SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A  80
LEU A  83
SER A 144
ILE A 143
LEU A 251
 None
 1.04A 1dreA-3lkeA:
undetectable		 1dreA-3lkeA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A 146
LEU A  54
LEU A  19
ARG A 126
GLY A 114
 None
 1.15A 1jffB-3lkeA:
2.6		 1jffB-3lkeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A  80
LEU A  83
SER A 144
ILE A 143
LEU A 251
 None
 1.01A 1rh3A-3lkeA:
undetectable		 1rh3A-3lkeA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A  80
LEU A  83
SER A 144
ILE A 143
LEU A 251
 None
 1.05A 1rx3A-3lkeA:
undetectable		 1rx3A-3lkeA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A 146
LEU A  54
LEU A  19
ARG A 126
GLY A 114
 None
 1.15A 2hxfB-3lkeA:
2.6		 2hxfB-3lkeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A 146
LEU A  54
LEU A  19
ARG A 126
GLY A 114
 None
 1.15A 2hxhB-3lkeA:
2.6		 2hxhB-3lkeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A 146
LEU A  54
LEU A  19
ARG A 126
GLY A 114
 None
 1.15A 2p4nB-3lkeA:
2.6		 2p4nB-3lkeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A 146
LEU A  54
LEU A  19
ARG A 126
GLY A 114
 None
 1.15A 2wbeB-3lkeA:
2.6		 2wbeB-3lkeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		3 / 3 GLY A 116
GLY A  27
GLY A  65
 None
 0.44A 3bogC-3lkeA:
undetectable		 3bogC-3lkeA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		3 / 3 GLY A 116
GLY A  27
GLY A  65
 None
 0.38A 3bogD-3lkeA:
undetectable		 3bogD-3lkeA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A 146
LEU A  54
LEU A  19
ARG A 126
GLY A 114
 None
 1.15A 3dcoB-3lkeA:
2.6		 3dcoB-3lkeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A 146
LEU A  54
LEU A  19
ARG A 126
GLY A 114
 None
 1.15A 3edlB-3lkeA:
2.6		 3edlB-3lkeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A 146
LEU A  54
LEU A  19
ARG A 126
GLY A 114
 None
 1.14A 3iz0B-3lkeA:
2.6		 3iz0B-3lkeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 LEU A  28
ALA A 112
GLY A 115
MET A 120
ALA A 132
 None
 1.23A 3ou6C-3lkeA:
undetectable		 3ou6C-3lkeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 LEU A  28
ALA A 112
GLY A 115
MET A 120
ALA A 132
 None
 1.21A 3ou7C-3lkeA:
undetectable		 3ou7C-3lkeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		3 / 3 LYS A 102
VAL A 209
HIS A  50
 None
 1.03A 3tj7A-3lkeA:
undetectable		 3tj7A-3lkeA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ILE A 143
LEU A 251
GLY A 114
ASN A 118
LEU A  68
 None
 1.04A 3vaqB-3lkeA:
3.2		 3vaqB-3lkeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ILE A 143
LEU A 251
GLY A 114
ASN A 118
LEU A  68
 None
 1.04A 3vasB-3lkeA:
undetectable		 3vasB-3lkeA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		4 / 8 LEU A  28
SER A  64
ASP A  20
TYR A  21
 None
 1.01A 4drjB-3lkeA:
undetectable		 4drjB-3lkeA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A  80
LEU A  83
SER A 144
ILE A 143
LEU A 251
 None
 0.88A 4ky8A-3lkeA:
undetectable		 4ky8A-3lkeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A  80
LEU A  83
SER A 144
ILE A 143
LEU A 251
 None
 0.82A 4ky8B-3lkeA:
undetectable		 4ky8B-3lkeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A  80
LEU A  83
SER A 144
ILE A 143
LEU A 251
 None
 1.00A 4ky8C-3lkeA:
undetectable		 4ky8C-3lkeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A  80
LEU A  83
SER A 144
ILE A 143
LEU A 251
 None
 0.86A 4ky8D-3lkeA:
2.1		 4ky8D-3lkeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 ASP A  80
LEU A  83
SER A 144
ILE A 143
LEU A 251
 None
 0.80A 4ky8E-3lkeA:
undetectable		 4ky8E-3lkeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 LEU A  19
ALA A 106
LEU A  36
GLY A 116
VAL A  94
 None
 0.86A 4nkvB-3lkeA:
undetectable		 4nkvB-3lkeA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		3 / 3 LYS A 102
ILE A  52
ILE A  17
 None
 0.69A 4y0qA-3lkeA:
undetectable		 4y0qA-3lkeA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		4 / 5 ILE A 127
ARG A 196
CYH A 187
GLU A 188
 None
 1.01A 5fseC-3lkeA:
2.6		 5fseC-3lkeA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 LEU A 251
LEU A 254
PRO A  66
LEU A 147
LEU A  87
 None
 1.10A 5ljeA-3lkeA:
undetectable		 5ljeA-3lkeA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		4 / 5 LEU A  28
CYH A  74
LEU A  83
ASP A 146
 None
 1.31A 5mafA-3lkeA:
undetectable		 5mafA-3lkeA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		5 / 12 VAL A  89
MET A 119
ALA A 106
LEU A  32
VAL A   6
 None
 1.29A 5tudD-3lkeA:
undetectable		 5tudD-3lkeA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3lke ENOYL-COA HYDRATASE
(Bacillus
halodurans) 		3 / 3 LEU A 182
ASP A 124
ILE A  97
 None
 0.59A 6dh0B-3lkeA:
undetectable		 6dh0B-3lkeA:
17.37