SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		5 / 11 THR A  74
VAL A 105
TYR A  78
LEU A  93
ILE A  89
 None
 1.35A 1t6zB-3libA:
undetectable		 1t6zB-3libA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		5 / 12 TYR A 155
GLY A 196
SER A  72
ALA A  86
PHE A 131
 None
 0.94A 1ve3A-3libA:
undetectable		 1ve3A-3libA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		5 / 12 TYR A 155
GLY A 196
SER A  72
ALA A  86
PHE A 131
 None
 1.00A 1ve3B-3libA:
undetectable		 1ve3B-3libA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		3 / 3 PRO A 133
PHE A 112
ALA A  86
 None
 0.73A 3itaD-3libA:
2.1		 3itaD-3libA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		5 / 10 LEU A  90
PHE A 107
ALA A 106
GLY A 195
ILE A  71
 None
 1.10A 3qpsA-3libA:
undetectable		 3qpsA-3libA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		4 / 7 TYR A 156
ASP A 110
ALA A 111
ASP A 116
 None
 0.86A 3rodD-3libA:
undetectable		 3rodD-3libA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		4 / 4 VAL A 207
PHE A  57
PHE A 289
VAL A 179
 None
 1.22A 3rv5C-3libA:
undetectable
3rv5D-3libA:
undetectable		 3rv5C-3libA:
16.49
3rv5D-3libA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		4 / 7 PRO A 170
GLU A 169
ASP A 270
THR A 268
 None
 1.15A 4uacA-3libA:
undetectable		 4uacA-3libA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		4 / 6 ARG A  83
ARG A 130
ASP A 126
ASP A 116
 None
 1.41A 4xqeA-3libA:
undetectable		 4xqeA-3libA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE
(Methanosarcina
mazei) 		4 / 6 ARG A  83
ARG A 130
ASP A 126
ASP A 116
 None
 1.39A 4xqeB-3libA:
undetectable		 4xqeB-3libA:
21.08