SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lga'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		7 / 12 GLY A 101
GLY A 103
SER A 104
ALA A 106
LEU A 107
ARG A 127
ASP A 153
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
None
SAH  A 301 (-3.1A)
 0.50A 1i9gA-3lgaA:
27.0		 1i9gA-3lgaA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 12 GLY A 101
GLY A 103
SER A 104
ALA A 106
LEU A 107
VAL A 176
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
None
 0.78A 1i9gA-3lgaA:
27.0		 1i9gA-3lgaA:
34.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		4 / 8 GLU A  99
GLY A 101
GLU A 125
ASP A 153
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.1A)
 0.77A 1jg4A-3lgaA:
14.1		 1jg4A-3lgaA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLU A  99
GLY A 101
GLY A 103
ILE A 126
ASP A 153
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.1A)
 0.66A 1qaoA-3lgaA:
13.8		 1qaoA-3lgaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
ILE A 126
ASP A 153
ILE A 154
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.3A)
 0.66A 1qaoA-3lgaA:
13.8		 1qaoA-3lgaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
ASP A 153
LEU A 170
PRO A 171
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.2A)
SAH  A 301 (-4.8A)
 0.76A 1zq9B-3lgaA:
15.0		 1zq9B-3lgaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
ARG A 127
ASP A 153
ILE A 154
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
None
SAH  A 301 (-3.1A)
SAH  A 301 (-4.3A)
 0.73A 2b25A-3lgaA:
25.3		 2b25A-3lgaA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 103
SER A 104
ARG A 127
ASP A 153
ILE A 154
 SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
None
SAH  A 301 (-3.1A)
SAH  A 301 (-4.3A)
 0.44A 2b25B-3lgaA:
25.2		 2b25B-3lgaA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		3 / 3 GLY A 101
GLU A 125
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.6A)
 0.39A 2b25B-3lgaA:
25.2		 2b25B-3lgaA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		3 / 3 ASP A  81
ASP A 169
ASN A 221
 None
SAH  A 301 (-3.6A)
None
 0.71A 2bm9D-3lgaA:
10.8		 2bm9D-3lgaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
LEU A 107
ILE A 126
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
 0.72A 2nxeA-3lgaA:
17.6		 2nxeA-3lgaA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
LEU A 107
ILE A 126
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
 0.71A 2nxeB-3lgaA:
17.8		 2nxeB-3lgaA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
GLU A 125
ILE A 126
ARG A 127
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.1A)
None
 0.90A 2vdvE-3lgaA:
12.0		 2vdvE-3lgaA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 11 GLY A 101
GLY A 103
GLU A 125
ILE A 126
ARG A 127
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.1A)
None
 0.90A 2vdvF-3lgaA:
12.0		 2vdvF-3lgaA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 12 ILE A  76
GLY A 101
GLY A 103
SER A 104
ALA A 106
LEU A 107
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
 0.31A 2yvlA-3lgaA:
25.9		 2yvlA-3lgaA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 12 ILE A  76
GLY A 101
GLY A 103
ALA A 106
LEU A 107
ASP A 169
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.6A)
 0.36A 2yvlB-3lgaA:
25.9		 2yvlB-3lgaA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 12 ILE A  76
GLY A 103
SER A 104
ALA A 106
LEU A 107
ASP A 169
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.6A)
 0.41A 2yvlC-3lgaA:
25.5		 2yvlC-3lgaA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 12 GLY A 101
GLY A 103
ALA A 106
LEU A 107
ASP A 153
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
 0.31A 2yvlD-3lgaA:
26.0		 2yvlD-3lgaA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
LEU A 107
ILE A 126
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
 0.75A 2zbpA-3lgaA:
17.6		 2zbpA-3lgaA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		4 / 6 GLY A 101
GLU A 125
ILE A 126
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.6A)
 0.34A 3a7eA-3lgaA:
19.7		 3a7eA-3lgaA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		4 / 6 GLY A 101
ILE A 154
ILE A 126
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.6A)
 0.98A 3a7eA-3lgaA:
19.7		 3a7eA-3lgaA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 11 HIS A 204
PRO A 217
VAL A 177
GLY A 157
GLU A 156
 None
 1.47A 3bf6H-3lgaA:
undetectable		 3bf6H-3lgaA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
LEU A 107
ILE A 126
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
 0.75A 3cjtG-3lgaA:
17.4		 3cjtG-3lgaA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
SER A 104
ILE A 126
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
 1.05A 3cjtG-3lgaA:
17.4		 3cjtG-3lgaA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
