SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		3 / 3 GLU A  22
ALA A  24
SER A 152
 None
 0.69A 1errB-3lk7A:
undetectable		 1errB-3lk7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		4 / 7 GLN A 315
LEU A 341
SER A 422
SER A 329
 None
 1.05A 1ig3A-3lk7A:
undetectable
1ig3B-3lk7A:
4.5		 1ig3A-3lk7A:
20.04
1ig3B-3lk7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 LEU A 351
ILE A 334
ALA A 424
VAL A 385
ALA A 353
 None
 1.12A 2japA-3lk7A:
2.3		 2japA-3lk7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 LEU A 351
ILE A 334
ALA A 424
VAL A 385
ALA A 353
 None
 1.15A 2japB-3lk7A:
2.5		 2japB-3lk7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 LEU A 351
ILE A 334
ALA A 424
VAL A 385
ALA A 353
 None
 1.13A 2japC-3lk7A:
2.5		 2japC-3lk7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 LEU A 351
ILE A 334
ALA A 424
VAL A 385
ALA A 353
 None
 1.12A 2japD-3lk7A:
2.5		 2japD-3lk7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		3 / 3 SER A 383
GLU A  45
ASP A  39
 None
 0.83A 2zulA-3lk7A:
4.6		 2zulA-3lk7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		3 / 3 SER A 383
GLU A  45
ASP A  39
 None
 0.83A 3dmhA-3lk7A:
2.8		 3dmhA-3lk7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 THR A 125
THR A 128
LEU A 304
ILE A 272
LEU A 143
 None
 1.24A 3gwxB-3lk7A:
undetectable		 3gwxB-3lk7A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 GLU A 167
VAL A 289
PHE A 149
ARG A  19
ILE A 117
 SO4  A 452 ( 4.6A)
None
None
CL  A 454 (-4.4A)
None
 1.15A 3k13C-3lk7A:
undetectable		 3k13C-3lk7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		4 / 8 GLU A 264
ASN A 265
ASN A 297
ILE A 287
 None
None
SO4  A 453 (-3.5A)
None
 0.78A 3kp6A-3lk7A:
undetectable
3kp6B-3lk7A:
undetectable		 3kp6A-3lk7A:
15.93
3kp6B-3lk7A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		4 / 6 ASN A 297
ILE A 287
GLU A 264
ASN A 265
 SO4  A 453 (-3.5A)
None
None
None
 0.76A 3kp6A-3lk7A:
undetectable
3kp6B-3lk7A:
undetectable		 3kp6A-3lk7A:
15.93
3kp6B-3lk7A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		6 / 12 LEU A  52
ALA A  29
ILE A  34
ILE A  77
VAL A  59
ILE A  57
 None
 1.19A 3ndtA-3lk7A:
undetectable		 3ndtA-3lk7A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		4 / 5 ILE A 272
ARG A 313
THR A 125
GLU A 132
 None
 1.27A 3ny4A-3lk7A:
undetectable		 3ny4A-3lk7A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 11 LEU A 420
ARG A 437
SER A 331
LEU A 351
LEU A 314
 None
 1.47A 4or0A-3lk7A:
undetectable		 4or0A-3lk7A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 LEU A 304
VAL A 133
THR A 126
PHE A 243
GLY A 119
 None
 1.21A 4q15A-3lk7A:
2.0		 4q15A-3lk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 LEU A 304
VAL A 133
THR A 126
PHE A 243
GLY A 119
 None
 1.19A 4q15B-3lk7A:
3.0		 4q15B-3lk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 11 LEU A 220
GLY A 227
ILE A 228
THR A 236
ILE A 240
 None
 0.98A 4rvjC-3lk7A:
undetectable		 4rvjC-3lk7A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 ASP A 404
PHE A 325
PHE A 441
ILE A 352
HIS A 374
 None
 1.16A 4wh5A-3lk7A:
undetectable		 4wh5A-3lk7A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 9 SER A 229
PHE A 224
VAL A 185
LEU A 222
VAL A 221
 None
 1.39A 4z69A-3lk7A:
undetectable		 4z69A-3lk7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		4 / 6 LYS A 311
PHE A 445
SER A 427
ASP A 439
 None
None
CL  A 454 ( 4.6A)
None
 0.93A 5hesA-3lk7A:
undetectable		 5hesA-3lk7A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 10 VAL A 406
ILE A 352
ARG A 437
GLY A 438
PHE A 441
 None
 1.18A 5mxbA-3lk7A:
undetectable		 5mxbA-3lk7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 9 ILE A 352
GLY A 438
PHE A 441
ASN A 327
ALA A 426
 None
 1.23A 5x66C-3lk7A:
undetectable		 5x66C-3lk7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 10 ILE A 352
GLY A 438
PHE A 441
ASN A 327
ALA A 426
 None
 1.25A 5x66D-3lk7A:
undetectable		 5x66D-3lk7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 PHE A 362
ILE A 334
LEU A 365
ALA A 353
LEU A 351
 None
 1.30A 5zwrB-3lk7A:
undetectable		 5zwrB-3lk7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE
(Streptococcus
agalactiae) 		5 / 12 GLY A 273
GLY A 309
ASP A 271
ILE A 287
ASN A 306
 None
 1.07A 6mhtA-3lk7A:
2.9		 6mhtA-3lk7A:
25.65