SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		4 / 6 GLU A  22
ILE A 189
TYR A 200
GLY A 186
 None
 0.97A 1maaB-3lkwA:
undetectable
1maaD-3lkwA:
undetectable		 1maaB-3lkwA:
18.21
1maaD-3lkwA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		4 / 8 TYR A 200
GLY A 183
THR A 184
ALA A 185
 None
 0.62A 2a1hA-3lkwA:
undetectable
2a1hB-3lkwA:
undetectable		 2a1hA-3lkwA:
21.53
2a1hB-3lkwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		4 / 8 TYR A 200
GLY A 183
THR A 184
ALA A 185
 None
 0.62A 2a1hA-3lkwA:
undetectable
2a1hB-3lkwA:
undetectable		 2a1hA-3lkwA:
21.53
2a1hB-3lkwA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		5 / 9 PHE A  96
THR A  98
VAL A 102
ALA A 106
LEU A 108
 None
 0.74A 2m9qA-3lkwA:
6.5		 2m9qA-3lkwA:
63.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		4 / 4 SER A  69
PRO A  70
PHE A  91
PRO A  68
 None
 1.45A 3bjwA-3lkwA:
0.0		 3bjwA-3lkwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_2
(PHOSPHOLIPASE A2)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		4 / 4 SER A  69
PRO A  70
PHE A  91
PRO A  68
 None
 1.47A 3bjwG-3lkwA:
0.0		 3bjwG-3lkwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_1
(PHOSPHOLIPASE A2)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		4 / 4 SER A  69
PRO A  70
PHE A  91
PRO A  68
 None
 1.46A 3bjwD-3lkwA:
0.0		 3bjwD-3lkwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		4 / 7 LEU A 126
ILE A 215
ILE A 176
VAL A 147
 None
 0.70A 3r9vA-3lkwA:
undetectable
3r9vB-3lkwA:
undetectable		 3r9vA-3lkwA:
21.92
3r9vB-3lkwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		5 / 12 HIS A 101
VAL A 122
ASP A 125
GLY A 183
ALA A 185
 GOL  A 303 (-3.7A)
None
GOL  A 303 ( 4.7A)
None
None
 0.34A 3sudD-3lkwA:
4.9		 3sudD-3lkwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		5 / 12 HIS A 101
VAL A 122
ASP A 125
GLY A 183
ALA A 185
 GOL  A 303 (-3.7A)
None
GOL  A 303 ( 4.7A)
None
None
 0.34A 3sugA-3lkwA:
12.8		 3sugA-3lkwA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		5 / 12 ILE A 196
THR A 103
VAL A 102
LEU A 199
LEU A   9
 None
 1.27A 4qynA-3lkwA:
undetectable		 4qynA-3lkwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		3 / 3 VAL A 197
SER A 138
TRP A 139
 None
 0.87A 5jwaA-3lkwA:
undetectable		 5jwaA-3lkwA:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		4 / 5 HIS A 101
TYR A 200
GLY A 201
TYR A 211
 GOL  A 303 (-3.7A)
None
None
GOL  A 303 (-4.8A)
 0.37A 5yodH-3lkwA:
24.5		 5yodH-3lkwA:
43.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3
(Dengue
virus) 		5 / 12 HIS A 101
VAL A 122
ASP A 125
GLY A 183
VAL A 212
 GOL  A 303 (-3.7A)
None
GOL  A 303 ( 4.7A)
None
None
 0.77A 6c2mC-3lkwA:
5.9		 6c2mC-3lkwA:
18.53