SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  88
VAL A  82
TRP A 122
 None
 0.91A 1av2C-3lkuA:
undetectable
1av2D-3lkuA:
undetectable		 1av2C-3lkuA:
6.47
1av2D-3lkuA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  63
GLY A  59
THR A  35
PHE A  20
 None
 1.20A 1icuC-3lkuA:
undetectable
1icuD-3lkuA:
undetectable		 1icuC-3lkuA:
21.12
1icuD-3lkuA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  63
GLY A  59
THR A  35
PHE A  20
 None
 1.23A 1icvA-3lkuA:
undetectable
1icvB-3lkuA:
undetectable		 1icvA-3lkuA:
21.12
1icvB-3lkuA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 219
VAL A 195
LEU A 215
LEU A 250
ILE A 236
 None
 1.34A 1kqwA-3lkuA:
undetectable		 1kqwA-3lkuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  88
VAL A  82
TRP A 122
 None
 0.93A 1w5uC-3lkuA:
undetectable
1w5uD-3lkuA:
undetectable		 1w5uC-3lkuA:
6.47
1w5uD-3lkuA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  82
TRP A 122
VAL A  88
 None
 0.85A 2izqA-3lkuA:
undetectable
2izqB-3lkuA:
undetectable		 2izqA-3lkuA:
6.47
2izqB-3lkuA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  59
GLY A  72
LEU A  79
THR A  35
LEU A  36
 None
 1.04A 3p2kB-3lkuA:
undetectable		 3p2kB-3lkuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 160
ASP A 163
ASP A 170
VAL A 169
ASN A 203
 None
 1.25A 3v8vB-3lkuA:
undetectable		 3v8vB-3lkuA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		5 / 11 MET A 165
GLY A 160
ASP A 170
VAL A 169
ASN A 203
 None
 1.26A 3v8vB-3lkuA:
undetectable		 3v8vB-3lkuA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  72
ILE A  76
LEU A  64
LEU A  61
 None
 0.72A 4mwzB-3lkuA:
undetectable		 4mwzB-3lkuA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 120
PHE A 126
TYR A  83
 None
 0.78A 4u15A-3lkuA:
2.5		 4u15A-3lkuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 245
GLN A 249
VAL A 237
PHE A 239
LYS A 211
 None
 1.27A 5i8fA-3lkuA:
undetectable		 5i8fA-3lkuA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3lku UPF0363 PROTEIN
YOR164C
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 226
LYS A 228
LEU A 215
GLU A 216
 None
 1.39A 5js1A-3lkuA:
undetectable		 5js1A-3lkuA:
15.43