SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 5 LEU A 176
VAL A 112
ARG A 109
THR A 175
 None
 1.38A 1nw3A-3lg6A:
undetectable		 1nw3A-3lg6A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 7 VAL A 204
VAL A 157
ALA A 177
LEU A 181
 None
 0.83A 1pthA-3lg6A:
undetectable		 1pthA-3lg6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 7 VAL A 204
VAL A 157
ALA A 177
LEU A 181
 None
 0.83A 1pthB-3lg6A:
undetectable		 1pthB-3lg6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 6 ALA A  91
ILE A  65
VAL A  62
PHE A   6
 None
 0.94A 2cizA-3lg6A:
undetectable		 2cizA-3lg6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		5 / 12 LEU A  82
LEU A  85
ILE A 119
ALA A 177
THR A 175
 None
 1.27A 2v0mC-3lg6A:
undetectable		 2v0mC-3lg6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		5 / 9 TYR A  31
PHE A  24
ALA A  84
LEU A  85
ALA A  23
 None
 1.24A 2vcvH-3lg6A:
16.7		 2vcvH-3lg6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		5 / 9 TYR A  31
PHE A  24
ALA A  84
LEU A  85
ALA A  23
 None
 1.18A 2vcvI-3lg6A:
16.7		 2vcvI-3lg6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 6 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.95A 3abkP-3lg6A:
2.7
3abkW-3lg6A:
undetectable		 3abkP-3lg6A:
20.29
3abkW-3lg6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 7 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.92A 3ag2P-3lg6A:
2.5
3ag2W-3lg6A:
undetectable		 3ag2P-3lg6A:
20.29
3ag2W-3lg6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		5 / 10 SER A  81
LEU A  26
ILE A  22
PRO A 183
GLY A  18
 None
 1.37A 3iluB-3lg6A:
undetectable
3iluE-3lg6A:
undetectable		 3iluB-3lg6A:
21.45
3iluE-3lg6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 6 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.96A 3wg7P-3lg6A:
3.2
3wg7W-3lg6A:
undetectable		 3wg7P-3lg6A:
20.29
3wg7W-3lg6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		3 / 3 LEU A 160
GLU A 162
SER A 164
 None
 0.81A 4ccqA-3lg6A:
undetectable		 4ccqA-3lg6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 7 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.95A 5b1aC-3lg6A:
2.6
5b1aJ-3lg6A:
undetectable		 5b1aC-3lg6A:
20.29
5b1aJ-3lg6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 7 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.95A 5b1aP-3lg6A:
2.8
5b1aW-3lg6A:
undetectable		 5b1aP-3lg6A:
20.29
5b1aW-3lg6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 7 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.92A 5b3sC-3lg6A:
2.8
5b3sJ-3lg6A:
undetectable		 5b3sC-3lg6A:
20.29
5b3sJ-3lg6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 7 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.90A 5b3sP-3lg6A:
2.6		 5b3sP-3lg6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		3 / 3 ARG A  21
THR A 225
ASP A 224
 None
 0.91A 5g5gA-3lg6A:
undetectable
5g5gB-3lg6A:
undetectable		 5g5gA-3lg6A:
18.33
5g5gB-3lg6A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 7 VAL A 204
PHE A 168
ILE A 174
ASN A 117
 None
 0.96A 5hieC-3lg6A:
undetectable		 5hieC-3lg6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE
(Coccidioides
immitis) 		4 / 5 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.98A 5x1bP-3lg6A:
2.7		 5x1bP-3lg6A:
20.29