SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lhl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		4 / 8 HIS A 136
ASP A 138
SER A 149
ASP A 215
 MN  A 302 (-3.5A)
MN  A 301 ( 2.8A)
None
MN  A 302 (-2.6A)
 1.21A 1p7lC-3lhlA:
undetectable		 1p7lC-3lhlA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		4 / 8 HIS A 136
ASP A 138
SER A 149
ASP A 215
 MN  A 302 (-3.5A)
MN  A 301 ( 2.8A)
None
MN  A 302 (-2.6A)
 1.21A 1p7lD-3lhlA:
undetectable		 1p7lD-3lhlA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		5 / 11 LEU A 212
THR A 213
ILE A 246
ILE A 201
VAL A 202
 None
 1.15A 1pkvA-3lhlA:
undetectable
1pkvB-3lhlA:
undetectable		 1pkvA-3lhlA:
15.73
1pkvB-3lhlA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		5 / 11 ILE A 201
VAL A 202
LEU A 212
THR A 213
ILE A 246
 None
 1.19A 1pkvA-3lhlA:
undetectable
1pkvB-3lhlA:
undetectable		 1pkvA-3lhlA:
15.73
1pkvB-3lhlA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		5 / 12 ILE A 247
ILE A 254
VAL A 103
VAL A 121
ILE A 128
 None
 1.31A 1r5lA-3lhlA:
undetectable		 1r5lA-3lhlA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		3 / 3 PRO A  59
ASP A  62
ASP A  64
 None
 0.81A 1sqfA-3lhlA:
undetectable		 1sqfA-3lhlA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		4 / 8 LEU A  23
ILE A  70
LEU A 285
ILE A 286
 None
 0.87A 2azxA-3lhlA:
undetectable		 2azxA-3lhlA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		4 / 8 ILE A  97
ASN A  22
TYR A  18
SER A 101
 None
 1.06A 2zw9B-3lhlA:
3.4		 2zw9B-3lhlA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		5 / 12 THR A 229
THR A 227
HIS A 150
ILE A 171
TYR A 143
 None
None
PO4  A 305 ( 4.2A)
None
PO4  A 305 ( 4.5A)
 1.34A 3gwxA-3lhlA:
undetectable		 3gwxA-3lhlA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		4 / 7 LEU A  54
VAL A 103
ILE A  70
MET A  47
 None
 1.20A 3ik3A-3lhlA:
undetectable		 3ik3A-3lhlA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		4 / 7 LEU A  54
VAL A 103
ILE A  70
MET A  47
 None
 1.25A 3ik3B-3lhlA:
undetectable		 3ik3B-3lhlA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		5 / 12 THR A 114
ASP A 258
VAL A 130
ILE A 166
ILE A 154
 None
 1.06A 3kpdC-3lhlA:
undetectable		 3kpdC-3lhlA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		3 / 3 ARG A 156
LEU A 115
THR A  33
 None
 0.84A 3oxcA-3lhlA:
undetectable		 3oxcA-3lhlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		4 / 8 ASN A 144
GLU A 178
HIS A 136
THR A  83
 PO4  A 305 (-4.5A)
None
MN  A 302 (-3.5A)
None
 1.41A 5hqaA-3lhlA:
undetectable		 5hqaA-3lhlA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		5 / 11 ASP A 258
VAL A  98
ILE A  97
ILE A 160
ILE A 157
 None
 1.17A 5hw8A-3lhlA:
undetectable
5hw8D-3lhlA:
undetectable		 5hw8A-3lhlA:
19.15
5hw8D-3lhlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		4 / 8 TYR A 211
ASP A 258
ILE A  97
ILE A 107
 None
 0.99A 5hw8H-3lhlA:
undetectable		 5hw8H-3lhlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		5 / 12 MET A 106
GLU A 282
LEU A 280
TYR A 237
PHE A 240
 None
 1.22A 5vlmE-3lhlA:
undetectable		 5vlmE-3lhlA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		5 / 12 LEU A 216
ILE A 214
CYH A 257
LEU A  23
ILE A 107
 None
 1.07A 5y2tB-3lhlA:
undetectable		 5y2tB-3lhlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		3 / 3 GLY A 270
THR A 273
GLU A  50
 None
 0.62A 6b58A-3lhlA:
undetectable		 6b58A-3lhlA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		5 / 12 PRO A 104
PHE A 105
PHE A 169
PHE A 133
ILE A 128
 None
 1.44A 6becA-3lhlA:
undetectable
6becB-3lhlA:
undetectable
6becC-3lhlA:
undetectable		 6becA-3lhlA:
19.27
6becB-3lhlA:
19.27
6becC-3lhlA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 3lhl PUTATIVE AGMATINASE
(Clostridioides
difficile) 		3 / 3 TRP A 158
ILE A 160
ASP A 159
 None
 0.74A 6i0y7-3lhlA:
undetectable		 6i0y7-3lhlA:
6.27