SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 7 ARG A 396
ASP A 267
TYR A 393
TYR A 292
 ATP  A 600 (-4.2A)
ATP  A 600 (-4.1A)
ATP  A 600 ( 3.7A)
None
 1.20A 1cebA-3lgxA:
undetectable		 1cebA-3lgxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 4 ILE A  37
LEU A  46
VAL A  52
ILE A 101
 None
 0.93A 1fm6D-3lgxA:
undetectable		 1fm6D-3lgxA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		3 / 3 GLU A 345
HIS A 378
ASP A 332
 None
 0.78A 1i9gA-3lgxA:
2.2		 1i9gA-3lgxA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 7 ILE A 236
THR A 238
MET A 186
MET A 172
 None
 0.67A 1kglA-3lgxA:
undetectable		 1kglA-3lgxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 12 GLY A 373
ASN A 164
SER A 161
ILE A 160
GLY A 356
 None
 1.03A 1q8jB-3lgxA:
undetectable		 1q8jB-3lgxA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 4 LEU A  21
PRO A 190
ILE A 229
LEU A 232
 None
 1.05A 1ya4C-3lgxA:
undetectable		 1ya4C-3lgxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		3 / 3 LEU A 196
MET A 199
MET A  62
 None
 1.01A 2vavF-3lgxA:
undetectable		 2vavF-3lgxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 7 LEU A 196
GLY A 268
GLY A 293
THR A 295
 None
ATP  A 600 (-3.4A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-3.6A)
 0.67A 2wd9A-3lgxA:
41.2		 2wd9A-3lgxA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 8 LEU A 196
GLY A 268
GLY A 293
THR A 295
 None
ATP  A 600 (-3.4A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-3.6A)
 0.67A 2wd9B-3lgxA:
40.1		 2wd9B-3lgxA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 10 THR A 148
LEU A 196
GLY A 268
GLY A 293
THR A 295
 ATP  A 600 (-3.7A)
None
ATP  A 600 (-3.4A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-3.6A)
 0.86A 2wd9C-3lgxA:
39.8		 2wd9C-3lgxA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 6 THR A  70
VAL A  67
GLU A   6
SER A  34
 None
 1.12A 3b6rB-3lgxA:
undetectable		 3b6rB-3lgxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 4 LEU A 118
ASP A  80
VAL A  54
THR A  65
 None
 0.81A 3cyxB-3lgxA:
undetectable		 3cyxB-3lgxA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 12 ALA A 102
ILE A 121
ILE A  41
SER A  43
LEU A  46
 None
 0.94A 3k2hB-3lgxA:
undetectable		 3k2hB-3lgxA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 11 ILE A 319
ALA A 291
ASP A 267
SER A 326
LEU A 391
 ATP  A 600 ( 4.7A)
None
ATP  A 600 (-4.1A)
None
None
 1.34A 3qg2B-3lgxA:
undetectable		 3qg2B-3lgxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 7 PHE A 194
ASP A 195
GLY A 268
THR A 295
LYS A 495
 ATP  A 600 ( 4.9A)
None
ATP  A 600 (-3.4A)
ATP  A 600 (-3.6A)
ATP  A 600 (-2.9A)
 0.65A 3vnsA-3lgxA:
49.6		 3vnsA-3lgxA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 6 LEU A 410
TYR A 432
ASN A 506
VAL A 505
 None
 0.91A 4a9kA-3lgxA:
undetectable		 4a9kA-3lgxA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 12 VAL A 180
ALA A 303
PHE A 168
LEU A 205
THR A 169
 None
 1.46A 4iarA-3lgxA:
undetectable		 4iarA-3lgxA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 7 PHE A 194
ASP A 195
GLY A 268
THR A 295
LYS A 495
 ATP  A 600 ( 4.9A)
None
ATP  A 600 (-3.4A)
ATP  A 600 (-3.6A)
ATP  A 600 (-2.9A)
 0.53A 4zxiA-3lgxA:
45.5		 4zxiA-3lgxA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		3 / 3 GLU A 345
HIS A 378
ASP A 332
 None
 0.75A 5c0oG-3lgxA:
2.2		 5c0oG-3lgxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 6 PHE A  40
SER A  72
ALA A  38
HIS A  74
 None
 1.30A 5dzkg-3lgxA:
undetectable
5dzku-3lgxA:
undetectable		 5dzkg-3lgxA:
18.41
5dzku-3lgxA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 8 LEU A 261
ALA A 244
PHE A 266
PRO A 181
 None
 0.92A 5m0oC-3lgxA:
undetectable		 5m0oC-3lgxA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 9 PRO A  97
ILE A  91
ILE A  94
VAL A  79
ILE A 145
 None
 1.46A 5mzrD-3lgxA:
undetectable		 5mzrD-3lgxA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 4 GLY A 208
ALA A 206
MET A 186
THR A 169
 None
 1.40A 5n0sB-3lgxA:
undetectable		 5n0sB-3lgxA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 7 PHE A 194
ASP A 195
GLY A 268
GLY A 293
LYS A 495
 ATP  A 600 ( 4.9A)
None
ATP  A 600 (-3.4A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-2.9A)
 0.59A 5n9xA-3lgxA:
49.4		 5n9xA-3lgxA:
31.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 6 PHE A 243
PRO A 241
ALA A 244
THR A 275
 None
 1.11A 5t7bA-3lgxA:
2.5		 5t7bA-3lgxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 4 LEU A  63
LEU A 211
SER A 197
ALA A 188
 None
 1.12A 5uunA-3lgxA:
undetectable		 5uunA-3lgxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		5 / 12 GLY A 320
ILE A 289
GLU A 305
ALA A 291
ASP A 175
 None
 1.18A 5x7fA-3lgxA:
undetectable		 5x7fA-3lgxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1
(Streptococcus
pyogenes) 		4 / 6 PHE A 280
ARG A 277
LEU A 279
ALA A 286
 None
 1.08A 6b89B-3lgxA:
undetectable		 6b89B-3lgxA:
9.33