LEU A 107
ILE A 126
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
 0.74A 3cjtO-3lgaA:
17.2		 3cjtO-3lgaA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
GLU A 125
ILE A 126
LEU A 107
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.3A)
 0.91A 3ckkA-3lgaA:
12.8		 3ckkA-3lgaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 11 GLY A 101
GLY A 103
GLU A 125
ILE A 126
ASP A 153
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.1A)
 0.66A 3grvA-3lgaA:
15.9		 3grvA-3lgaA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
GLY A 105
ASP A 153
ILE A 154
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.3A)
 0.84A 3ihtA-3lgaA:
11.0		 3ihtA-3lgaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 12 GLY A 101
GLY A 103
GLY A 105
ILE A 154
ASP A 169
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.2A)
 0.93A 3ihtA-3lgaA:
11.0		 3ihtA-3lgaA:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 12 ILE A  76
VAL A  77
ALA A 106
LEU A 107
ILE A 154
LEU A 168
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.3A)
None
 1.44A 3mb5A-3lgaA:
37.9		 3mb5A-3lgaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		12 / 12 ILE A  76
VAL A  77
GLY A 103
SER A 104
ALA A 106
LEU A 107
ILE A 126
ARG A 127
ILE A 154
TYR A 155
LEU A 170
PRO A 171
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.1A)
None
SAH  A 301 (-4.3A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.2A)
SAH  A 301 (-4.8A)
 0.58A 3mb5A-3lgaA:
37.9		 3mb5A-3lgaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		4 / 4 GLY A 101
GLU A 125
ASP A 153
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
 0.23A 3mb5A-3lgaA:
37.9		 3mb5A-3lgaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		4 / 6 GLY A 103
GLU A 125
ASP A 153
ASP A 169
 SAH  A 301 (-3.5A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
 0.72A 3vywC-3lgaA:
11.4		 3vywC-3lgaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
ILE A 126
ASP A 153
ILE A 154
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.3A)
 0.63A 4iv0B-3lgaA:
14.1		 4iv0B-3lgaA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
ILE A 126
ASP A 153
ILE A 154
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.3A)
 0.63A 4iv8A-3lgaA:
14.2		 4iv8A-3lgaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
ILE A 126
ASP A 153
ILE A 154
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.3A)
 0.64A 4iv8B-3lgaA:
14.2		 4iv8B-3lgaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 ASN A 221
ILE A 247
ALA A 192
PHE A 190
VAL A 191
 None
 1.14A 4u8vB-3lgaA:
undetectable		 4u8vB-3lgaA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
ILE A 154
LEU A 107
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.2A)
 1.13A 5bw4A-3lgaA:
11.1		 5bw4A-3lgaA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
LEU A 107
ASP A 169
LEU A 170
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.2A)
 0.68A 5c0oE-3lgaA:
25.8		 5c0oE-3lgaA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 12 GLY A 103
GLY A 105
LEU A 107
GLU A 125
ASP A 169
LEU A 170
 SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.2A)
 0.87A 5c0oF-3lgaA:
24.4		 5c0oF-3lgaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
GLY A 105
LEU A 107
ARG A 127
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.3A)
None
 1.06A 5c0oH-3lgaA:
25.3		 5c0oH-3lgaA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 101
GLY A 103
SER A 104
GLY A 105
LEU A 107
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.3A)
 0.46A 5c0oH-3lgaA:
25.3		 5c0oH-3lgaA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 12 GLN A  75
ILE A  76
VAL A  77
GLY A 105
LEU A 170
PRO A 171
 None
SAH  A 301 (-4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
SAH  A 301 (-4.8A)
 0.79A 5ergB-3lgaA:
23.4		 5ergB-3lgaA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		6 / 7 GLY A 101
GLY A 103
SER A 104
GLU A 125
ASP A 153
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
 0.50A 5ergB-3lgaA:
23.4		 5ergB-3lgaA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 11 GLY A 103
GLU A 125
ILE A 126
ASP A 153
PRO A 171
 SAH  A 301 (-3.5A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.8A)
 1.03A 5hjiA-3lgaA:
15.6		 5hjiA-3lgaA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 ILE A 154
GLY A 101
PHE A 190
ALA A 192
PHE A  96
 SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
None
None
None
 1.23A 5igyA-3lgaA:
undetectable		 5igyA-3lgaA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3lga SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
abyssi) 		5 / 12 GLU A  99
GLY A 101
GLY A 103
ALA A 106
ILE A 126
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.1A)
 0.70A 6iftA-3lgaA:
13.7		 6iftA-3lgaA:
23.20