SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lh5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lh5 TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		3 / 3 SER A 758
ASP A 655
CYH A 744
 None
 1.12A 2br4E-3lh5A:
undetectable		 2br4E-3lh5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3lh5 TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		3 / 3 LEU A 535
ARG A 571
ILE A 574
 None
 0.52A 2xn5B-3lh5A:
undetectable		 2xn5B-3lh5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3lh5 TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 9 ILE A 560
ILE A 562
PHE A 543
LEU A 535
ALA A 559
 None
 1.10A 3ozvB-3lh5A:
undetectable		 3ozvB-3lh5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3lh5 TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		4 / 8 TYR A 669
TYR A 783
LEU A 728
TRP A 782
 None
 1.17A 3uzzB-3lh5A:
undetectable		 3uzzB-3lh5A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3lh5 TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		3 / 3 GLU A 634
ARG A 522
HIS A 524
 None
 0.85A 4kf9A-3lh5A:
undetectable		 4kf9A-3lh5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3lh5 TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 12 LEU A 583
GLY A 555
GLY A 552
LEU A 549
ASN A 578
 None
 0.99A 4x61A-3lh5A:
undetectable		 4x61A-3lh5A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 3lh5 TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		4 / 6 GLN A 720
ASN A 717
VAL A 800
LEU A 638
 None
 1.23A 5xdhA-3lh5A:
undetectable
5xdhC-3lh5A:
undetectable		 5xdhA-3lh5A:
16.26
5xdhC-3lh5A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3lh5 TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 12 GLN A 796
THR A 771
THR A 770
VAL A 725
THR A 648
 None
 1.42A 6ak3A-3lh5A:
undetectable		 6ak3A-3lh5A:
20.88