A:
undetectable		 6cbzB-3lg5A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 ARG A 227
LEU A 231
PHE A 235
 None
 0.57A 6nknP-3lg5A:
undetectable		 6nknP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.31A 6nmfN-3lg5A:
0.4
6nmfP-3lg5A:
undetectable		 6nmfN-3lg5A:
21.62
6nmfP-3lg5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 HIS A 102
TRP A  98
THR A 197
TRP A 114
 None
 1.36A 6nmpN-3lg5A:
undetectable
6nmpP-3lg5A:
undetectable		 6nmpN-3lg5A:
21.62
6nmpP-3lg5A:
20.94