SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		3 / 3 MET A  56
LEU A  59
SER A  60
 None
 0.53A 1ee2A-3lifA:
undetectable		 1ee2A-3lifA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		4 / 4 ILE A  81
ASP A 111
LEU A 121
ARG A  98
 None
MPD  A   1 ( 4.3A)
None
None
 1.39A 2a7qA-3lifA:
undetectable		 2a7qA-3lifA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		5 / 11 MET A 230
GLY A 256
VAL A 251
ASP A 255
ARG A 228
 None
 1.44A 2ac7A-3lifA:
undetectable
2ac7B-3lifA:
undetectable		 2ac7A-3lifA:
22.03
2ac7B-3lifA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		5 / 11 ARG A 228
MET A 230
GLY A 256
VAL A 251
ASP A 255
 None
 1.43A 2ac7A-3lifA:
undetectable
2ac7B-3lifA:
undetectable		 2ac7A-3lifA:
22.03
2ac7B-3lifA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		4 / 6 ARG A 216
GLY A 155
PHE A 167
THR A 187
 None
None
None
MPD  A   1 ( 4.6A)
 1.28A 2m2oB-3lifA:
undetectable		 2m2oB-3lifA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		4 / 4 ALA A 117
VAL A 183
PHE A 181
THR A 122
 None
 1.44A 2pkkA-3lifA:
undetectable		 2pkkA-3lifA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		5 / 12 SER A 170
ASP A 111
SER A 138
ASN A 134
ASP A 136
 None
MPD  A   1 ( 4.3A)
None
None
None
 1.38A 3havC-3lifA:
undetectable		 3havC-3lifA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		5 / 12 ARG A 228
MET A 230
GLY A 256
VAL A 251
ASP A 255
 None
 1.44A 3u40B-3lifA:
undetectable
3u40C-3lifA:
undetectable		 3u40B-3lifA:
22.34
3u40C-3lifA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		5 / 11 MET A 230
GLY A 256
VAL A 251
ASP A 255
ARG A 228
 None
 1.44A 3u40D-3lifA:
undetectable
3u40E-3lifA:
undetectable		 3u40D-3lifA:
22.34
3u40E-3lifA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		5 / 12 ARG A 228
MET A 230
GLY A 256
VAL A 251
ASP A 255
 None
 1.48A 3u40D-3lifA:
undetectable
3u40E-3lifA:
undetectable		 3u40D-3lifA:
22.34
3u40E-3lifA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		4 / 8 TYR A 269
THR A 150
HIS A 212
PHE A 193
 None
 1.37A 4tzcB-3lifA:
undetectable
4tzcD-3lifA:
undetectable		 4tzcB-3lifA:
18.99
4tzcD-3lifA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		5 / 9 VAL A 168
LEU A 106
SER A 125
LEU A 102
ILE A  81
 None
 1.26A 4ubsA-3lifA:
undetectable		 4ubsA-3lifA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		3 / 3 ASP A 133
GLY A 119
ASP A 116
 None
 0.64A 4xdtA-3lifA:
undetectable		 4xdtA-3lifA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		4 / 5 THR A  68
GLN A  72
ARG A 268
GLU A  65
 None
 1.28A 5k9dA-3lifA:
undetectable		 5k9dA-3lifA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN
(Rhodopseudomonas
palustris) 		4 / 9 HIS A  45
LEU A 261
VAL A 251
SER A 252
 None
 0.99A 6c2mD-3lifA:
undetectable		 6c2mD-3lifA:
16.81