SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 THR A 116
GLY A 118
MET A 201
GLU A 202
ASP A 225
 SAH  A 268 (-3.8A)
ADE  A 269 ( 3.6A)
SAH  A 268 ( 3.3A)
SAH  A 268 (-3.1A)
ADE  A 269 ( 3.0A)
 0.51A 1jdvE-3lgsA:
20.3
1jdvF-3lgsA:
20.1		 1jdvE-3lgsA:
24.04
1jdvF-3lgsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 GLY A 152
LEU A 155
ASP A 135
VAL A 136
SER A 184
 None
 1.11A 1zq9A-3lgsA:
undetectable		 1zq9A-3lgsA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 ILE A 143
GLY A 152
LEU A 155
ASP A 135
VAL A 136
 None
 1.27A 1zq9A-3lgsA:
undetectable		 1zq9A-3lgsA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		4 / 8 THR A 245
GLY A 250
THR A 251
ALA A 252
 EDO  A2638 ( 4.2A)
None
None
None
 0.86A 2a1hA-3lgsA:
undetectable
2a1hB-3lgsA:
undetectable		 2a1hA-3lgsA:
21.47
2a1hB-3lgsA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 11 THR A 116
GLY A 118
MET A 201
GLU A 202
ASP A 225
 SAH  A 268 (-3.8A)
ADE  A 269 ( 3.6A)
SAH  A 268 ( 3.3A)
SAH  A 268 (-3.1A)
ADE  A 269 ( 3.0A)
 0.53A 2ac7A-3lgsA:
19.9
2ac7B-3lgsA:
19.9		 2ac7A-3lgsA:
24.21
2ac7B-3lgsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 11 THR A 116
GLY A 118
MET A 201
GLU A 202
ASP A 225
 SAH  A 268 (-3.8A)
ADE  A 269 ( 3.6A)
SAH  A 268 ( 3.3A)
SAH  A 268 (-3.1A)
ADE  A 269 ( 3.0A)
 0.52A 2ac7A-3lgsA:
19.9
2ac7B-3lgsA:
19.9		 2ac7A-3lgsA:
24.21
2ac7B-3lgsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 LEU A 164
LEU A 220
LYS A 221
ILE A 256
LEU A  42
 None
 1.07A 2oipE-3lgsA:
undetectable		 2oipE-3lgsA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 LEU A 164
LEU A 220
LYS A 221
ILE A 256
LEU A  42
 None
 1.10A 3hj3B-3lgsA:
undetectable		 3hj3B-3lgsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 LEU A 168
LEU A 220
LYS A 221
ILE A 256
LEU A  42
 None
 1.16A 3hj3B-3lgsA:
undetectable		 3hj3B-3lgsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 11 THR A 116
GLY A 118
MET A 201
GLU A 202
ASP A 225
 SAH  A 268 (-3.8A)
ADE  A 269 ( 3.6A)
SAH  A 268 ( 3.3A)
SAH  A 268 (-3.1A)
ADE  A 269 ( 3.0A)
 0.53A 3uawA-3lgsA:
21.1		 3uawA-3lgsA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 TYR A  65
ILE A  74
VAL A  76
ILE A 112
ILE A 256
 None
 0.99A 3vrjA-3lgsA:
undetectable
3vrjC-3lgsA:
undetectable		 3vrjA-3lgsA:
22.04
3vrjC-3lgsA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 LEU A 164
LEU A 220
LYS A 221
ILE A 256
LEU A  42
 None
 1.08A 4ky8B-3lgsA:
undetectable		 4ky8B-3lgsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 ASP A 200
SER A 134
GLY A 203
GLY A 173
ASP A 135
 SAH  A 268 ( 4.9A)
None
None
None
None
 1.33A 4pevB-3lgsA:
5.4		 4pevB-3lgsA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 LEU A 164
LEU A 220
LYS A 221
ILE A 256
LEU A  42
 None
 1.14A 4q0dA-3lgsA:
undetectable		 4q0dA-3lgsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 LEU A 164
LEU A 220
LYS A 221
ILE A 256
LEU A  42
 None
 1.14A 4q0dB-3lgsA:
undetectable		 4q0dB-3lgsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 LEU A 164
LEU A 220
LYS A 221
ILE A 256
LEU A  42
 None
 1.14A 4q0dE-3lgsA:
undetectable		 4q0dE-3lgsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		4 / 5 ALA A  95
THR A  99
VAL A 217
ILE A 111
 None
 0.88A 4xe3A-3lgsA:
undetectable		 4xe3A-3lgsA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		4 / 8 ILE A 111
ALA A 205
VAL A 209
VAL A  32
 None
 0.90A 5ecnD-3lgsA:
0.4		 5ecnD-3lgsA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 ASP A 179
ALA A 204
ALA A 205
VAL A 209
GLY A 152
 None
 1.06A 5igjA-3lgsA:
undetectable		 5igjA-3lgsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 ILE A 215
PRO A 108
ALA A  34
VAL A  77
GLY A 115
 None
None
SAH  A 268 ( 4.4A)
None
None
 1.04A 5igtA-3lgsA:
undetectable		 5igtA-3lgsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		5 / 12 GLN A 104
ALA A 101
LEU A 213
ILE A 215
VAL A  32
 None
 1.29A 5vlmG-3lgsA:
undetectable		 5vlmG-3lgsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES
(Arabidopsis
thaliana) 		4 / 8 PRO A  55
LYS A  58
THR A  52
THR A  51
 None
 1.28A 5x2sI-3lgsA:
undetectable
5x2sJ-3lgsA:
undetectable
5x2sK-3lgsA:
undetectable		 5x2sI-3lgsA:
20.99
5x2sJ-3lgsA:
21.72
5x2sK-3lgsA:
20.99