SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lim'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		5 / 12 GLY A  36
VAL A  18
LEU A  19
LEU A  71
HIS A 175
 None
 1.02A 1mx1F-3limA:
undetectable		 1mx1F-3limA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 6 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.47A 1nsiA-3limA:
undetectable
1nsiB-3limA:
undetectable		 1nsiA-3limA:
18.24
1nsiB-3limA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 6 TRP A 117
PHE A 143
ARG A 152
ILE A 174
 None
 1.46A 1nsiA-3limA:
undetectable
1nsiB-3limA:
undetectable		 1nsiA-3limA:
18.24
1nsiB-3limA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 6 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.47A 1nsiC-3limA:
undetectable
1nsiD-3limA:
undetectable		 1nsiC-3limA:
18.24
1nsiD-3limA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 6 TRP A 117
PHE A 143
ARG A 152
ILE A 174
 None
 1.49A 1nsiC-3limA:
undetectable
1nsiD-3limA:
undetectable		 1nsiC-3limA:
18.24
1nsiD-3limA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		3 / 3 GLY A  11
GLU A  40
ASP A  10
 None
 0.62A 2b25B-3limA:
undetectable		 2b25B-3limA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 7 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.45A 2nsiA-3limA:
undetectable
2nsiB-3limA:
undetectable		 2nsiA-3limA:
18.24
2nsiB-3limA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 7 TRP A 117
PHE A 143
ARG A 152
ILE A 174
 None
 1.47A 2nsiA-3limA:
undetectable
2nsiB-3limA:
undetectable		 2nsiA-3limA:
18.24
2nsiB-3limA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 7 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.49A 2nsiC-3limA:
undetectable
2nsiD-3limA:
undetectable		 2nsiC-3limA:
18.24
2nsiD-3limA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 7 TRP A 117
PHE A 143
ARG A 152
ILE A 174
 None
 1.48A 2nsiC-3limA:
undetectable
2nsiD-3limA:
undetectable		 2nsiC-3limA:
18.24
2nsiD-3limA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 8 GLU A 173
LEU A  14
THR A  21
VAL A  22
 None
 0.90A 3ax9A-3limA:
undetectable		 3ax9A-3limA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 7 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.45A 3e7gA-3limA:
undetectable
3e7gB-3limA:
undetectable		 3e7gA-3limA:
16.35
3e7gB-3limA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 7 TRP A 117
PHE A 143
ARG A 152
ILE A 174
 None
 1.45A 3e7gA-3limA:
undetectable
3e7gB-3limA:
undetectable		 3e7gA-3limA:
16.35
3e7gB-3limA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 7 ARG A 152
ILE A 174
TRP A 117
PHE A 143
 None
 1.47A 3e7gC-3limA:
undetectable
3e7gD-3limA:
undetectable		 3e7gC-3limA:
16.35
3e7gD-3limA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 8 TRP A 117
PHE A 143
ARG A 152
ILE A 174
 None
 1.46A 3e7gC-3limA:
undetectable
3e7gD-3limA:
undetectable		 3e7gC-3limA:
16.35
3e7gD-3limA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		4 / 6 TRP A 117
PHE A 143
ARG A 152
ILE A 174
 None
 1.49A 4nosC-3limA:
undetectable
4nosD-3limA:
undetectable		 4nosC-3limA:
17.59
4nosD-3limA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		5 / 12 GLY A  13
GLU A  40
VAL A  18
ASP A  10
ILE A   9
 None
 0.88A 5ec8A-3limA:
undetectable		 5ec8A-3limA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		5 / 12 GLY A  13
GLU A  40
VAL A  18
ASP A  10
ILE A   9
 None
 0.94A 5ehgC-3limA:
undetectable		 5ehgC-3limA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		3 / 3 TYR A 110
TYR A 133
SER A  54
 None
LDA  A 201 (-4.4A)
LDA  A 201 ( 4.9A)
 0.50A 5iktB-3limA:
undetectable		 5iktB-3limA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		5 / 12 GLY A  13
GLU A  40
VAL A  18
ASP A  10
ILE A   9
 None
 0.93A 5njvC-3limA:
undetectable		 5njvC-3limA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		5 / 12 GLY A  13
GLU A  40
VAL A  18
ASP A  10
ILE A   9
 None
 1.05A 5wz1D-3limA:
undetectable		 5wz1D-3limA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		5 / 12 GLY A  13
GLU A  40
VAL A  18
ASP A  10
ILE A   9
 None
 0.66A 5wz2C-3limA:
undetectable		 5wz2C-3limA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3lim FRAGACEATOXIN C
(Actinia
fragacea) 		3 / 3 LYS A  69
VAL A   8
ASP A  10
 None
 0.52A 6fgdA-3limA:
undetectable		 6fgdA-3limA:
17.32