SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ljn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3ljn HYPOTHETICAL PROTEIN
(Leishmania
major) 		4 / 6 PRO A 272
ASN A 238
ASP A 237
TYR A 245
 None
 1.33A 1hpkA-3ljnA:
undetectable		 1hpkA-3ljnA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3ljn HYPOTHETICAL PROTEIN
(Leishmania
major) 		3 / 3 VAL A 227
GLU A 258
GLU A 228
 None
 0.79A 2nv4A-3ljnA:
undetectable		 2nv4A-3ljnA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3ljn HYPOTHETICAL PROTEIN
(Leishmania
major) 		5 / 9 PHE A 179
ARG A 120
ALA A  90
GLY A 143
LEU A 144
 None
 1.21A 2v0mB-3ljnA:
undetectable		 2v0mB-3ljnA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ljn HYPOTHETICAL PROTEIN
(Leishmania
major) 		3 / 3 ASP A 264
LEU A 267
PHE A 266
 None
 0.65A 4pthA-3ljnA:
undetectable		 4pthA-3ljnA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3ljn HYPOTHETICAL PROTEIN
(Leishmania
major) 		4 / 4 CYH A  57
LEU A  53
LEU A  99
ALA A  69
 None
 1.08A 5hpuA-3ljnA:
undetectable
5hpuB-3ljnA:
undetectable		 5hpuA-3ljnA:
5.38
5hpuB-3ljnA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ljn HYPOTHETICAL PROTEIN
(Leishmania
major) 		3 / 3 THR A 256
THR A 241
LEU A 216
 None
 0.51A 5m66D-3ljnA:
undetectable		 5m66D-3ljnA:
22.49